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The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across…

Machine Learning · Computer Science 2023-02-01 Jin Li , Benjamin J. Cairns , Jingsong Li , Tingting Zhu

Deep learning model effectiveness in classification tasks is often challenged by the quality and quantity of training data whenever they are affected by strong spurious correlations between specific attributes and target labels. This…

Machine learning heavily relies on data, but real-world applications often encounter various data-related issues. These include data of poor quality, insufficient data points leading to under-fitting of machine learning models, and…

Machine Learning · Computer Science 2025-04-07 Yingzhou Lu , Lulu Chen , Yuanyuan Zhang , Minjie Shen , Huazheng Wang , Xiao Wang , Capucine van Rechem , Tianfan Fu , Wenqi Wei

Recent advances in generative modelling have led many to see synthetic data as the go-to solution for a range of problems around data access, scarcity, and under-representation. In this paper, we study three prominent use cases: (1) Sharing…

Machine Learning · Computer Science 2026-02-04 Bogdan Kulynych , Theresa Stadler , Jean Louis Raisaro , Carmela Troncoso

Learning from a large corpus of data, pre-trained models have achieved impressive progress nowadays. As popular generative pre-training, diffusion models capture both low-level visual knowledge and high-level semantic relations. In this…

Computer Vision and Pattern Recognition · Computer Science 2023-03-20 Chaofan Ma , Yuhuan Yang , Chen Ju , Fei Zhang , Jinxiang Liu , Yu Wang , Ya Zhang , Yanfeng Wang

The growing demand for diverse and high-quality facial datasets for training and testing biometric systems is challenged by privacy regulations, data scarcity, and ethical concerns. Synthetic facial images offer a potential solution, yet…

Computer Vision and Pattern Recognition · Computer Science 2026-01-26 Ananya Kadali , Sunnie Jehan-Morrison , Orasiki Wellington , Barney Evans , Precious Durojaiye , Richard Guest

Magnetic resonance (MR) imaging, including cardiac MR, is prone to domain shift due to variations in imaging devices and acquisition protocols. This challenge limits the deployment of trained AI models in real-world scenarios, where…

Computer Vision and Pattern Recognition · Computer Science 2025-08-11 Xin Ci Wong , Duygu Sarikaya , Kieran Zucker , Marc De Kamps , Nishant Ravikumar

Identifying novel drug-target interactions (DTI) is a critical and rate limiting step in drug discovery. While deep learning models have been proposed to accelerate the identification process, we show that state-of-the-art models fail to…

Weed management plays an important role in many modern agricultural applications. Conventional weed control methods mainly rely on chemical herbicides or hand weeding, which are often cost-ineffective, environmentally unfriendly, or even…

Computer Vision and Pattern Recognition · Computer Science 2022-10-19 Dong Chen , Xinda Qi , Yu Zheng , Yuzhen Lu , Zhaojian Li

Despite continued advancement in recent years, deep neural networks still rely on large amounts of training data to avoid overfitting. However, labeled training data for real-world applications such as healthcare is limited and difficult to…

Acquiring large quantities of data and annotations is known to be effective for developing high-performing deep learning models, but is difficult and expensive to do in the healthcare context. Adding synthetic training data using generative…

Image and Video Processing · Electrical Eng. & Systems 2023-10-06 Menghan Yu , Sourabh Kulhare , Courosh Mehanian , Charles B Delahunt , Daniel E Shea , Zohreh Laverriere , Ishan Shah , Matthew P Horning

With the rising adoption of Machine Learning across the domains like banking, pharmaceutical, ed-tech, etc, it has become utmost important to adopt responsible AI methods to ensure models are not unfairly discriminating against any group.…

Machine Learning · Computer Science 2022-12-02 Bhushan Chaudhari , Himanshu Chaudhary , Aakash Agarwal , Kamna Meena , Tanmoy Bhowmik

Designing protein binders targeting specific sites, which requires to generate realistic and functional interaction patterns, is a fundamental challenge in drug discovery. Current structure-based generative models are limited in generating…

Machine Learning · Computer Science 2025-10-17 Zishen Zhang , Xiangzhe Kong , Wenbing Huang , Yang Liu

Graph neural networks (GNNs) have emerged as one of the most effective ML techniques for drug effect prediction from drug molecular graphs. Despite having immense potential, GNN models lack performance when using datasets that contain…

Machine Learning · Computer Science 2024-10-15 Avishek Bose , Guojing Cong

Faced with the challenges of patient confidentiality and scientific reproducibility, research on machine learning for health is turning towards the conception of synthetic medical databases. This article presents a brief overview of…

Modern datasets in neuroscience enable unprecedented inquiries into the relationship between complex behaviors and the activity of many simultaneously recorded neurons. While latent variable models can successfully extract low-dimensional…

Neurons and Cognition · Quantitative Biology 2024-12-03 Jaivardhan Kapoor , Auguste Schulz , Julius Vetter , Felix Pei , Richard Gao , Jakob H. Macke

Generative Adversarial Networks (GANs) have been used in many different applications to generate realistic synthetic data. We introduce a novel GAN with Autoencoder (GAN-AE) architecture to generate synthetic samples for variable length,…

Machine Learning · Computer Science 2022-10-10 Stephanie Ger , Yegna Subramanian Jambunath , Diego Klabjan

Variable selection for high-dimensional, highly correlated data has long been a challenging problem, often yielding unstable and unreliable models. We propose a resample-aggregate framework that exploits diffusion models' ability to…

Methodology · Statistics 2025-08-20 Minjie Wang , Xiaotong Shen , Wei Pan

The increased demand for 3D data in AR/VR, robotics and gaming applications, gave rise to powerful generative pipelines capable of synthesizing high-quality 3D objects. Most of these models rely on the Score Distillation Sampling (SDS)…

Computer Vision and Pattern Recognition · Computer Science 2023-12-12 Ziyu Wan , Despoina Paschalidou , Ian Huang , Hongyu Liu , Bokui Shen , Xiaoyu Xiang , Jing Liao , Leonidas Guibas

The scarcity of large-scale palmprint databases poses a significant bottleneck to advancements in contactless palmprint recognition. To address this, researchers have turned to synthetic data generation. While Generative Adversarial…

Computer Vision and Pattern Recognition · Computer Science 2024-06-04 Steven A. Grosz , Anil K. Jain