Related papers: Robust Optimization for Spot Scanning Proton Thera…
Stereotactic body radiation therapy (SBRT) and hypofractionation using pencil-beam scanning (PBS) proton therapy (PBSPT) is an attractive option for thoracic malignancies. Combining the advantages of target coverage conformity and critical…
Proton beam therapy has been developed to irradiate the tumor with higher precision and dose conformity compared to conventional X-ray irradiation. The dose conformity of this treatment modality may be further improved if narrower proton…
We propose a novel optimization model for volumetric modulated arc therapy (VMAT) planning that directly optimizes deliverable leaf trajectories in the treatment plan optimization problem, and eliminates the need for a separate…
Accurate dose calculation on cone beam computed tomography (CBCT) images is essential for modern proton treatment planning workflows, particularly when accounting for inter-fractional anatomical changes in adaptive treatment scenarios.…
During Stereotactic Body Radiotherapy (SBRT) for the treatment of prostate cancer, an inflatable endorectal balloon (ERB) may be used to reduce motion of the target and reduce the dose to the posterior rectal wall. This work assessed the…
Low-dose computed tomography (LDCT) is critical for minimizing radiation exposure, but it often leads to increased noise and reduced image quality. Traditional denoising methods, such as iterative optimization or supervised learning, often…
When treating moving tumors, the precise delivery of proton therapy by pencil beam scanning (PBS) is challenged by the interplay effect. Although several 4D-optimization methods have been proposed, what is the most beneficial motion…
Background: Dose calculation and optimization algorithms in proton therapy treatment planning often have high computational requirements regarding time and memory. This can hinder the implementation of efficient workflows in clinics and…
Diffusing alpha-emitters Radiation Therapy (Alpha DaRT) enables the use of alpha particles for the treatment of solid tumors. It employs interstitial sources carrying a few uCi of Ra-224, designed to release its short-lived progeny, which…
The interplay between the beam delivery time structure and the patient motion makes 4D dose calculation (4DDC) important when treating moving tumors with intensity modulated proton therapy. 4DDC based on phase sorting of a 4DCT suffers from…
Background: Intensity-modulated proton therapy (IMPT) using pencil beam technique scans tumor in a layer by layer, then spot by spot manner. It can provide highly conformal dose to tumor targets and spare nearby organs-at-risk (OAR). Fast…
Background: Spectral shaping is a computed tomography (CT) dose optimization technique that adjusts source voltage and filtration to reduce patient radiation exposure without compromising image quality. Traditionally, radiation dose has…
Proton radiography combined with X-ray computed tomography (CT) has been proposed to obtain a patient-specific calibration curve and reduce range uncertainties in cancer treatment with charged particles. The main aim of this study was to…
Distributionally Robust Optimization (DRO), as a popular method to train robust models against distribution shift between training and test sets, has received tremendous attention in recent years. In this paper, we propose and analyze…
Purpose: To evaluate the cumulative radiobiological impact of daily Megavoltage Cone-Beam Computed Tomography (MV-CBCT) imaging dose based on Normal Tissue Complication Probability (NTCP) and Excess Absolute Risk (EAR) of secondary…
Objective. As proton arc therapy (PAT) approaches clinical implementation, optimizing treatment plans for this innovative delivery modality remains challenging, especially in addressing arc delivery time. Existing algorithms for minimizing…
The determination of relative stopping power (RSP) via proton computed tomography (pCT) of a patient is dependent in part on the knowledge of the incoming proton kinetic energies; the uncertainty in these energies is in turn determined by…
Purpose: Dual-energy CT (DECT) has been shown to derive stopping power ratio (SPR) map with higher accuracy than conventional single energy CT (SECT) by obtaining the energy dependence of photon interactions. However, DECT is not as widely…
Prostate cancer is one of the most prevalent and deadly cancers among men, motivating the development of accurate and accessible imaging technologies for early detection. Ultrasound computed tomography (USCT) reconstructs quantitative…
Purpose: Patient-specific ridge filters can modulate proton energy to obtain a conformal dose. We describe a new framework for optimization of filter design and spot maps to meet the unique demands of FLASH radiotherapy. We demonstrate an…