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Tissue biopsy evaluation in the clinic is in need of quantitative disease markers for diagnosis and, most importantly, prognosis. Among the new technologies, quantitative phase imaging (QPI) has demonstrated promise for histopathology…

Blood cell identification is critical for hematological analysis as it aids physicians in diagnosing various blood-related diseases. In real-world scenarios, blood cell image datasets often present the issues of domain shift and data…

Computer Vision and Pattern Recognition · Computer Science 2024-12-05 Yongcheng Li , Lingcong Cai , Ying Lu , Xianghua Fu , Xiao Han , Ma Li , Wenxing Lai , Xiangzhong Zhang , Xiaomao Fan

High-fidelity registration of histopathological whole slide images (WSIs), such as hematoxylin & eosin (H&E) and immunohistochemistry (IHC), is vital for integrated molecular analysis but challenging to evaluate without ground-truth (GT)…

Computer Vision and Pattern Recognition · Computer Science 2026-02-05 Shikha Dubey , Patricia Raciti , Kristopher Standish , Albert Juan Ramon , Erik Ames Burlingame

We propose a novel certified defense method for Image Quality Assessment (IQA) models based on randomized smoothing with noise applied in the feature space rather than the input space. Unlike prior approaches that inject Gaussian noise…

Computer Vision and Pattern Recognition · Computer Science 2025-08-08 Ekaterina Shumitskaya , Dmitriy Vatolin , Anastasia Antsiferova

Purpose: In digital histopathology, virtual multi-staining is important for diagnosis and biomarker research. Additionally, it provides accurate ground-truth for various deep-learning tasks. Virtual multi-staining can be obtained using…

Image and Video Processing · Electrical Eng. & Systems 2023-12-15 Johannes Lotz , Nick Weiss , Jeroen van der Laak , Stefan Heldmann

With the rapid advancement of Vision Language Models (VLMs), VLM-based Image Quality Assessment (IQA) seeks to describe image quality linguistically to align with human expression and capture the multifaceted nature of IQA tasks. However,…

Computer Vision and Pattern Recognition · Computer Science 2025-12-01 Zhiyuan You , Jinjin Gu , Xin Cai , Zheyuan Li , Kaiwen Zhu , Chao Dong , Tianfan Xue

Three-dimensional (3D) histopathology of unprocessed tissues has the potential to transform disease management by enabling volumetric characterization of tissue microarchitecture and in-vivo assessment. Back-illumination Interference…

Computer Vision and Pattern Recognition · Computer Science 2026-05-22 Anthony Song , Boyan Zhou , Mayank Golhar , Marisa Morakis , Alex Baras , Nicholas Durr

This paper introduces a Virtual Immunohistochemistry Multiplex staining (VIMs) model designed to generate multiple immunohistochemistry (IHC) stains from a single hematoxylin and eosin (H&E) stained tissue section. IHC stains are crucial in…

Image and Video Processing · Electrical Eng. & Systems 2024-07-30 Shikha Dubey , Yosep Chong , Beatrice Knudsen , Shireen Y. Elhabian

Reliable whole slide imaging (WSI) hinges on image quality,yet staining artefacts, defocus, and cellular degradations are common. We present DPC-QA Net, a no-reference dual-stream network that couples wavelet-based global difference…

Image and Video Processing · Electrical Eng. & Systems 2025-09-22 Qijun Yang , Boyang Wang , Hujun Yin

This paper introduces KnowHalu, a novel approach for detecting hallucinations in text generated by large language models (LLMs), utilizing step-wise reasoning, multi-formulation query, multi-form knowledge for factual checking, and…

Computation and Language · Computer Science 2024-04-05 Jiawei Zhang , Chejian Xu , Yu Gai , Freddy Lecue , Dawn Song , Bo Li

Artificial intelligence (AI) has shown great promise for diagnostic imaging assessments. However, the application of AI to support medical diagnostics in clinical routine comes with many challenges. The algorithms should have high…

Computer Vision and Pattern Recognition · Computer Science 2020-08-17 Milda Pocevičiūtė , Gabriel Eilertsen , Claes Lundström

Automatic perception of image quality is a challenging problem that impacts billions of Internet and social media users daily. To advance research in this field, we propose a no-reference image quality assessment (NR-IQA) method termed…

Computer Vision and Pattern Recognition · Computer Science 2024-05-08 Zhen Zhang

The rapid development of text-to-image (T2I) generation approaches has attracted extensive interest in evaluating the quality of generated images, leading to the development of various quality assessment methods for general-purpose T2I…

Computer Vision and Pattern Recognition · Computer Science 2025-05-01 Yunhao Li , Sijing Wu , Wei Sun , Zhichao Zhang , Yucheng Zhu , Zicheng Zhang , Huiyu Duan , Xiongkuo Min , Guangtao Zhai

Traditional image quality assessment (IQA) methods rely on mean opinion scores (MOS), which are resource-intensive to collect and fail to provide interpretable, localized feedback on specific image distortions. We overcome these limitations…

Computer Vision and Pattern Recognition · Computer Science 2026-05-05 Fadeel Sher Khan , Long N. Le , Abhinau K. Venkataramanan , Seok-Jun Lee , Hamid R. Sheikh

Current full-reference image quality assessment (FR-IQA) methods often fuse features from reference and distorted images, overlooking that color and luminance distortions occur mainly at low frequencies, whereas edge and texture distortions…

Image and Video Processing · Electrical Eng. & Systems 2024-12-23 Xuekai Wei , Junyu Zhang , Qinlin Hu , Mingliang Zhou\\Yong Feng , Weizhi Xian , Huayan Pu , Sam Kwong

Histological images are obtained by transmitting light through a tissue specimen that has been stained in order to produce contrast. This process results in 2D images of the specimen that has a three-dimensional structure. In this paper, we…

Computer Vision and Pattern Recognition · Computer Science 2018-01-11 Maxime W. Lafarge , Josien P. W. Pluim , Koen A. J. Eppenhof , Pim Moeskops , Mitko Veta

Rheumatoid Arthritis (RA) is a chronic, autoimmune disease which primarily affects the joint's synovial tissue. It is a highly heterogeneous disease, with wide cellular and molecular variability observed in synovial tissues. Over the last…

Image and Video Processing · Electrical Eng. & Systems 2023-09-15 Amaya Gallagher-Syed , Abbas Khan , Felice Rivellese , Costantino Pitzalis , Myles J. Lewis , Gregory Slabaugh , Michael R. Barnes

Histological whole slide images (WSIs) can be usually compromised by artifacts, such as tissue folding and bubbles, which will increase the examination difficulty for both pathologists and Computer-Aided Diagnosis (CAD) systems. Existing…

Image and Video Processing · Electrical Eng. & Systems 2023-07-27 Zhenqi He , Junjun He , Jin Ye , Yiqing Shen

Video Instance Segmentation (VIS) faces significant annotation challenges due to its dual requirements of pixel-level masks and temporal consistency labels. While recent unsupervised methods like VideoCutLER eliminate optical flow…

Computer Vision and Pattern Recognition · Computer Science 2025-08-28 Kaixuan Lu , Mehmet Onurcan Kaya , Dim P. Papadopoulos

One of the challenges facing the adoption of digital pathology workflows for clinical use is the need for automated quality control. As the scanners sometimes determine focus inaccurately, the resultant image blur deteriorates the scanned…

Image and Video Processing · Electrical Eng. & Systems 2018-11-16 Mahdi S. Hosseini , Yueyang Zhang , Lyndon Chan , Konstantinos N. Plataniotis , Jasper A. Z. Brawley-Hayes , Savvas Damaskinos