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Individual components such as cells, particles, or agents within a larger system often require detailed understanding of their relative position to act accordingly, enabling the system as a whole to function in an organised and efficient…

Statistical Mechanics · Physics 2025-02-28 Jonas Berx , Prashant Singh , Karel Proesmans

Biomolecules stochastically occupy different possible configurations with probabilities given by non-equilibrium steady-state distributions. These distributions are determined by the transition rate constants between different…

Biological Physics · Physics 2024-07-19 Easun Arunachalam , Milo M. Lin

Position determination in biological systems is often achieved through protein concentration gradients. Measuring the local concentration of such a protein with a spatially-varying distribution allows the measurement of position within the…

Subcellular Processes · Quantitative Biology 2007-05-23 Filipe Tostevin , Pieter Rein ten Wolde , Martin Howard

Cells in a developing embryo have no direct way of "measuring" their physical position. Through a variety of processes, however, the expression levels of multiple genes come to be correlated with position, and these expression levels thus…

Molecular Networks · Quantitative Biology 2012-01-04 Julien O. Dubuis , Gasper Tkacik , Eric F. Wieschaus , Thomas Gregor , William Bialek

The concept of positional information is central to our understanding of how cells in a multicellular structure determine their developmental fates. Nevertheless, positional information has neither been defined mathematically nor quantified…

Biological Physics · Physics 2014-04-23 Gašper Tkačik , Julien O Dubuis , Mariela D Petkova , Thomas Gregor

Life on earth is distinguished by long-lived correlations in time. The patterns of material organization that characterize living organisms today are contingent on events that occurred billions of years ago. This contingency is a necessary…

Soft Condensed Matter · Physics 2021-01-06 Peter M. Tzelios , Kyle J. M. Bishop

In the stochastic formulation of chemical kinetics, the stationary moments of the population count of species can be described via a set of linear equations. However, except for some specific cases such as systems with linear reaction…

Quantitative Methods · Quantitative Biology 2017-01-02 Khem Raj Ghusinga , Cesar A. Vargas-Garcia , Andrew Lamperski , Abhyudai Singh

The use of fully or partially absorbing boundary conditions for diffusion-based problems has become paradigmatic in physical chemistry and biochemistry to describe reactions occurring in solutions or in living media. However, as chemical…

Statistical Mechanics · Physics 2022-12-13 Francesco Piazza

Stochastic boundary conditions for interactions with a particle reservoir are discussed in many-particle systems. We introduce the boundary conditions with the injection rate and the momentum distribution of particles coming from a particle…

Statistical Mechanics · Physics 2017-04-26 Tooru Taniguchi , Shin-ichi Sawada

We investigate the maximum caliber variational principle as an inference algorithm used to predict dynamical properties of complex nonequilibrium, stationary, statistical systems in the presence of incomplete information. Specifically, we…

Statistical Mechanics · Physics 2016-12-28 Carlo Cafaro , Sean Alan Ali

Active control of quantum systems enables diverse applications ranging from quantum computation to manipulation of molecular processes. Maximum speeds and related bounds have been identified from uncertainty principles and related…

Quantum Physics · Physics 2021-09-15 Hanwen Zhang , Zeyu Kuang , Shruti Puri , Owen D. Miller

We propose predictive information, that is information between a long past of duration T and the entire infinitely long future of a time series, as a universal order parameter to study phase transitions in physical systems. It can be used,…

Statistical Mechanics · Physics 2014-02-04 Martin Tchernookov , Ilya Nemenman

Information must take up space, must weigh, and its flux must be limited. Quantum limits on communication and information storage leading to these conclusions are here described. Quantum channel capacity theory is reviewed for both steady…

Quantum Physics · Physics 2015-06-26 Jacob D. Bekenstein , Marcelo Schiffer

We use colloidal suspensions encapsulated in emulsion droplets to model confined glass-forming liquids with tunable boundary mobility. We show dynamics in these idealized systems are governed by physical interactions with the boundary.…

Soft Condensed Matter · Physics 2014-05-29 Gary L. Hunter , Kazem V. Edmond , Eric R. Weeks

We study whether the stationary state of two bulk-driven systems slowly exchanging particles can be described by the equality of suitably defined nonequilibrium chemical potentials. Our main result is that in a weak contact limit, chemical…

Statistical Mechanics · Physics 2018-08-29 Jules Guioth , Éric Bertin

Information theory, rooted in computer science, and many-body physics, have traditionally been studied as (almost) independent fields. Only recently has this paradigm started to shift, with many-body physics being studied and characterized…

Disordered Systems and Neural Networks · Physics 2024-02-20 Noa Feldman , Niv Davidson , Moshe Goldstein

Flow-fields are ubiquitous systems that are able to transport vital signalling molecules necessary for system function. While information regarding the location and transport of such particles is often crucial, it is not well-understood how…

Statistical Mechanics · Physics 2020-09-02 Evelyn Tang , Ramin Golestanian

According to the universal entropy bound, the entropy (and hence information capacity) of a complete weakly self-gravitating physical system can be bounded exclusively in terms of its circumscribing radius and total gravitating energy. The…

Quantum Physics · Physics 2009-11-10 Jacob D. Bekenstein

In many developmental systems, cells differentiate into a tissue by reading out morphogen concentration fields, a process fundamentally limited by noise. How much can the precision of this process be improved by nonlocal information, e.g.,…

Biological Physics · Physics 2025-12-24 Alex Chen Yi Zhang , Pablo Mateu Hoyos , David Brückner , Gašper Tkačik

Machine learning has proven to be a valuable tool to approximate functions in high-dimensional spaces. Unfortunately, analysis of these models to extract the relevant physics is never as easy as applying machine learning to a large dataset…

Materials Science · Physics 2020-05-06 Conrad W. Rosenbrock , Eric R. Homer , Gábor Csányi , Gus L. W. Hart
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