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Systematic identification of protein function is a key problem in current biology. Most traditional methods fail to identify functionally equivalent proteins if they lack similar sequences, structural data or extensive manual annotations.…

Genomics · Quantitative Biology 2016-03-08 Dan Ofer

Large language models (LLMs) are increasingly being deployed across disciplines due to their advanced reasoning and problem solving capabilities. To measure their effectiveness, various benchmarks have been developed that measure aspects of…

Large Language Models (LLMs) are the cornerstone in automating Requirements Engineering (RE) tasks, underpinning recent advancements in the field. Their pre-trained comprehension of natural language is pivotal for effectively tailoring them…

Software Engineering · Computer Science 2024-05-16 Andreas Vogelsang , Jannik Fischbach

Large language models (LLMs) are a class of artificial intelligence models based on deep learning, which have great performance in various tasks, especially in natural language processing (NLP). Large language models typically consist of…

Quantitative Methods · Quantitative Biology 2025-02-04 Jiajia Liu , Mengyuan Yang , Yankai Yu , Haixia Xu , Tiangang Wang , Kang Li , Xiaobo Zhou

We are witnessing a bloom of AI-powered software driven by Large Language Models (LLMs). Although the applications of these LLMs are impressive and seemingly countless, their unreliability hinders adoption. In fact, the tendency of LLMs to…

Software Engineering · Computer Science 2025-10-30 Vincenzo Scotti , Jan Keim , Tobias Hey , Andreas Metzger , Anne Koziolek , Raffaela Mirandola

3D Multimodal Large Language Models (MLLMs) have recently made substantial advancements. However, their potential remains untapped, primarily due to the limited quantity and suboptimal quality of 3D datasets. Current approaches attempt to…

Computer Vision and Pattern Recognition · Computer Science 2025-03-14 Zilu Guo , Hongbin Lin , Zhihao Yuan , Chaoda Zheng , Pengshuo Qiu , Dongzhi Jiang , Renrui Zhang , Chun-Mei Feng , Zhen Li

Deep learning has deeply influenced protein science, enabling breakthroughs in predicting protein properties, higher-order structures, and molecular interactions. This paper introduces DeepProtein, a comprehensive and user-friendly deep…

Machine Learning · Computer Science 2025-06-17 Jiaqing Xie , Tianfan Fu

Large Language Models (LLMs) have shown significant potential for ontology engineering. However, it is still unclear to what extent they are applicable to the task of domain-specific ontology generation. In this study, we explore the…

A Large Language Model (LLM) represents a cutting-edge artificial intelligence model that generates coherent content, including grammatically precise sentences, human-like paragraphs, and syntactically accurate code snippets. LLMs can play…

Software Engineering · Computer Science 2023-12-11 Robson Santos , Italo Santos , Cleyton Magalhaes , Ronnie de Souza Santos

For protein sequence datasets, unlabeled data has greatly outpaced labeled data due to the high cost of wet-lab characterization. Recent deep-learning approaches to protein prediction have shown that pre-training on unlabeled data can yield…

Machine Learning · Computer Science 2020-12-02 Pascal Sturmfels , Jesse Vig , Ali Madani , Nazneen Fatema Rajani

Recent years have witnessed a surge in the development of protein foundation models, significantly improving performance in protein prediction and generative tasks ranging from 3D structure prediction and protein design to conformational…

Quantitative Methods · Quantitative Biology 2024-10-08 Fei Ye , Zaixiang Zheng , Dongyu Xue , Yuning Shen , Lihao Wang , Yiming Ma , Yan Wang , Xinyou Wang , Xiangxin Zhou , Quanquan Gu

Language is essentially a complex, intricate system of human expressions governed by grammatical rules. It poses a significant challenge to develop capable AI algorithms for comprehending and grasping a language. As a major approach,…

The integration of large language models (LLMs) into automated algorithm design has shown promising potential. A prevalent approach embeds LLMs within search routines to iteratively generate and refine candidate algorithms. However, most…

Machine Learning · Computer Science 2026-05-20 Fei Liu , Rui Zhang , Xi Lin , Zhichao Lu , Qingfu Zhang

Effective processing, interpretation, and management of sensor data have emerged as a critical component of cyber-physical systems. Traditionally, processing sensor data requires profound theoretical knowledge and proficiency in…

Artificial Intelligence · Computer Science 2025-04-01 Pengrui Quan , Xiaomin Ouyang , Jeya Vikranth Jeyakumar , Ziqi Wang , Yang Xing , Mani Srivastava

Training large language models (LLMs) from scratch requires significant computational resources, driving interest in developing smaller, domain-specific LLMs that maintain both efficiency and strong task performance. Medium-sized models…

Computation and Language · Computer Science 2026-03-02 Chaitali Bhattacharyya , Hyunsei Lee , Junyoung Lee , Shinhyoung Jang , Il hong Suh , Yeseong Kim

Large Language Models (LLMs) have demonstrated remarkable performance across various natural language tasks, marking significant strides towards general artificial intelligence. While general artificial intelligence is leveraged by…

Computation and Language · Computer Science 2023-10-31 Yizhe Yang , Huashan Sun , Jiawei Li , Runheng Liu , Yinghao Li , Yuhang Liu , Heyan Huang , Yang Gao

Recent progress in Large Language Models (LLMs) has substantially advanced the automation of software engineering (SE) tasks, enabling complex activities such as code generation and code summarization. However, the black-box nature of LLMs…

Software Engineering · Computer Science 2025-12-24 Antonio Vitale , Khai-Nguyen Nguyen , Denys Poshyvanyk , Rocco Oliveto , Simone Scalabrino , Antonio Mastropaolo

With the rapid advancement of generative artificial intelligence, large language models (LLMs) are increasingly adopted in industrial domains, offering new opportunities for Prognostics and Health Management (PHM). These models help address…

Artificial Intelligence · Computer Science 2025-08-05 Puyu Yang , Laifa Tao , Zijian Huang , Haifei Liu , Wenyan Cao , Hao Ji , Jianan Qiu , Qixuan Huang , Xuanyuan Su , Yuhang Xie , Jun Zhang , Shangyu Li , Chen Lu , Zhixuan Lian

Large Language Models (LLMs) have emerged as a transformative power in enhancing natural language comprehension, representing a significant stride toward artificial general intelligence. The application of LLMs extends beyond conventional…

Large language models (LLMs) have become important tools in solving biological problems, offering improvements in accuracy and adaptability over conventional methods. Several benchmarks have been proposed to evaluate the performance of…

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