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To better understand DNA's 3D folding in cell nuclei, researchers developed chromosome capture methods such as Hi-C that measure the contact frequencies between all DNA segment pairs across the genome. As Hi-C data sets often are massive,…

Biological Physics · Physics 2023-11-14 Anton Holmgren , Dolores Bernenko , Ludvig Lizana

Researchers developed chromosome capture methods such as Hi-C to better understand DNA's 3D folding in nuclei. The Hi-C method captures contact frequencies between DNA segment pairs across the genome. When analyzing Hi-C data sets, it is…

Physics and Society · Physics 2023-11-14 Dolores Bernenko , Sang Hoon Lee , Ludvig Lizana

Community detection (CD) algorithms are applied to Hi-C data to discover new communities of loci in the 3D conformation of human and mouse DNA. We find that CD has some distinct advantages over pre-existing methods: (1) it is capable of…

Genomics · Quantitative Biology 2015-09-18 Irineo Cabreros , Emmanuel Abbe , Aristotelis Tsirigos

Several experiments show that the three dimensional (3D) organization of chromosomes affects genetic processes such as transcription and gene regulation. To better understand this connection, researchers developed the Hi-C method that is…

Genomics · Quantitative Biology 2019-05-03 Sang Hoon Lee , Yeonghoon Kim , Sungmin Lee , Xavier Durang , Per Stenberg , Jae-Hyung Jeon , Ludvig Lizana

Chromosome conformation capture experiments such as Hi-C are used to map the three-dimensional spatial organization of genomes. One specific feature of the 3D organization is known as topologically associating domains (TADs), which are…

Applications · Statistics 2019-10-18 Y. X. Rachel Wang , Purnamrita Sarkar , Oana Ursu , Anshul Kundaje , Peter J. Bickel

Community and cluster detection is a popular field of social network analysis. Most algorithms focus on static graphs or series of snapshots. In this paper we present an algorithm, which detects communities in dynamic graphs. The method is…

Social and Information Networks · Computer Science 2016-01-26 Pascal Held , Rudolf Kruse

To understand the nature of a cell, one needs to understand the structure of its genome. For this purpose, experimental techniques such as Hi-C detecting chromosomal contacts are used to probe the three-dimensional genomic structure. These…

Quantitative Methods · Quantitative Biology 2019-09-23 Andreas Hofmann , Fatema Zahra Rashid , Frédéric Crémazy , Remus T. Dame , Dieter W. Heermann

Numerous networked systems feature a structure of nontrivial communities, which often correspond to their functional modules. Such communities have been detected in real-world biological, social and technological systems, as well as in…

Physics and Society · Physics 2025-07-08 Charo I. del Genio

Community detection, or clustering, identifies groups of nodes in a graph that are more densely connected to each other than to the rest of the network. Given the size and dynamic nature of real-world graphs, efficient community detection…

Social and Information Networks · Computer Science 2024-10-22 Subhajit Sahu

We describe techniques for the robust detection of community structure in some classes of time-dependent networks. Specifically, we consider the use of statistical null models for facilitating the principled identification of structural…

Data Analysis, Statistics and Probability · Physics 2013-04-16 Danielle S. Bassett , Mason A. Porter , Nicholas F. Wymbs , Scott T. Grafton , Jean M. Carlson , Peter J. Mucha

Finding community structures in social networks is considered to be a challenging task as many of the proposed algorithms are computationally expensive and does not scale well for large graphs. Most of the community detection algorithms…

Social and Information Networks · Computer Science 2023-01-30 Partha Basuchowdhuri , Satyaki Sikdar , Varsha Nagarajan , Khusbu Mishra , Surabhi Gupta , Subhashis Majumder

Detecting communities in large complex networks has found a wide range of applications in physical, biological, and social sciences by identifying mesoscopic groups based on the links between individual units. Moreover, community detection…

Pattern Formation and Solitons · Physics 2024-05-15 Michelle Kovarik , Tyler Allcroft , Per Sebastian Skardal

Discovering and tracking communities in time-varying networks is an important task in network science, motivated by applications in fields ranging from neuroscience to sociology. In this work, we characterize the celebrated family of…

Social and Information Networks · Computer Science 2024-12-11 Jacob Hume , Laura Balzano

Complex data in social and natural sciences find effective representation through networks, wherein quantitative and categorical information can be associated with nodes and connecting edges. The internal structure of networks can be…

Social and Information Networks · Computer Science 2024-08-07 Fabio Morea , Domenico De Stefano

Hidden community is a new graph-theoretical concept recently proposed [4], in which the authors also propose a meta-approach called HICODE (Hidden Community Detection) for detecting hidden communities. HICODE is demonstrated through…

Social and Information Networks · Computer Science 2020-03-16 Jialu Bao , Kun He , Xiaodong Xin , Bart Selman , John E. Hopcroft

Recent years have seen a surge of interest in the analysis of complex networks, facilitated by the availability of relational data and the increasingly powerful computational resources that can be employed for their analysis. Naturally, the…

Physics and Society · Physics 2013-08-08 Jean-Charles Delvenne , Michael T. Schaub , Sophia N. Yaliraki , Mauricio Barahona

Community detection is a commonly used technique for identifying groups in a network based on similarities in connectivity patterns. To facilitate community detection in large networks, we recast the network to be partitioned into a smaller…

Social and Information Networks · Computer Science 2017-06-14 Natalie Stanley , Roland Kwitt , Marc Niethammer , Peter J. Mucha

Complex networks represent interactions between entities. They appear in various contexts such as sociology, biology, etc., and they generally contain highly connected subgroups called communities. Community detection is a well-studied…

Social and Information Networks · Computer Science 2014-06-11 Romain Campigotto , Patricia Conde Céspedes , Jean-Loup Guillaume

This paper considers a new framework to detect communities in a graph from the observation of signals at its nodes. We model the observed signals as noisy outputs of an unknown network process, represented as a graph filter that is excited…

Social and Information Networks · Computer Science 2019-04-16 Hoi-To Wai , Santiago Segarra , Asuman E. Ozdaglar , Anna Scaglione , Ali Jadbabaie

Dynamic heterogeneous networks describe the temporal evolution of interactions among nodes and edges of different types. While there is a rich literature on finding communities in dynamic networks, the application of these methods to…

Computation · Statistics 2022-11-01 Maoyu Zhang , Jingfei Zhang , Wenlin Dai
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