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The analysis of the tumor environment on digital histopathology slides is becoming key for the understanding of the immune response against cancer, supporting the development of novel immuno-therapies. We introduce here a novel deep…

Image and Video Processing · Electrical Eng. & Systems 2019-06-27 Ansh Kapil , Tobias Wiestler , Simon Lanzmich , Abraham Silva , Keith Steele , Marlon Rebelatto , Guenter Schmidt , Nicolas Brieu

In this paper, we use partially rank-ordered set (PROS) sampling design with multiple concomitants in a breast cancer study and propose a method to estimate the proportion of patients with malignant (cancerous) breast tumours in a given…

Methodology · Statistics 2014-11-11 Armin Hatefi , Mohammad Jafari Jozani

Label Proportion Learning (LLP) addresses the classification problem where multiple instances are grouped into bags and each bag contains information about the proportion of each class. However, in practical applications, obtaining precise…

Machine Learning · Computer Science 2025-07-15 Jiahe Qin , Junpeng Li , Changchun Hua , Yana Yang

The tumor-immune system plays a critical role in colorectal cancer progression. Recent preclinical and clinical studies showed that combination therapy with anti-PD-L1 and cancer vaccines improved treatment response. In this study, we…

Populations and Evolution · Quantitative Biology 2026-02-06 Chenghang Li , Haifeng Zhang , Xiulan Lai , Jinzhi Lei

Semi-supervised learning (SSL) often suffers under class imbalance, where pseudo-labeling amplifies majority bias and suppresses minority performance. We address this issue with a lightweight framework that, to our knowledge, is the first…

Machine Learning · Computer Science 2026-03-04 Kohki Akiba , Shinnosuke Matsuo , Shota Harada , Ryoma Bise

One of the most challenges in medical imaging is the lack of data and annotated data. It is proven that classical segmentation methods such as U-NET are useful but still limited due to the lack of annotated data. Using a weakly supervised…

Image and Video Processing · Electrical Eng. & Systems 2020-03-20 Amine Amyar , Romain Modzelewski , Pierre Vera , Vincent Morard , Su Ruan

Semi-supervised segmentation tackles the scarcity of annotations by leveraging unlabeled data with a small amount of labeled data. A prominent way to utilize the unlabeled data is by consistency training which commonly uses a…

Computer Vision and Pattern Recognition · Computer Science 2022-03-14 Sukesh Adiga , Jose Dolz , Herve Lombaert

We propose a learning algorithm capable of learning from label proportions instead of direct data labels. In this scenario, our data are arranged into various bags of a certain size, and only the proportions of each label within a given bag…

Machine Learning · Computer Science 2019-06-27 Gabriel Dulac-Arnold , Neil Zeghidour , Marco Cuturi , Lucas Beyer , Jean-Philippe Vert

This paper presents a novel method for unsupervised segmentation of pathology images. Staging of lung cancer is a major factor of prognosis. Measuring the maximum dimensions of the invasive component in a pathology images is an essential…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Takayasu Moriya , Holger R. Roth , Shota Nakamura , Hirohisa Oda , Kai Nagara , Masahiro Oda , Kensaku Mori

The learning curve expresses the error rate of a predictive modeling procedure as a function of the sample size of the training dataset. It typically is a decreasing, convex function with a positive limiting value. An estimate of the…

Applications · Statistics 2012-03-14 Eric B. Laber , Kerby Shedden , Yang Yang

We investigate Learning from Label Proportions (LLP), a partial information setting where examples in a training set are grouped into bags, and only aggregate label values in each bag are available. Despite the partial observability, the…

Machine Learning · Computer Science 2025-06-02 Robert Busa-Fekete , Travis Dick , Claudio Gentile , Haim Kaplan , Tomer Koren , Uri Stemmer

Learning from Label Proportions (LLP) is an established machine learning problem with numerous real-world applications. In this setting, data items are grouped into bags, and the goal is to learn individual item labels, knowing only the…

Machine Learning · Computer Science 2023-10-31 Gabriel Franco , Giovanni Comarela , Mark Crovella

Estimating the log-likelihood of a given sentence under an autoregressive language model is straightforward: one can simply apply the chain rule and sum the log-likelihood values for each successive token. However, for masked language…

Computation and Language · Computer Science 2023-05-24 Carina Kauf , Anna Ivanova

In learning from label proportions (LLP), the instances are grouped into bags, and the task is to learn an instance classifier given relative class proportions in training bags. LLP is useful when obtaining individual instance labels is…

Machine Learning · Computer Science 2022-11-01 Denis Baručić , Jan Kybic

The deployment of Machine Learning models intraoperatively for tissue characterisation can assist decision making and guide safe tumour resections. For image classification models, pixel attribution methods are popular to infer…

Computer Vision and Pattern Recognition · Computer Science 2025-08-01 Alfie Roddan , Chi Xu , Serine Ajlouni , Irini Kakaletri , Patra Charalampaki , Stamatia Giannarou

Positive--unlabeled (PU) learning considers two samples, a positive set P with observations from only one class and an unlabeled set U with observations from two classes. The goal is to classify observations in U. Class mixture proportion…

Methodology · Statistics 2020-01-13 Zhenfeng Lin , James P. Long

A constrained L1 minimization method is proposed for estimating a sparse inverse covariance matrix based on a sample of $n$ iid $p$-variate random variables. The resulting estimator is shown to enjoy a number of desirable properties. In…

Methodology · Statistics 2011-02-14 Tony Cai , Weidong Liu , Xi Luo

Increased levels of tumor infiltrating lymphocytes (TILs) in cancer tissue indicate favourable outcomes in many types of cancer. Manual quantification of immune cells is inaccurate and time consuming for pathologists. Our aim is to leverage…

Learning from label proportions (LLP) is a weakly supervised setting for classification in which unlabeled training instances are grouped into bags, and each bag is annotated with the proportion of each class occurring in that bag. Prior…

Machine Learning · Statistics 2020-06-15 Clayton Scott , Jianxin Zhang

Purpose: Cell size is a fundamental characteristic of all tissues, and changes in cell size in cancer reflect tumor status and response to treatments, such as apoptosis and cell cycle arrest. Unfortunately, cell size can only be obtained by…