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This short paper presents an abstract, tunable model of genomic structural change within the cell lifecycle and explores its use with simulated evolution. A well-known Boolean model of genetic regulatory networks is extended to include…

Computational Engineering, Finance, and Science · Computer Science 2012-01-18 Larry Bull

Phylogenetic networks provide a means of describing the evolutionary history of sets of species believed to have undergone hybridization or gene flow during their evolution. The mutation process for a set of such species can be modeled as a…

Populations and Evolution · Quantitative Biology 2022-11-23 Travis Barton , Elizabeth Gross , Colby Long , Joseph Rusinko

Stochastic models in which agents interact with their neighborhood according to a network topology are a powerful modeling framework to study the emergence of complex dynamic patterns in real-world systems. Stochastic simulations are often…

Social and Information Networks · Computer Science 2021-01-27 Gerrit Großmann , Luca Bortolussi , Verena Wolf

The computational models for geophysical flows are computationally very expensive to employ in multi-query tasks such as data assimilation, uncertainty quantification, and hence surrogate models sought to alleviate the computational burden…

Computational Physics · Physics 2022-01-10 Suraj Pawar , Omer San , Gary G. Yen

Realistic fine-grained multi-agent simulation of real-world complex systems is crucial for many downstream tasks such as reinforcement learning. Recent work has used generative models (GANs in particular) for providing high-fidelity…

Machine Learning · Computer Science 2022-02-25 Changyu Chen , Avinandan Bose , Shih-Fen Cheng , Arunesh Sinha

This paper studies the impact of the initial data gathering method on the subsequent learning of a dynamics model. Dynamics models approximate the true transition function of a given task, in order to perform policy search directly on the…

Machine Learning · Computer Science 2022-10-24 Elias Hanna , Alex Coninx , Stéphane Doncieux

The application of phylogenetic techniques to the documentation of cultural history can present a distorted picture due to horizontal transmission and blending. Moreover, the units of cultural transmission must be communicable concepts,…

Populations and Evolution · Quantitative Biology 2019-07-11 Liane Gabora , Stefan Leijnen , Tomas Veloz , Carl Lipo

The fundamental understanding of how cells physically interact with each other and their environment is key to understanding their organisation in living tissues. Over the past decades several computational methods have been developed to…

Quantitative Methods · Quantitative Biology 2026-01-22 Paul Van Liedekerke , Jiří Pešek , Kevin Alessandri , Dirk Drasdo

We propose a reinforcement-learning algorithm to tackle the challenge of reconstructing phylogenetic trees. The search for the tree that best describes the data is algorithmically challenging, thus all current algorithms for phylogeny…

Populations and Evolution · Quantitative Biology 2023-03-14 Dana Azouri , Oz Granit , Michael Alburquerque , Yishay Mansour , Tal Pupko , Itay Mayrose

Phylogenetic comparative methods are well established tools for using inter-species variation to analyse phenotypic evolution and adaptation. They are generally hampered, however, by predominantly univariate approaches and failure to…

Populations and Evolution · Quantitative Biology 2024-12-13 Krzysztof Bartoszek

In statistical genetics an important task involves building predictive models for the genotype-phenotype relationships and thus attribute a proportion of the total phenotypic variance to the variation in genotypes. Numerous models have been…

Applications · Statistics 2016-03-30 Deniz Akdemir , Jean-Luc Jannink

Due to decelerating gains in single-core CPU performance, computationally expensive simulations are increasingly executed on highly parallel hardware platforms. Agent-based simulations, where simulated entities act with a certain degree of…

Multiagent Systems · Computer Science 2018-07-04 Jiajian Xiao , Philipp Andelfinger , David Eckhoff , Wentong Cai , Alois Knoll

Foraging for resources is a ubiquitous activity conducted by living organisms in a shared environment to maintain their homeostasis. Modelling multi-agent foraging in-silico allows us to study both individual and collective emergent…

Multiagent Systems · Computer Science 2025-10-16 Siddharth Chaturvedi , Ahmed El-Gazzar , Marcel van Gerven

In single-cell research, tracing and analyzing high-throughput single-cell differentiation trajectories is crucial for understanding biological processes. Key to this is the robust modeling of hierarchical structures that govern cellular…

Machine Learning · Computer Science 2026-05-19 Zelin Zang , WenZhe Li , Yongjie Xu , Chang Yu , Changxi Chi , Jingbo Zhou , Zhen Lei , Stan Z. Li

Accurate predictions and representations of plant growth patterns in simulated and controlled environments are important for addressing various challenges in plant phenomics research. This review explores various works on state-of-the-art…

Quantitative Methods · Quantitative Biology 2025-07-17 Mohamed Debbagh , Shangpeng Sun , Mark Lefsrud

The fusion of the multi-agent paradigm with evolutionary computation yielded promising results in many optimization problems. Evolutionary multi-agent system (EMAS) are more similar to biological evolution than classical evolutionary…

Multiagent Systems · Computer Science 2015-08-13 D. Krzywicki , W. Turek , A. Byrski , M. Kisiel-Dorohinicki

Numerical models based on physics represent the state-of-the-art in earth system modeling and comprise our best tools for generating insights and predictions. Despite rapid growth in computational power, the perceived need for higher model…

Machine Learning · Computer Science 2022-01-10 Kate Duffy , Thomas Vandal , Weile Wang , Ramakrishna Nemani , Auroop R. Ganguly

We present a model for evolving agents using both genetic and cultural inheritance mechanisms. Within each agent our model maintains two distinct information stores we call the genome and the memome. Processes of adaptation are modeled as…

Neural and Evolutionary Computing · Computer Science 2016-04-26 Chris Marriott , Jobran Chebib

Modern biological techniques enable very dense genetic sampling of unfolding evolutionary histories, and thus frequently sample some genotypes multiple times. This motivates strategies to incorporate genotype abundance information in…

Populations and Evolution · Quantitative Biology 2018-04-09 William S. DeWitt , Luka Mesin , Gabriel D. Victora , Vladimir N. Minin , Frederick A. Matsen

Phylogenetic inference, the task of reconstructing how related sequences evolved from common ancestors, is a central objective in evolutionary genomics. The current state-of-the-art methods exploit probabilistic models of sequence evolution…

Populations and Evolution · Quantitative Biology 2026-02-19 Luc Blassel , Noémie Sauvage , Pierre Barrat-Charlaix , Bastien Boussau , Nicolas Lartillot , Laurent Jacob
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