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Reinforcement learning (RL) can align language models with non-differentiable reward signals, such as human preferences. However, a major challenge arises from the sparsity of these reward signals - typically, there is only a single reward…

Computation and Language · Computer Science 2024-02-20 Meng Cao , Lei Shu , Lei Yu , Yun Zhu , Nevan Wichers , Yinxiao Liu , Lei Meng

We present ReCAD, a reinforcement learning (RL) framework that bootstraps pretrained large models (PLMs) to generate precise parametric computer-aided design (CAD) models from multimodal inputs by leveraging their inherent generative…

Computer Vision and Pattern Recognition · Computer Science 2025-12-09 Jiahao Li , Yusheng Luo , Yunzhong Lou , Xiangdong Zhou

Designing de-novo molecules with desired property profiles requires efficient exploration of the vast chemical space ranging from $10^{23}$ to $10^{60}$ possible synthesizable candidates. While various deep generative models have been…

Machine Learning · Computer Science 2025-08-25 Kamran Chitsaz , Roshan Balaji , Quentin Fournier , Nirav Pravinbhai Bhatt , Sarath Chandar

Reinforcement fine-tuning played an instrumental role in enhancing the instruction-following and reasoning abilities of large language models. In this work, we employ reinforcement fine-tuning for materials design, in which discriminative…

Materials Science · Physics 2026-01-19 Zhendong Cao , Lei Wang

Protein generative models have shown remarkable promise in protein design, yet their success rates remain constrained by reliance on curated sequence-structure datasets and by misalignment between supervised objectives and real design…

Machine Learning · Computer Science 2026-03-03 Ziwen Wang , Jiajun Fan , Ruihan Guo , Thao Nguyen , Heng Ji , Ge Liu

Production machine translation relies overwhelmingly on encoder-decoder Seq2Seq models, yet reinforcement learning approaches to MT fine-tuning have largely targeted decoder-only LLMs at $\geq$7B parameters, with limited systematic study of…

Computation and Language · Computer Science 2026-05-18 Ernesto Garcia-Estrada , Carlos Escolano , José A. R. Fonallosa

Radiology report generation requires advanced medical image analysis, effective temporal reasoning, and accurate text generation. Although recent innovations, particularly multimodal large language models, have shown improved performance,…

Computation and Language · Computer Science 2025-11-11 Kai Zhang , Christopher Malon , Lichao Sun , Martin Renqiang Min

Generating keyphrases that summarize the main points of a document is a fundamental task in natural language processing. Although existing generative models are capable of predicting multiple keyphrases for an input document as well as…

Computation and Language · Computer Science 2019-06-11 Hou Pong Chan , Wang Chen , Lu Wang , Irwin King

Machine Learning-guided solutions for protein learning tasks have made significant headway in recent years. However, success in scientific discovery tasks is limited by the accessibility of well-defined and labeled in-domain data. To tackle…

Machine Learning · Computer Science 2023-01-06 Ria Vinod , Pin-Yu Chen , Payel Das

Reinforcement learning (RL) algorithms typically deal with maximizing the expected cumulative return (discounted or undiscounted, finite or infinite horizon). However, several crucial applications in the real world, such as drug discovery,…

The advent of large pre-trained language models in the domain of Code Synthesis has shown remarkable performance on various benchmarks, treating the problem of Code Generation in a fashion similar to Natural Language Generation, trained…

Machine Learning · Computer Science 2023-10-23 Philip John Gorinski , Matthieu Zimmer , Gerasimos Lampouras , Derrick Goh Xin Deik , Ignacio Iacobacci

E-commerce platforms and payment solution providers face increasingly sophisticated fraud schemes, ranging from identity theft and account takeovers to complex money laundering operations that exploit the speed and anonymity of digital…

Artificial Intelligence · Computer Science 2026-01-12 Cooper Lin , Yanting Zhang , Maohao Ran , Wei Xue , Hongwei Fan , Yibo Xu , Zhenglin Wan , Sirui Han , Yike Guo , Jun Song

In recent years, machine learning technologies have gained immense popularity and are being used in a wide range of domains. However, due to the complexity associated with machine learning algorithms, it is a challenge to make it…

Software Engineering · Computer Science 2024-10-15 Natalie Sinani , Sahil Salma , Paul Boutot , Sadaf Mustafiz

Generative models have made significant progress in synthesizing visual content, including images, videos, and 3D/4D structures. However, they are typically trained with surrogate objectives such as likelihood or reconstruction loss, which…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Yuanzhi Liang , Yijie Fang , Ke Hao , Rui Li , Ziqi Ni , Ruijie Su , Chi Zhang

Reinforcement learning (RL) is emerging as a powerful paradigm for enabling large language models (LLMs) to perform complex reasoning tasks. Recent advances indicate that integrating RL with retrieval-augmented generation (RAG) allows LLMs…

Computation and Language · Computer Science 2025-08-13 Wentao Jiang , Xiang Feng , Zengmao Wang , Yong Luo , Pingbo Xu , Zhe Chen , Bo Du , Jing Zhang

Molecular language modeling is an effective approach to generating novel chemical structures. However, these models do not \emph{a priori} encode certain preferences a chemist may desire. We investigate the use of fine-tuning using Direct…

Machine Learning · Statistics 2023-10-20 Ryan Park , Ryan Theisen , Navriti Sahni , Marcel Patek , Anna Cichońska , Rayees Rahman

Test-time scaling methods have seen a rapid increase in popularity for its computational efficiency and parameter-independent training to improve reasoning performance on Large Language Models. One such method is called budget forcing, a…

Artificial Intelligence · Computer Science 2025-10-27 Ravindra Aribowo Tarunokusumo , Rafael Fernandes Cunha

Steering language generation towards objectives or away from undesired content has been a long-standing goal in utilizing language models (LM). Recent work has demonstrated reinforcement learning and weighted decoding as effective…

Computation and Language · Computer Science 2022-12-22 Minbeom Kim , Hwanhee Lee , Kang Min Yoo , Joonsuk Park , Hwaran Lee , Kyomin Jung

In the scope of drug discovery, the molecular design aims to identify novel compounds from the chemical space where the potential drug-like molecules are estimated to be in the order of 10^60 - 10^100. Since this search task is…

Machine Learning · Computer Science 2022-10-25 Wenlu Wang , Ye Wang , Honggang Zhao , Simone Sciabola

Speech large language models (LLMs) have driven significant progress in end-to-end speech understanding and recognition, yet they continue to struggle with accurately recognizing rare words and domain-specific terminology. This paper…

Audio and Speech Processing · Electrical Eng. & Systems 2026-01-21 Bo Ren , Ruchao Fan , Yelong Shen , Weizhu Chen , Jinyu Li