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We present a numerical analysis of the rheology of a suspension of red blood cells (RBCs) in a wall-bounded shear flow. The flow is assumed as almost inertialess. The suspension of RBCs, modeled as biconcave capsules whose membrane follows…

Fluid Dynamics · Physics 2019-07-24 Naoki Takeishi , Marco E. Rosti , Yohsuke Imai , Shigeo Wada , Luca Brandt

Red blood cells (RBCs) from the cord blood of newborn infants have distinctive functions for fetal and infant development. To systematically investigate the biophysical characteristics of individual cord RBCs in newborn infants, a…

Blood viscosity decreases with shear stress, a property essential for an efficient perfusion of the vascular tree. Shear-thinning is intimately related to the dynamics and mutual interactions of red blood cells (RBCs), the major…

The functionality and viability of stored human red blood cells (RBCs) is an important clinical issue in transfusion. To systematically investigate changes in stored whole blood, the hematological properties of individual RBCs were…

Medical Physics · Physics 2015-06-30 HyunJoo Park , Misook Ji , SangYun Lee , Kyoohyun Kim , Yong-Hak Sohn , Seongsoo Jang , YongKeun Park

We use mesoscale numerical simulations to investigate the unsteady dynamics of a single red blood cell (RBC) subjected to an external mechanical load. We carry out a detailed comparison between the {\it loading} (L) dynamics, following the…

Soft Condensed Matter · Physics 2021-06-01 Fabio Guglietta , Marek Behr , Giacomo Falcucci , Mauro Sbragaglia

We present a rigorous procedure to derive coarse-grained red blood cell (RBC) models, which lead to accurate mechanical properties of realistic RBCs. Based on a semi-analytic theory linear and non-linear elastic properties of the RBC…

Cell Behavior · Quantitative Biology 2009-05-04 Dmitry A. Fedosov , Bruce Caswell , George E. Karniadakis

We show, via three-dimensional immersed-boundary-finite-element-lattice-Boltzmann simulations, that deformability-based red blood cell (RBC) separation in deterministic lateral displacement (DLD) devices is possible. This is due to the…

Soft Condensed Matter · Physics 2016-03-15 Timm Krüger , David Holmes , Peter V. Coveney

We present a numerical analysis of the rheology of a suspension of red blood cells (RBCs) for different volume fractions in a wall-bounded, effectively inertialess, small amplitude oscillatory shear (SAOS) flow for a wide range of applied…

Fluid Dynamics · Physics 2024-04-08 Naoki Takeishi , Marco Edoardo Rosti , Naoto Yokoyama , Luca Brandt

The stress-free state (SFS) of red blood cells (RBCs) is a fundamental reference configuration for the calibration of computational models, yet it remains unknown. Current experimental methods cannot measure the SFS of cells without…

Computational Engineering, Finance, and Science · Computer Science 2023-04-04 Lucas Amoudruz , Athena Economides , Georgios Arampatzis , Petros Koumoutsakos

Driven or active suspensions can display fascinating collective behavior, where coherent motions or structures arise on a scale much larger than that of the constituent particles. Here, we report experiments and numerical simulations…

Red blood cells (RBCs) are an essential component of blood. A method to include the particulate nature of blood is introduced here with the goal of studying circulation in large-scale realistic vessels. The method uses a combination of the…

Medical Physics · Physics 2011-07-26 Simone Melchionna

Red Blood Cells (RBCs) are the simplest cell types with complex dynamical and viscoelastic phenomenology. While the mechanical rigidity and the flickering noise of RBCs have been extensively investigated, an accurate determination of the…

Biological Physics · Physics 2023-08-25 M. Gironella-Torrent , G. Bergamaschi , R. Sorkin , G. Wuite , F. Ritort

The fluid dynamics video presented here outlines recent advances in the simulation of multiphase cellular blood flow through the direct numerical simulations of deformable red blood cells (RBCs) demonstrated through several numerical…

Fluid Dynamics · Physics 2010-10-18 Daniel A. Reasor , Jonathan R. Clausen , Brian M. Yun , Cyrus K. Aidun

We present rheology experiments on dilute solutions of vesicles and red blood cells (RBC). Varying the viscosity ratio $\lambda$ between internal and external fluids, the microscopic dynamics of suspended objects can be qualitatively…

Soft Condensed Matter · Physics 2007-07-31 Victoria Vitkova , Maud-Alix Mader , Chaouqi Misbah , Thomas Podgorski

Red blood cells flowing through capillaries assume a wide variety of different shapes owing to their high deformability. Predicting the realized shapes is a complex field as they are determined by the intricate interplay between the flow…

Biological Physics · Physics 2017-11-21 Achim Guckenberger , Alexander Kihm , Thomas John , Christian Wagner , Stephan Gekle

The red blood cell (RBC) membrane is composed of a lipid bilayer and a cytoskeleton interconnected by protein junction complexes, allowing for potential sliding between the lipid bilayer and the cytoskeleton. Despite this biological…

Fluid Dynamics · Physics 2024-01-23 V. Puthumana , P. G. Chen , M. Leonetti , R. Lasserre , M. Jaeger

We present a numerical analysis of the lateral movement and equilibrium radial positions of red blood cells (RBCs) with major diameter of 8 $\mu$m under a Newtonian fluid in a circular channel with 50-$\mu$m diameter. Each RBC, modelled as…

Motivated by the complex rheological behaviors observed in small/micro scale blood vessels, such as the Fahraeus effect, plasma-skimming, shear-thinning, etc., we develop a non-linear suspension model for blood. The viscosity is assumed to…

Fluid Dynamics · Physics 2018-12-26 Wei-Tao Wu , Nadine Aubry , James F. Antaki , Mehrdad Massoudi

Red blood cell (RBC) deformation is the consequence of several diseases, including sickle cell anemia, which causes recurring episodes of pain and severe pronounced anemia. Monitoring patients with these diseases involves the observation of…

Computer Vision and Pattern Recognition · Computer Science 2026-01-27 Wilkie Delgado-Font , Miriela Escobedo-Nicot , Manuel González-Hidalgo , Silena Herold-Garcia , Antoni Jaume-i-Capó , Arnau Mir

It is important to understand the dynamics of red blood cells (RBCs) in blood flow. This requires the formulation of coarse-grained RBC models that reproduce the hydrodynamic properties of blood accurately. One of the models that…

Soft Condensed Matter · Physics 2024-10-15 Tetsuya Yamamoto , Hiroshi Watanabe
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