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This work describes a novel simulation approach that combines machine learning and device modelling simulations. The device simulations are based on the quantum mechanical non-equilibrium Greens function (NEGF) approach and the machine…

Computational Engineering, Finance, and Science · Computer Science 2023-09-19 Preslav Aleksandrov , Ali Rezaei , Nikolas Xeni , Tapas Dutta , Asen Asenov , Vihar Georgiev

Systems governed by partial differential equations (PDEs) require computationally intensive numerical solvers to predict spatiotemporal field evolution. While machine learning (ML) surrogates offer faster solutions, autoregressive inference…

Machine Learning · Computer Science 2025-07-08 Ishan Khurjekar , Indrashish Saha , Lori Graham-Brady , Somdatta Goswami

We propose parameter optimization techniques for weighted ensemble sampling of Markov chains in the steady-state regime. Weighted ensemble consists of replicas of a Markov chain, each carrying a weight, that are periodically resampled…

Numerical Analysis · Mathematics 2022-04-22 David Aristoff , Daniel M. Zuckerman

This paper is concerned with high moment and pathwise error estimates for both velocity and pressure approximations of the Euler-Maruyama scheme for time discretization and its two fully discrete mixed finite element discretizations. The…

Numerical Analysis · Mathematics 2021-07-01 Liet Vo

Non-concave maximization has been the subject of much recent study in the optimization and machine learning communities, specifically in deep learning. Recent papers Ge et al, Lee et al (and references therein) indicate that first order…

Optimization and Control · Mathematics 2020-01-14 Ioannis Panageas , Georgios Piliouras , Xiao Wang

Matching-based methods, especially those based on space-time memory, are significantly ahead of other solutions in semi-supervised video object segmentation (VOS). However, continuously growing and redundant template features lead to an…

Computer Vision and Pattern Recognition · Computer Science 2022-08-23 Zhihui Lin , Tianyu Yang , Maomao Li , Ziyu Wang , Chun Yuan , Wenhao Jiang , Wei Liu

We consider numerical schemes for computing the linear response of steady-state averages of stochastic dynamics with respect to a perturbation of the drift part of the stochastic differential equation. The schemes are based on Girsanov's…

Numerical Analysis · Mathematics 2019-12-18 Petr Plechac , Gabriel Stoltz , Ting Wang

Molecular dynamics simulates the~movements of atoms. Due to its high cost, many methods have been developed to "push the~simulation forward". One of them, metadynamics, can hasten the~molecular dynamics with the~help of variables describing…

Computational Engineering, Finance, and Science · Computer Science 2018-01-09 Jana Pazúriková , Jaroslav Oľha , Aleš Křenek , Vojtěch Spiwok

The approximation of invariant measures for nonlinear ergodic stochastic differential equations (SDEs) is a central problem in scientific computing, with important applications in stochastic sampling, physics, and ecology. We first propose…

Numerical Analysis · Mathematics 2025-11-18 Shan Huang , Xiaoyue Li

The dynamics of molecules are governed by rare event transitions between long-lived (metastable) states. To explore these transitions efficiently, many enhanced sampling protocols have been introduced that involve using simulations with…

Chemical Physics · Physics 2022-09-30 Maaike M. Galama , Hao Wu , Andreas Krämer , Mohsen Sadeghi , Frank Noé

The simulation of complex stochastic network dynamics arising, for instance, from models of coupled biomolecular processes remains computationally challenging. Often, the necessity to scan a models' dynamics over a large parameter space…

Quantitative Methods · Quantitative Biology 2013-03-14 Tiago Ramalho , Marco Selig , Ulrich Gerland , Torsten A. Enßlin

Molecular motors and other complex nonequilibrium systems are controlled by large sets of design parameters, and optimizing those parameters requires computing sensitivities -- derivatives of dynamical observables with respect to the…

Statistical Mechanics · Physics 2026-05-12 John Strahan , Todd R. Gingrich

We introduce Ensemble Rejection Sampling, a scheme for exact simulation from the posterior distribution of the latent states of a class of non-linear non-Gaussian state-space models. Ensemble Rejection Sampling relies on a proposal for the…

Computation · Statistics 2020-01-28 George Deligiannidis , Arnaud Doucet , Sylvain Rubenthaler

The data torrent unleashed by current and upcoming astronomical surveys demands scalable analysis methods. Many machine learning approaches scale well, but separating the instrument measurement from the physical effects of interest, dealing…

Computation · Statistics 2023-04-19 Johannes Buchner

Merging models becomes a fundamental procedure in some applications that consider model efficiency and robustness. The training randomness or Non-I.I.D. data poses a huge challenge for averaging-based model fusion. Previous research efforts…

Artificial Intelligence · Computer Science 2024-08-23 Yichu Xu , Xin-Chun Li , Le Gan , De-Chuan Zhan

Molecular dynamics (MD) simulations are useful in obtaining thermodynamic and kinetic properties of bio-molecules but are limited by the timescale barrier, i.e., we may be unable to efficiently obtain properties because we need to run…

Chemical Physics · Physics 2017-08-23 Surl-Hee Ahn , Jay W. Grate , Eric F. Darve

We presented an efficient algorithm, fast adaptive flat-histogram ensemble (FAFE), to estimate the density of states (DOS) and to enhance sampling in large systems. FAFE calculates the means of an arbitrary extensive variable $U$ in…

Statistical Mechanics · Physics 2008-11-13 Xin Zhou , Yi Jiang

Many recently introduced enhanced sampling techniques are based on biasing coarse descriptors (collective variables) of a molecular system on the fly. Sometimes the calculation of such collective variables is expensive and becomes a…

Computational Physics · Physics 2015-09-01 Marco Jacopo Ferrarotti , Sandro Bottaro , Andrea Pérez-Villa , Giovanni Bussi

Most natural and engineered information-processing systems transmit information via signals that vary in time. Computing the information transmission rate or the information encoded in the temporal characteristics of these signals, requires…

Molecular Networks · Quantitative Biology 2023-10-27 Manuel Reinhardt , Gašper Tkačik , Pieter Rein ten Wolde

Accurate prediction of energy and forces for 3D molecular systems is one of fundamental challenges at the core of AI for Science applications. Many powerful and data-efficient neural networks predict molecular energies and forces from…

Chemical Physics · Physics 2026-04-23 Ali Mollahosseini , Mohammed Haroon Dupty , Wee Sun Lee