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Large language models have proliferated across multiple domains in as short period of time. There is however hesitation in the medical and healthcare domain towards their adoption because of issues like factuality, coherence, and…

Computation and Language · Computer Science 2023-11-06 Muhammad Aurangzeb Ahmad , Ilker Yaramis , Taposh Dutta Roy

The deployment of large language models (LLMs) in healthcare has demonstrated substantial potential for enhancing clinical decision-making, administrative efficiency, and patient outcomes. However, the underrepresentation of diverse groups…

The integration of Large Language Models (LLMs) into the drug discovery and development field marks a significant paradigm shift, offering novel methodologies for understanding disease mechanisms, facilitating drug discovery, and optimizing…

Quantitative Methods · Quantitative Biology 2024-09-10 Yizhen Zheng , Huan Yee Koh , Maddie Yang , Li Li , Lauren T. May , Geoffrey I. Webb , Shirui Pan , George Church

In recent years, the integration of Large Language Models (LLMs) into recommender systems has garnered interest among both practitioners and researchers. Despite this interest, the field is still emerging, and the lack of open-source R&D…

Information Retrieval · Computer Science 2024-04-12 Shuyuan Xu , Wenyue Hua , Yongfeng Zhang

The rapid advancement of large language models (LLMs) has opened new boundaries in the extraction and synthesis of medical knowledge, particularly within evidence synthesis. This paper reviews the state-of-the-art applications of LLMs in…

The applications of large language models (LLMs) are promising for biomedical and healthcare research. Despite the availability of open-source LLMs trained using a wide range of biomedical data, current research on the applications of LLMs…

Machine Learning · Computer Science 2024-09-25 Tianyu Liu , Yijia Xiao , Xiao Luo , Hua Xu , W. Jim Zheng , Hongyu Zhao

Automatic disease diagnosis has become increasingly valuable in clinical practice. The advent of large language models (LLMs) has catalyzed a paradigm shift in artificial intelligence, with growing evidence supporting the efficacy of LLMs…

We present Apertus, a fully open suite of large language models (LLMs) designed to address two systemic shortcomings in today's open model ecosystem: data compliance and multilingual representation. Unlike many prior models that release…

Computation and Language · Computer Science 2025-12-03 Project Apertus , Alejandro Hernández-Cano , Alexander Hägele , Allen Hao Huang , Angelika Romanou , Antoni-Joan Solergibert , Barna Pasztor , Bettina Messmer , Dhia Garbaya , Eduard Frank Ďurech , Ido Hakimi , Juan García Giraldo , Mete Ismayilzada , Negar Foroutan , Skander Moalla , Tiancheng Chen , Vinko Sabolčec , Yixuan Xu , Michael Aerni , Badr AlKhamissi , Inés Altemir Mariñas , Mohammad Hossein Amani , Matin Ansaripour , Ilia Badanin , Harold Benoit , Emanuela Boros , Nicholas Browning , Fabian Bösch , Maximilian Böther , Niklas Canova , Camille Challier , Clement Charmillot , Jonathan Coles , Jan Deriu , Arnout Devos , Lukas Drescher , Daniil Dzenhaliou , Maud Ehrmann , Dongyang Fan , Simin Fan , Silin Gao , Miguel Gila , María Grandury , Diba Hashemi , Alexander Hoyle , Jiaming Jiang , Mark Klein , Andrei Kucharavy , Anastasiia Kucherenko , Frederike Lübeck , Roman Machacek , Theofilos Manitaras , Andreas Marfurt , Kyle Matoba , Simon Matrenok , Henrique Mendonça , Fawzi Roberto Mohamed , Syrielle Montariol , Luca Mouchel , Sven Najem-Meyer , Jingwei Ni , Gennaro Oliva , Matteo Pagliardini , Elia Palme , Andrei Panferov , Léo Paoletti , Marco Passerini , Ivan Pavlov , Auguste Poiroux , Kaustubh Ponkshe , Nathan Ranchin , Javi Rando , Mathieu Sauser , Jakhongir Saydaliev , Muhammad Ali Sayfiddinov , Marian Schneider , Stefano Schuppli , Marco Scialanga , Andrei Semenov , Kumar Shridhar , Raghav Singhal , Anna Sotnikova , Alexander Sternfeld , Ayush Kumar Tarun , Paul Teiletche , Jannis Vamvas , Xiaozhe Yao , Hao Zhao , Alexander Ilic , Ana Klimovic , Andreas Krause , Caglar Gulcehre , David Rosenthal , Elliott Ash , Florian Tramèr , Joost VandeVondele , Livio Veraldi , Martin Rajman , Thomas Schulthess , Torsten Hoefler , Antoine Bosselut , Martin Jaggi , Imanol Schlag

Large Language Models (LLMs) are transforming healthcare through the development of LLM-based agents that can understand, reason about, and assist with medical tasks. This survey provides a comprehensive review of LLM-based agents in…

Computation and Language · Computer Science 2025-05-27 Wenxuan Wang , Zizhan Ma , Zheng Wang , Chenghan Wu , Jiaming Ji , Wenting Chen , Xiang Li , Yixuan Yuan

Artificial intelligence (AI) has gained significant attention in healthcare consultation due to its potential to improve clinical workflow and enhance medical communication. However, owing to the complex nature of medical information, large…

Computation and Language · Computer Science 2024-03-05 Xiaolan Chen , Ziwei Zhao , Weiyi Zhang , Pusheng Xu , Le Gao , Mingpu Xu , Yue Wu , Yinwen Li , Danli Shi , Mingguang He

In the fast-evolving domain of artificial intelligence, large language models (LLMs) such as GPT-3 and GPT-4 are revolutionizing the landscapes of finance, healthcare, and law: domains characterized by their reliance on professional…

Computation and Language · Computer Science 2024-11-25 Zhiyu Zoey Chen , Jing Ma , Xinlu Zhang , Nan Hao , An Yan , Armineh Nourbakhsh , Xianjun Yang , Julian McAuley , Linda Petzold , William Yang Wang

Upon its release in late 2022, ChatGPT has brought a seismic shift in the entire landscape of AI, both in research and commerce. Through instruction-tuning a large language model (LLM) with supervised fine-tuning and reinforcement learning…

Computation and Language · Computer Science 2024-01-17 Hailin Chen , Fangkai Jiao , Xingxuan Li , Chengwei Qin , Mathieu Ravaut , Ruochen Zhao , Caiming Xiong , Shafiq Joty

Clinical summarization is crucial in healthcare as it distills complex medical data into digestible information, enhancing patient understanding and care management. Large language models (LLMs) have shown significant potential in…

Computation and Language · Computer Science 2025-08-21 Anindya Bijoy Das , Shibbir Ahmed , Shahnewaz Karim Sakib

The adoption of large language models (LLMs) to assist clinicians has attracted remarkable attention. Existing works mainly adopt the close-ended question-answering (QA) task with answer options for evaluation. However, many clinical…

The rise of large language models (LLMs) has transformed healthcare by offering clinical guidance, yet their direct deployment to patients poses safety risks due to limited domain expertise. To mitigate this, we propose repositioning LLMs…

Computation and Language · Computer Science 2025-10-14 Wenya Xie , Qingying Xiao , Yu Zheng , Xidong Wang , Junying Chen , Ke Ji , Anningzhe Gao , Prayag Tiwari , Xiang Wan , Feng Jiang , Benyou Wang

Large Language Models (LLMs) are transforming AI across industries, but their development and deployment remain complex. This survey reviews 16 key challenges in building and using LLMs and examines how these challenges are addressed by two…

Computation and Language · Computer Science 2025-09-01 Shubham Sharma , Sneha Tuli , Narendra Badam

Large language models (LLMs) have attracted significant attention for potential applications in digital health, while their application in mental health is subject to ongoing debate. This systematic review aims to evaluate the usage of LLMs…

Computers and Society · Computer Science 2024-08-14 Zhijun Guo , Alvina Lai , Johan Hilge Thygesen , Joseph Farrington , Thomas Keen , Kezhi Li

Objective: Large language models (LLMs) are attracting increasing interest in healthcare. This commentary evaluates the potential of LLMs to improve clinical prediction models (CPMs) for diagnostic and prognostic tasks, with a focus on…

Computers and Society · Computer Science 2025-11-07 Yusuf Yildiz , Goran Nenadic , Meghna Jani , David A. Jenkins

The implementation of Artificial Intelligence (AI) in the healthcare industry has garnered considerable attention, attributable to its prospective enhancement of clinical outcomes, expansion of access to superior healthcare, cost reduction,…

Computation and Language · Computer Science 2024-08-23 Arindam Sett , Somaye Hashemifar , Mrunal Yadav , Yogesh Pandit , Mohsen Hejrati

This paper conducts a comprehensive investigation into applying large language models, particularly on BioBERT, in healthcare. It begins with thoroughly examining previous natural language processing (NLP) approaches in healthcare, shedding…

Artificial Intelligence · Computer Science 2023-10-13 Shyni Sharaf , V. S. Anoop
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