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The field of health informatics has been profoundly influenced by the development of random forest models, which have led to significant advances in the interpretability of feature interactions. These models are characterized by their…

Machine Learning · Computer Science 2025-06-04 Akshat Dubey , Aleksandar Anžel , Georges Hattab

State-of-the-art clustering algorithms use heuristics to partition the feature space and provide little insight into the rationale for cluster membership, limiting their interpretability. In healthcare applications, the latter poses a…

Machine Learning · Statistics 2018-12-04 Dimitris Bertsimas , Agni Orfanoudaki , Holly Wiberg

This paper explores interpretability techniques for two of the most successful learning algorithms in medical decision-making literature: deep neural networks and random forests. We applied these algorithms in a real-world medical dataset…

Machine Learning · Computer Science 2020-02-24 Catarina Moreira , Renuka Sindhgatta , Chun Ouyang , Peter Bruza , Andreas Wichert

Machine learning algorithms often assume that training samples are independent. When data points are connected by a network, the induced dependency between samples is both a challenge, reducing effective sample size, and an opportunity to…

Machine Learning · Statistics 2025-09-22 Tiffany M. Tang , Elizaveta Levina , Ji Zhu

It is becoming increasingly important for machine learning methods to make predictions that are interpretable as well as accurate. In many practical applications, it is of interest which features and feature interactions are relevant to the…

Machine Learning · Statistics 2016-02-09 Viktoriya Krakovna , Jiong Du , Jun S. Liu

Nowadays new technologies, and especially artificial intelligence, are more and more established in our society. Big data analysis and machine learning, two sub-fields of artificial intelligence, are at the core of many recent breakthroughs…

Machine Learning · Statistics 2021-06-22 Antonio Sutera

Fair clustering has gained increasing attention in recent years, especially in applications involving socially sensitive attributes. However, existing fair clustering methods often lack interpretability, limiting their applicability in…

Machine Learning · Computer Science 2025-11-27 Mudi Jiang , Jiahui Zhou , Xinying Liu , Zengyou He , Zhikui Chen

In domains where transparency and trustworthiness are crucial, such as healthcare, rule-based systems are widely used and often preferred over black-box models for decision support systems due to their inherent interpretability. However, as…

Machine Learning · Computer Science 2025-06-18 Christel Sirocchi , Damiano Verda

Random forests (RFs) are among the most popular supervised learning algorithms due to their nonlinear flexibility and ease-of-use. However, as black box models, they can only be interpreted via algorithmically-defined feature importance…

Methodology · Statistics 2025-05-26 Abhineet Agarwal , Ana M. Kenney , Yan Shuo Tan , Tiffany M. Tang , Bin Yu

In the realm of precision medicine, effective patient stratification and disease subtyping demand innovative methodologies tailored for multi-omics data. Clustering techniques applied to multi-omics data have become instrumental in…

Machine Learning · Computer Science 2024-01-30 Bastian Pfeifer , Christel Sirocchi , Marcus D. Bloice , Markus Kreuzthaler , Martin Urschler

Interpretability has become incredibly important as machine learning is increasingly used to inform consequential decisions. We propose to construct global explanations of complex, blackbox models in the form of a decision tree…

Machine Learning · Computer Science 2019-01-28 Osbert Bastani , Carolyn Kim , Hamsa Bastani

As machine learning models are increasingly deployed in sensitive application areas, the demand for interpretable and trustworthy decision-making has increased. Random Forests (RF), despite their widespread use and strong performance on…

Anomaly Detection is an unsupervised learning task aimed at detecting anomalous behaviours with respect to historical data. In particular, multivariate Anomaly Detection has an important role in many applications thanks to the capability of…

Machine Learning · Computer Science 2021-07-14 Mattia Carletti , Matteo Terzi , Gian Antonio Susto

Random forests are a machine learning method used to automatically classify datasets and consist of a multitude of decision trees. While these random forests often have higher performance and generalize better than a single decision tree,…

Machine Learning · Computer Science 2025-07-31 Max Sondag , Christofer Meinecke , Dennis Collaris , Tatiana von Landesberger , Stef van den Elzen

Feature selection in Knowledge Graphs (KGs) are increasingly utilized in diverse domains, including biomedical research, Natural Language Processing (NLP), and personalized recommendation systems. This paper delves into the methodologies…

Machine Learning · Computer Science 2024-06-24 Sisi Shao , Pedro Henrique Ribeiro , Christina Ramirez , Jason H. Moore

Functional survival models are key tools for analyzing time-to-event data with complex predictors, such as functional or high-dimensional inputs. Despite their predictive strength, these models often lack interpretability, which limits…

Machine Learning · Statistics 2025-04-28 Giuseppe Loffredo , Elvira Romano , Fabrizio MAturo

Clustering ensemble has emerged as an important research topic in the field of machine learning. Although numerous methods have been proposed to improve clustering quality, most existing approaches overlook the need for interpretability in…

Machine Learning · Computer Science 2025-06-09 Hang Lv , Lianyu Hu , Mudi Jiang , Xinying Liu , Zengyou He

Decision-making in complex systems often relies on machine learning models, yet highly accurate models such as XGBoost and neural networks can obscure the reasoning behind their predictions. In operations research applications,…

Machine Learning · Computer Science 2025-02-28 Gaurav Arwade , Sigurdur Olafsson

The analysis of DNA sequences has become critical in numerous fields, from evolutionary biology to understanding gene regulation and disease mechanisms. While deep neural networks can achieve remarkable predictive performance, they…

Machine Learning · Computer Science 2026-04-15 Nicolas Huynh , Krzysztof Kacprzyk , Ryan Sheridan , David Bentley , Mihaela van der Schaar

Deep forest is a non-differentiable deep model which has achieved impressive empirical success across a wide variety of applications, especially on categorical/symbolic or mixed modeling tasks. Many of the application fields prefer…

Machine Learning · Computer Science 2023-05-02 Yi-Xiao He , Shen-Huan Lyu , Yuan Jiang
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