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Large language models (LLMs) in biomedicine face a fundamental conflict between static parameter knowledge and the dynamic nature of clinical evidence. Retrieval-Augmented Generation (RAG) addresses this by grounding generation in external…

Other Quantitative Biology · Quantitative Biology 2025-12-19 Jiawei He , Boya Zhang , Hossein Rouhizadeh , Yingjian Chen , Rui Yang , Jin Lu , Xudong Chen , Nan Liu , Douglas Teodoro

There are two common ways in which developers are incorporating proprietary and domain-specific data when building applications of Large Language Models (LLMs): Retrieval-Augmented Generation (RAG) and Fine-Tuning. RAG augments the prompt…

The deployment of Multimodal Large Language Models (MLLMs) in agriculture is currently stalled by a critical trade-off: the existing literature lacks the large-scale agricultural datasets required for robust model development and…

Computer Vision and Pattern Recognition · Computer Science 2026-03-19 Abderrahmene Boudiaf , Irfan Hussain , Sajid Javed

New technologies in generative AI can enable deeper analysis into our nation's supply chains but truly informative insights require the continual updating and aggregation of massive data in a timely manner. Large Language Models (LLMs)…

Coffee yields are contingent on the timely and accurate diagnosis of diseases; however, assessing leaf diseases in the field presents significant challenges. Although Artificial Intelligence (AI) vision models achieve high accuracy, their…

Computer Vision and Pattern Recognition · Computer Science 2026-01-21 Larissa Ferreira Rodrigues Moreira , Rodrigo Moreira , Leonardo Gabriel Ferreira Rodrigues

Retrieval-Augmented Generation (RAG) lifts the factuality of Large Language Models (LLMs) by injecting external knowledge, yet it falls short on problems that demand multi-step inference; conversely, purely reasoning-oriented approaches…

Retrieval-Augmented Generation (RAG) enhances large language models (LLMs) by integrating up-to-date external knowledge, yet real-world web environments present unique challenges. These limitations manifest as two key challenges: pervasive…

Information Retrieval · Computer Science 2026-03-24 Yuqin Dai , Shuo Yang , Guoqing Wang , Yong Deng , Zhanwei Zhang , Jun Yin , Pengyu Zeng , Zhenzhe Ying , Changhua Meng , Can Yi , Yuchen Zhou , Weiqiang Wang , Shuai Lu

Large Language Models (LLMs) have exhibited remarkable proficiency in natural language understanding, prompting extensive exploration of their potential applications across diverse domains. In the medical domain, open-source LLMs have…

Computation and Language · Computer Science 2024-08-01 Cui Long , Yongbin Liu , Chunping Ouyang , Ying Yu

Recent developments in large language models (LLMs) have led to significant improvements in intelligent dialogue systems'ability to handle complex inquiries. However, current LLMs still exhibit limitations in specialized domain knowledge,…

Computation and Language · Computer Science 2024-09-23 Shuting Yang , Zehui Liu , Wolfgang Mayer

The data and compute requirements of current language modeling technology pose challenges for the processing and analysis of low-resource languages. Declarative linguistic knowledge has the potential to partially bridge this data scarcity…

Computation and Language · Computer Science 2024-10-02 Bhargav Shandilya , Alexis Palmer

Large Language Models (LLMs) have demonstrated impressive capabilities across natural language processing tasks. However, their application to specialized domains such as medicine and biology requires further optimization to ensure factual…

Computation and Language · Computer Science 2025-02-06 Seonok Kim

Recent advances in large language models (LLMs) have shown great potential to accelerate drug discovery. However, the specialized nature of biochemical data often necessitates costly domain-specific fine-tuning, posing major challenges.…

Machine Learning · Computer Science 2025-11-17 Namkyeong Lee , Edward De Brouwer , Ehsan Hajiramezanali , Tommaso Biancalani , Chanyoung Park , Gabriele Scalia

Large Language Models (LLMs) have enabled a wide range of applications through their powerful capabilities in language understanding and generation. However, as LLMs are trained on static corpora, they face difficulties in addressing…

Computation and Language · Computer Science 2025-10-13 Yongjie Wang , Yue Yu , Kaisong Song , Jun Lin , Zhiqi Shen

While large language models (LLMs) have achieved remarkable success in providing trustworthy responses for knowledge-intensive tasks, they still face critical limitations such as hallucinations and outdated knowledge. To address these…

Computation and Language · Computer Science 2025-08-06 Zizhong Li , Haopeng Zhang , Jiawei Zhang

The Adobe Experience Platform AI Assistant is a conversational tool that enables organizations to interact seamlessly with proprietary enterprise data through a chatbot. However, due to access restrictions, Large Language Models (LLMs)…

Information Retrieval · Computer Science 2025-02-24 Manisha Mukherjee , Sungchul Kim , Xiang Chen , Dan Luo , Tong Yu , Tung Mai

Weeds significantly reduce crop yields worldwide and pose major challenges to sustainable agriculture. Traditional weed management methods, primarily relying on chemical herbicides, risk environmental contamination and lead to the emergence…

Computer Vision and Pattern Recognition · Computer Science 2025-11-12 Charalampos S. Kouzinopoulos , Yuri Manna

Large language models (LLMs) are transforming the landscape of medicine, yet two fundamental challenges persist: keeping up with rapidly evolving medical knowledge and providing verifiable, evidence-grounded reasoning. Retrieval-augmented…

The collection of high-resolution training data is crucial in building robust plant disease diagnosis systems, since such data have a significant impact on diagnostic performance. However, they are very difficult to obtain and are not…

Computer Vision and Pattern Recognition · Computer Science 2020-10-14 Quan Huu Cap , Hiroki Tani , Hiroyuki Uga , Satoshi Kagiwada , Hitoshi Iyatomi

Retrieval-augmented generation (RAG) systems can effectively mitigate the hallucination problem of large language models (LLMs),but they also possess inherent vulnerabilities. Identifying these weaknesses before the large-scale real-world…

Information Retrieval · Computer Science 2025-05-23 Hongru Song , Yu-an Liu , Ruqing Zhang , Jiafeng Guo , Yixing Fan

Deploying Large Language Model (LLM) applications, particularly those relying on Retrieval-Augmented Generation (RAG), remains challenging due to high computational demands, outdated knowledge bases, and the need to manually select optimal…

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