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People are living longer than ever before, and with this arises new complications and challenges for humanity. Among the most pressing of these challenges is of understanding the role of aging in the development of dementia. This paper is…

Methodology · Statistics 2018-08-07 Jonathan P Williams , Curtis B Storlie , Terry M Therneau , Clifford R Jack , Jan Hannig

With the rapid advancements in machine learning, models have become increasingly capable of learning and making predictions in various industries. However, deploying these models in critical infrastructures presents a major challenge, as…

Cryptography and Security · Computer Science 2025-11-13 Zeinab Elkhatib , Ali Sekmen , Kamrul Hasan

Hidden Markov Models (HMM) model a sequence of observations that are dependent on a hidden (or latent) state that follow a Markov chain. These models are widely used in diverse fields including ecology, speech recognition, and…

Optimization and Control · Mathematics 2024-09-05 Sidonie Foulon , Thérèse Truong , Anne-Louise Leutenegger , Hervé Perdry

Solid-state nanopores have received substantial attention in the past years owing to their simplicity and potential applications expected in genomics, sensing, archival information storage, and computing. The underlying sensing technique of…

Biological Physics · Physics 2025-08-27 Muhammad Sajeer P , Manoj M. Varma

Deep Neural Network--Hidden Markov Model (DNN-HMM) based methods have been successfully used for many always-on keyword spotting algorithms that detect a wake word to trigger a device. The DNN predicts the state probabilities of a given…

Sound · Computer Science 2021-03-01 Ashish Shrivastava , Arnav Kundu , Chandra Dhir , Devang Naik , Oncel Tuzel

Context modeling is essential in learned image compression for accurately estimating the distribution of latents. While recent advanced methods have expanded context modeling capacity, they still struggle to efficiently exploit long-range…

Image and Video Processing · Electrical Eng. & Systems 2025-07-28 Yuqi Li , Haotian Zhang , Li Li , Dong Liu

Recognition of Handwritten Mathematical Expressions (HMEs) is a challenging problem because of the ambiguity and complexity of two-dimensional handwriting. Moreover, the lack of large training data is a serious issue, especially for…

Computer Vision and Pattern Recognition · Computer Science 2019-01-23 Anh Duc Le , Bipin Indurkhya , Masaki Nakagawa

We consider a method for approximate inference in hidden Markov models (HMMs). The method circumvents the need to evaluate conditional densities of observations given the hidden states. It may be considered an instance of Approximate…

Computation · Statistics 2012-06-25 James S. Martin , Ajay Jasra , Sumeetpal S. Singh , Nick Whiteley , Emma McCoy

Case-based Reasoning (CBR) on high-dimensional and heterogeneous data is a trending yet challenging and computationally expensive task in the real world. A promising approach is to obtain low-dimensional hash codes representing cases and…

Information Retrieval · Computer Science 2022-06-30 Qi Zhang , Liang Hu , Chongyang Shi , Ke Liu , Longbing Cao

Modern deep neural networks remain challenging to interpret due to the opacity of their latent representations, impeding model understanding, debugging, and debiasing. Concept Embedding Models (CEMs) address this by mapping inputs to…

Machine Learning · Computer Science 2026-03-02 Oscar Hill , Mateo Espinosa Zarlenga , Mateja Jamnik

This paper is concerned with the computational complexity of learning the Hidden Markov Model (HMM). Although HMMs are some of the most widely used tools in sequential and time series modeling, they are cryptographically hard to learn in…

Machine Learning · Computer Science 2024-02-27 Sham M. Kakade , Akshay Krishnamurthy , Gaurav Mahajan , Cyril Zhang

Malware classification is an important and challenging problem in information security. Modern malware classification techniques rely on machine learning models that can be trained on features such as opcode sequences, API calls, and byte…

Cryptography and Security · Computer Science 2021-03-05 Aparna Sunil Kale , Fabio Di Troia , Mark Stamp

Molecular simulations have assumed a paramount role in the fields of chemistry, biology, and material sciences, being able to capture the intricate dynamic properties of systems. Within this realm, coarse-grained (CG) techniques have…

Chemical Physics · Physics 2026-03-06 Daniele Angioletti , Stefano Raniolo , Vittorio Limongelli

The advent of high-throughput sequencing technologies has revolutionized genome analysis by enabling the rapid and cost-effective sequencing of large genomes. Despite these advancements, the increasing complexity and volume of genomic data…

Genomics · Quantitative Biology 2025-03-06 Can Firtina

Hidden Markov Models (HMMs) can be accurately approximated using co-occurrence frequencies of pairs and triples of observations by using a fast spectral method in contrast to the usual slow methods like EM or Gibbs sampling. We provide a…

Machine Learning · Statistics 2012-03-29 Dean P. Foster , Jordan Rodu , Lyle H. Ungar

This paper introduces a novel methodology that combines the multi-resolution feature of the Gabor wavelet transformation (GWT) with the local interactions of the facial structures expressed through the Pseudo Hidden Markov model (PHMM).…

Computer Vision and Pattern Recognition · Computer Science 2013-12-09 Arindam Kar , Debotosh Bhattacharjee , Dipak Kumar Basu , Mita Nasipuri , Mahantapas Kundu

We present Hecate, a modular lossless genomic compression framework. It is designed around uncommon but practical source-coding choices. Unlike many single-method compressors, Hecate treats compression as a conditional coding problem over…

Data Structures and Algorithms · Computer Science 2026-03-17 Kamila Szewczyk , Sven Rahmann

In this paper we describe our submission to the Zerospeech 2020 challenge, where the participants are required to discover latent representations from unannotated speech, and to use those representations to perform speech synthesis, with…

Audio and Speech Processing · Electrical Eng. & Systems 2020-07-28 Bolaji Yusuf , Lucas Ondel

RNA secondary structure is modeled with the novel arbitrary-order hidden Markov model ({\alpha}-HMM). The {\alpha}-HMM extends over the traditional HMM with capability to model stochastic events that may be in influenced by historically…

Biomolecules · Quantitative Biology 2024-01-09 Sixiang Zhang , Aaron J. Yang , Liming Cai

We introduce PyHHMM, an object-oriented open-source Python implementation of Heterogeneous-Hidden Markov Models (HHMMs). In addition to HMM's basic core functionalities, such as different initialization algorithms and classical observations…

Mathematical Software · Computer Science 2022-01-19 Fernando Moreno-Pino , Emese Sükei , Pablo M. Olmos , Antonio Artés-Rodríguez
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