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This paper presents a new method for modeling the mechanics of the aortic valve, and simulates its interaction with blood. As much as possible, the model construction is based on first principles, but such that the model is consistent with…

Tissues and Organs · Quantitative Biology 2021-10-15 Alexander D. Kaiser , Rohan Shad , William Hiesinger , Alison L. Marsden

Over the past few decades, there has been a rapid improvement in computational power as well as techniques to simulate the real world phenomenon which has enabled us to understand the physics and develop new systems which outperform the…

Computational Physics · Physics 2020-06-09 Sumant R Morab , Atul Sharma

Systematic in vivo validations of computational models of the aortic valve remain scarce, despite successful validation against in vitro data. Utilizing a combination of computed tomography and 4D flow magnetic resonance imaging data, we…

The zebrafish is a valuable model organism for studying cardiac development and diseases due to its many shared aspects of genetics and anatomy with humans and ease of experimental manipulations. Computational fluid-structure interaction…

Tissues and Organs · Quantitative Biology 2025-06-23 Alexander D. Kaiser , Jing Wang , Aaron L. Brown , Enbo Zhu , Tzung Hsiai , Alison L. Marsden

The efficient and voidless filling of microcavities is of great importance for Lab-on-a-Chip applications. However, predicting whether microcavities will be filled or not under different circumstances is still difficult due to the local…

Fluid Dynamics · Physics 2025-04-02 Luise Nagel , Anja Lippert , Ronny Leonhardt , Tobias Tolle , Huijie Zhang , Tomislav Maric

Cardiac fluid dynamics fundamentally involves interactions between complex blood flows and the structural deformations of the muscular heart walls and the thin, flexible valve leaflets. There has been longstanding scientific, engineering,…

We present a new model and a novel loosely coupled partitioned numerical scheme modeling fluid-structure interaction (FSI) in blood flow allowing non-zero longitudinal displacement. Arterial walls are modeled by a {linearly viscoelastic,…

Numerical Analysis · Mathematics 2015-06-05 Martina Bukac , Suncica Canic , Roland Glowinski , Josip Tambaca , Annalisa Quaini

Computational fluid dynamics is intensively used to deepen the understanding of aneurysm growth and rupture in the attempt to support physicians during therapy planning. Numerous studies have assumed fully-rigid vessel walls in their…

Fluid Dynamics · Physics 2023-08-17 Aurèle Goetz , Pablo Jeken Rico , Yves Chau , Jacques Sédat , Aurélien Larcher , Elie Hachem

Simulation approaches for fluid-structure-contact interaction, especially if requested to be consistent even down to the real contact scenarios, belong to the most challenging and still unsolved problems in computational mechanics. The main…

Computational Engineering, Finance, and Science · Computer Science 2018-09-12 Christoph Ager , Benedikt Schott , Anh-Tu Vuong , Alexander Popp , Wolfgang A. Wall

Fluid-Structure Interaction (FSI) can be investigated by means of non-linear Finite Element Models (FEM), suitable to capture large deflections of structural parts interacting with fluids, and Computational Fluid Dynamics (CFD). High…

We used volume-of-fluid (VOF) method to perform three-dimensional numerical simulations of droplet formation of Newtonian fluids in microfluidic T-junction devices. To evaluate the performance of the VOF method we examined the regimes of…

Fluid Dynamics · Physics 2017-04-26 Mehdi Nekouei , Siva A. Vanapalli

Understanding the interaction between the valves and walls of the heart is important in assessing and subsequently treating heart dysfunction. With advancements in cardiac imaging, nonlinear mechanics and computational techniques, it is now…

Medical Physics · Physics 2017-04-07 Hao Gao , Liuyang Feng , Nan Qi , Colin Berry , Boyce Griffith , Xiaoyu Luo

In this article, we have developed a computational model to determine the droplet formation regime and its transition in a square microfluidic flow-focusing device that eventually dictate the droplet shape, size, and its formation…

Fluid Dynamics · Physics 2025-10-28 Somasekhara Goud Sontti , Arnab Atta

Microfluidic valves play a key role within microfluidic systems by regulating fluid flow through distinct microchannels, enabling many advanced applications in medical diagnostics, lab-on-chips, and laboratory automation. While microfluidic…

Materials Science · Physics 2023-12-19 Tinku Supakar , David Space , Sophy Meija , Rou Yu Tan , Jeffrey R. Alston , Eric A. Josephs

To study the dynamics of particles in turbulence when their sizes are comparable to the smallest eddies in the flow, the Kolmogorov length scale, efficient and accurate numerical models for the particle-fluid interaction are still missing.…

Fluid Dynamics · Physics 2018-02-28 Toshiaki Fukada , Walter Fornari , Luca Brandt , Shintaro Takeuchi , Takeo Kajishima

A microfluidic device is constructed from PDMS with a single channel having a short section that is a thin flexible membrane, in order to investigate the complex fluid-structure interaction that arises between a flowing fluid and a…

Soft Condensed Matter · Physics 2020-07-03 Debadi Chakraborty , J. Ravi Prakash , Leslie Yeo , James Friend

We evaluate a number of different finite element approaches for fluid-structure (contact) interaction problems against data from physical experiments. For this we take the data from experiments by Hagemeier [Mendeley Data, doi:…

Fluid Dynamics · Physics 2021-03-03 Henry von Wahl , Thomas Richter , Stefan Frei , Thomas Hagemeier

We present an adaptive reduced-order model for the efficient time-resolved simulation of fluid-structure interaction problems with complex and non-linear deformations. The model is based on repeated linearizations of the structural balance…

Fluid Dynamics · Physics 2020-04-13 Ali Thari , Vito Pasquariello , Niels Aage , Stefan Hickel

An interface control principle is proposed for unsteady fluid-structure in- teraction (FSI) analyses. This principle introduces a method of explicitly controlling the interface motion in the temporal direction to minimize the residual force…

Fluid Dynamics · Physics 2025-10-21 Chungil Lee , Yoshiaki Abe , Yu Kawano , Tomoki Yamazaki

We present a computational framework to address the flow of two immiscible viscous liquids which co-flow into a shallow rectangular container at one side, and flow out into a holding container at the opposite side. Assumptions based on the…

Fluid Dynamics · Physics 2013-09-02 Shahriar Afkhami , Yuriko Renardy
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