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The probability that a configuration of a physical system reacts, or transitions from one metastable state to another, is quantified by the committor function. This function contains richly detailed mechanistic information about transition…

Statistical Mechanics · Physics 2024-08-13 Andrew R. Mitchell , Grant M. Rotskoff

As an optimal one-dimensional reaction coordinate, the committor function not only describes the probability of a trajectory initiated at a phase space point first reaching the product state before reaching the reactant state, but also…

Chemical Physics · Physics 2024-10-08 Xiaojun Ji , Ru Wang , Hao Wang , Wenjian Liu

Computing long-timescale kinetics of biomolecular processes remains a major challenge for atomistic simulations. A way out is to exploit local kinetic information to construct the global stationary flux across the reaction space. The…

Chemical Physics · Physics 2026-05-19 Ru Wang , Xiaojun Ji , Hao Wang , Wenjian Liu

Efficient task scheduling is paramount in the Linux kernel, where the Completely Fair Scheduler (CFS) meticulously manages CPU resources to balance high utilization with interactive responsiveness. This research pioneers the use of deep…

Machine Learning · Computer Science 2025-05-22 Sampanna Yashwant Kahu

Atomistic simulations are widely used to investigate reactive processes but are often limited by the rare event problem due to kinetic bottlenecks. We recently introduced an enhanced sampling approach based on the committor function,…

Computational Physics · Physics 2026-03-02 Enrico Trizio , Giorgia Rossi , Michele Parrinello

The committor function is a central object of study in understanding transitions between metastable states in complex systems. However, computing the committor function for realistic systems at low temperatures is a challenging task, due to…

Computational Physics · Physics 2019-09-04 Qianxiao Li , Bo Lin , Weiqing Ren

Improvement of statistical learning models in order to increase efficiency in solving classification or regression problems is still a goal pursued by the scientific community. In this way, the support vector machine model is one of the…

Machine Learning · Statistics 2019-11-22 Anderson Ara , Mateus Maia , Samuel Macêdo , Francisco Louzada

Among various soft computing approaches for time series forecasting, Fuzzy Cognitive Maps (FCM) have shown remarkable results as a tool to model and analyze the dynamics of complex systems. FCM have similarities to recurrent neural networks…

Artificial Intelligence · Computer Science 2022-01-11 Omid Orang , Petrônio Cândido de Lima e Silva , Frederico Gadelha Guimarães

In this note we propose a method based on artificial neural network to study the transition between states governed by stochastic processes. In particular, we aim for numerical schemes for the committor function, the central object of…

Machine Learning · Computer Science 2018-03-01 Yuehaw Khoo , Jianfeng Lu , Lexing Ying

Kernels are often developed and used as implicit mapping functions that show impressive predictive power due to their high-dimensional feature space representations. In this study, we gradually construct a series of simple feature maps that…

Machine Learning · Computer Science 2020-07-20 Gurhan Ceylan , S. Ilker Birbil

The committor function is a central object for quantifying the transitions between metastable states of dynamical systems. Recently, a number of computational methods based on deep neural networks have been developed for computing the…

Computational Physics · Physics 2024-04-10 Bo Lin , Weiqing Ren

Motivation: In a predictive modeling setting, if sufficient details of the system behavior are known, one can build and use a simulation for making predictions. When sufficient system details are not known, one typically turns to machine…

Machine Learning · Statistics 2019-08-14 Timo M. Deist , Andrew Patti , Zhaoqi Wang , David Krane , Taylor Sorenson , David Craft

Classical machine learning has succeeded in the prediction of both classical and quantum phases of matter. Notably, kernel methods stand out for their ability to provide interpretable results, relating the learning process with the physical…

Quantum Physics · Physics 2022-05-05 Teresa Sancho-Lorente , Juan Román-Roche , David Zueco

The committor functions are central to investigating rare but important events in molecular simulations. It is known that computing the committor function suffers from the curse of dimensionality. Recently, using neural networks to estimate…

Machine Learning · Statistics 2025-01-28 Yueyang Wang , Kejun Tang , Xili Wang , Xiaoliang Wan , Weiqing Ren , Chao Yang

Predictive inference is a fundamental task in statistics, traditionally addressed using parametric assumptions about the data distribution and detailed analyses of how models learn from data. In recent years, conformal prediction has…

Methodology · Statistics 2026-03-26 Matteo Sesia , Stefano Favaro

A central object in the computational studies of rare events is the committor function. Though costly to compute, the committor function encodes complete mechanistic information of the processes involving rare events, including reaction…

Statistical Mechanics · Physics 2022-11-23 Muhammad R. Hasyim , Clay H. Batton , Kranthi K. Mandadapu

Approximations based on random Fourier features have recently emerged as an efficient and formally consistent methodology to design large-scale kernel machines. By expressing the kernel as a Fourier expansion, features are generated based…

Computer Vision and Pattern Recognition · Computer Science 2012-03-08 Eduard Gabriel Băzăvan , Fuxin Li , Cristian Sminchisescu

We use a support vector regressor based on a projected quantum kernel method to predict the density structure of 1D fermionic systems of interest in quantum chemistry and quantum matter. The kernel is built on with the observables of a…

Quantum Physics · Physics 2025-09-01 Francesco Perciavalle , Francesco Plastina , Michele Pisarra , Nicola Lo Gullo

Quantum computing can empower machine learning models by enabling kernel machines to leverage quantum kernels for representing similarity measures between data. Quantum kernels are able to capture relationships in the data that are not…

We derive a Fast Multipole Method (FMM) where a low-rank approximation of the kernel is obtained using the Empirical Interpolation Method (EIM). Contrary to classical interpolation-based FMM, where the interpolation points and basis are…

Numerical Analysis · Mathematics 2015-08-25 Fabien Casenave
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