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Despite decades of advancements in automated ligand screening, large-scale drug discovery remains resource-intensive and requires post-processing hit selection, a step where chemists manually select a few promising molecules based on their…

Machine Learning · Computer Science 2025-03-24 Tai Dang , Long-Hung Pham , Sang T. Truong , Ari Glenn , Wendy Nguyen , Edward A. Pham , Jeffrey S. Glenn , Sanmi Koyejo , Thang Luong

Realizing high-throughput aberration-corrected Scanning Transmission Electron Microscopy (STEM) exploration of atomic structures requires rapid tuning of multipole probe correctors while compensating for the inevitable drift of the optical…

Machine Learning · Computer Science 2026-01-28 Utkarsh Pratiush , Austin Houston , Richard Liu , Gerd Duscher , Sergei Kalinin

In this study, a machine learning-based technique is developed to reduce the computational cost required to explore large design spaces of substitutional alloys. The first advancement is based on a neural network approach to predict the…

Computational Physics · Physics 2020-04-03 Alhassan S. Yasin , Terence D. Musho

We propose an efficient computational methodology for predicting the synthesizability of high entropy oxides (HEOs) in a large space of possible candidate compounds. HEOs are a growing field with an enormous potential chemical composition…

Materials Science · Physics 2026-03-03 Oliver A. Dicks , Solveig S. Aamlid , Alannah M. Hallas , Joerg Rottler

Advancements in materials play a crucial role in technological progress. However, the process of discovering and developing materials with desired properties is often impeded by substantial experimental costs, extensive resource…

Machine Learning · Computer Science 2023-11-17 Ahmed Shoyeb Raihan , Hamed Khosravi , Srinjoy Das , Imtiaz Ahmed

The discovery of therapeutic molecules is fundamentally a multi-objective optimization problem. One formulation of the problem is to identify molecules that simultaneously exhibit strong binding affinity for a target protein, minimal…

Quantitative Methods · Quantitative Biology 2023-10-17 Jenna C. Fromer , David E. Graff , Connor W. Coley

Active learning strategies for 3D object detection in autonomous driving datasets may help to address challenges of data imbalance, redundancy, and high-dimensional data. We demonstrate the effectiveness of entropy querying to select…

Computer Vision and Pattern Recognition · Computer Science 2024-01-31 Ross Greer , Bjørk Antoniussen , Mathias V. Andersen , Andreas Møgelmose , Mohan M. Trivedi

In the dynamic and rapidly advancing battery field, alloy anode materials are a focal point due to their superior electrochemical performance. Traditional screening methods are inefficient and time-consuming. Our research introduces a…

Materials Science · Physics 2024-09-17 Xingyue Shi , Linming Zhou , Yuhui Huang , Yongjun Wu , Zijian Hong

High entropy alloys (HEAs) represent a novel frontier in metallurgical advancements, offering exceptional mechanical properties owing to their unique multicomponent nature. This study explores a novel strategy utilising commodity powders -…

Materials Science · Physics 2024-07-04 A. Meza , A. Barbosa , E. Tabares , J. M. Torralba

The current bulk materials discovery cycle has several inefficiencies from initial computational predictions through fabrication and analyses. Materials are generally evaluated in a singular fashion, relying largely on human-driven…

Materials Science · Physics 2021-02-12 Olivia F. Dippo , Kevin R. Kaufmann , Kenneth S. Vecchio

High throughput screening of compounds (chemicals) is an essential part of drug discovery [7], involving thousands to millions of compounds, with the purpose of identifying candidate hits. Most statistical tools, including the industry…

Machine Learning · Statistics 2017-09-29 Ivo D. Shterev , David B. Dunson , Cliburn Chan , Gregory D. Sempowski

High-entropy alloys (HEAs) are metallic materials with solid solutions stabilized by high mixing entropy. Some exhibit excellent strength, often accompanied by additional properties such as magnetic, invar, corrosion, or cryogenic response.…

Materials Science · Physics 2024-09-26 Anurag Bajpai , Ziyuan Rao , Abhinav Dixit , Krishanu Biswas , Dierk Raabe

Efficient exploration of vast compositional and processing spaces is essential for accelerated materials discovery. Bayesian optimization (BO) provides a principled strategy for identifying optimal materials with minimal experiments, yet…

Multi-fidelity Bayesian Optimization (MFBO) is a promising framework to speed up materials and molecular discovery as sources of information of different accuracies are at hand at increasing cost. Despite its potential use in chemical…

Machine learning (ML) models utilizing structure-based features provide an efficient means for accurate property predictions across diverse chemical spaces. However, obtaining equilibrium crystal structures typically requires expensive…

Materials Science · Physics 2021-04-22 Yunxing Zuo , Mingde Qin , Chi Chen , Weike Ye , Xiangguo Li , Jian Luo , Shyue Ping Ong

We present an active tactile exploration framework for joint object recognition and 6D pose estimation. The proposed method integrates wrist force/torque sensing, GelSight tactile sensing, and free-space constraints within a Bayesian…

Controlling the properties of organic/inorganic materials requires detailed knowledge of their molecular adsorption geometries. This is often unattainable, even with current state-of-the-art tools. Visualizing the structure of complex…

We propose a novel hardware and software co-exploration framework for efficient neural architecture search (NAS). Different from existing hardware-aware NAS which assumes a fixed hardware design and explores the neural architecture search…

Machine Learning · Computer Science 2020-01-14 Weiwen Jiang , Lei Yang , Edwin Sha , Qingfeng Zhuge , Shouzhen Gu , Sakyasingha Dasgupta , Yiyu Shi , Jingtong Hu

The next generation of advanced materials is tending toward increasingly complex compositions. Synthesizing precise composition is time-consuming and becomes exponentially demanding with increasing compositional complexity. An experienced…

Materials Science · Physics 2024-03-12 Nathan Johnson , Aashwin Ananda Mishra , Apurva Mehta

Incremental few-shot learning is highly expected for practical robotics applications. On one hand, robot is desired to learn new tasks quickly and flexibly using only few annotated training samples; on the other hand, such new additional…

Computer Vision and Pattern Recognition · Computer Science 2022-03-24 Yiting Li , Haiyue Zhu , Sichao Tian , Fan Feng , Jun Ma , Chek Sing Teo , Cheng Xiang , Prahlad Vadakkepat , Tong Heng Lee