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We present a continuous threshold model (CTM) of cascade dynamics for a network of agents with real-valued activity levels that change continuously in time. The model generalizes the linear threshold model (LTM) from the literature, where…

Optimization and Control · Mathematics 2020-07-07 Yaofeng Desmond Zhong , Naomi Ehrich Leonard

Neural approaches to sequence labeling often use a Conditional Random Field (CRF) to model their output dependencies, while Recurrent Neural Networks (RNN) are used for the same purpose in other tasks. We set out to establish RNNs as an…

Machine Learning · Computer Science 2018-10-02 Saeed Najafi , Colin Cherry , Grzegorz Kondrak

Stochastic Chemical Reaction Networks are continuous time Markov chain models that describe the time evolution of the molecular counts of species interacting stochastically via discrete reactions. Such models are ubiquitous in systems and…

Quantitative Methods · Quantitative Biology 2024-02-01 Theodore W. Grunberg , Domitilla Del Vecchio

Growing evidence has indicated that the global composition distribution plays an indisputable role in interpreting observational data. 3D general circulation models (GCMs) with a reliable treatment of chemistry and clouds are particularly…

Earth and Planetary Astrophysics · Physics 2022-08-10 Shang-Min Tsai , Elspeth K. H. Lee , Raymond Pierrehumbert

Accurately modeling chemical reactions at the atomistic level requires high-level electronic structure theory due to the presence of unpaired electrons and the need to properly describe bond breaking and making energetics. Commonly used…

The simulation of molecules is a widely anticipated application of quantum computers. However, recent studies \cite{WBCH13a,HWBT14a} have cast a shadow on this hope by revealing that the complexity in gate count of such simulations…

Quantum Physics · Physics 2015-10-05 David Poulin , M. B. Hastings , Dave Wecker , Nathan Wiebe , Andrew C. Doherty , Matthias Troyer

The behavior of some stochastic chemical reaction networks is largely unaffected by slight inaccuracies in reaction rates. We formalize the robustness of state probabilities to reaction rate deviations, and describe a formal connection…

Computational Complexity · Computer Science 2009-01-28 David Soloveichik

Speech enhancement has benefited from the success of deep learning in terms of intelligibility and perceptual quality. Conventional time-frequency (TF) domain methods focus on predicting TF-masks or speech spectrum, via a naive convolution…

Audio and Speech Processing · Electrical Eng. & Systems 2020-09-24 Yanxin Hu , Yun Liu , Shubo Lv , Mengtao Xing , Shimin Zhang , Yihui Fu , Jian Wu , Bihong Zhang , Lei Xie

Biochemical reactions typically occur at low copy numbers, but at once in crowded and diverse environments. Space and stochasticity therefore play an essential role in biochemical networks. Spatial-stochastic simulations have become a…

Finding synthesis routes for molecules of interest is an essential step in the discovery of new drugs and materials. To find such routes, computer-assisted synthesis planning (CASP) methods are employed which rely on a model of chemical…

HCN is a key ingredient for synthesizing biomolecules such as nucleobases and amino acids. We calculate 42 reaction rate coefficients directly involved with or in competition with the production of HCN in the early Earth or Titan…

Earth and Planetary Astrophysics · Physics 2019-03-12 Ben K. D. Pearce , Paul W. Ayers , Ralph E. Pudritz

Threshold networks are used as models for neural or gene regulatory networks. They show a rich dynamical behaviour with a transition between a frozen and a chaotic phase. We investigate the phase diagram of randomly connected threshold…

Statistical Mechanics · Physics 2009-11-13 Agnes Szejka , Tamara Mihaljev , Barbara Drossel

Stochastic chemical reaction networks (SRNs) in cellular systems are commonly modeled as continuous-time Markov chains (CTMCs) describing the dynamics of molecular copy numbers. The exact evaluation of transient copy number statistics is,…

Quantitative Methods · Quantitative Biology 2026-04-07 Takeyuki Iwasaki , Yutaka Hori

In this paper, a new fractional step method is proposed for simulating stiff and nonstiff chemically reacting flows. In stiff cases, a well-known spurious numerical phenomenon, i.e. the incorrect propagation speed of discontinuities, may be…

Computational Physics · Physics 2019-05-01 Jian-Hang Wang , Shucheng Pan , Xiangyu Y. Hu , Nikolaus A. Adams

Benchmark reactions involving molecular hydrogen, such as H$_2$+D or H$_2$+Cl, provide the ideal platforms to investigate the effect of Near Threshold Resonances (NTR) on scattering processes. Due to the small reduced mass of those systems,…

Atomic Physics · Physics 2017-10-25 D. Shu , I. Simbotin , R. Côté

Recent research into analog computing has introduced new notions of computing real numbers. Huang, Klinge, Lathrop, Li, and Lutz defined a notion of computing real numbers in real-time with chemical reaction networks (CRNs), introducing the…

Emerging Technologies · Computer Science 2021-09-08 Willem Fletcher , Titus H. Klinge , James I. Lathrop , Dawn A. Nye , Matthew Rayman

Hebbian theory seeks to explain how the neurons in the brain adapt to stimuli, to enable learning. An interesting feature of Hebbian learning is that it is an unsupervised method and as such, does not require feedback, making it suitable in…

Neurons and Cognition · Quantitative Biology 2022-06-07 Jakub Fil , Neil Dalchau , Dominique Chu

We extend the traditional framework of steady state energy transduction -- typically characterized by a single input and output -- to multi-resource transduction in open chemical reaction networks (CRNs). Transduction occurs when…

Molecular Networks · Quantitative Biology 2025-07-24 Massimo Bilancioni , Massimiliano Esposito

Cycles, which can be found in many different kinds of networks, make the problems more intractable, especially when dealing with dynamical processes on networks. On the contrary, tree networks in which no cycle exists, are simplifications…

Physics and Society · Physics 2021-04-07 Wenjun Zhang , Wei Li , Weibing Deng

Despite rapid improvements in the performance of central processing unit (CPU), the calculation cost of simulating chemically reacting flow using CFD remains infeasible in many cases. The application of the convolutional neural networks…

Machine Learning · Computer Science 2023-07-26 Joongoo Jeon , Juhyeong Lee , Sung Joong Kim