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Quantum mechanics has introduced a new theoretical framework for the study of molecules, enabling the prediction of properties and dynamics through the solution of the Schr\"odinger equation applied to these systems. However, solving this…

An accurate assessment of how quantum computers can be used for chemical simulation, especially their potential computational advantages, provides important context on how to deploy these future devices. In order to perform this assessment…

Quantum computing offers the promise of revolutionizing quantum chemistry by enabling the solution of chemical problems for substantially less computational cost. While most demonstrations of quantum computation to date have focused on…

Chemical Physics · Physics 2026-05-13 Alan Bidart , Prateek Vaish , Tilas Kabengele , Yaoqi Pang , Yuan Liu , Brenda M. Rubenstein

Quantum computing leverages the quantum resources of superposition and entanglement to efficiently solve computational problems considered intractable for classical computers. Examples include calculating molecular and nuclear structure,…

Simulating chemical systems is highly sought after and computationally challenging, as the number of degrees of freedom increases exponentially with the size of the system. Quantum computers have been proposed as a computational means to…

The emerging field of quantum resource estimation is aimed at providing estimates of the hardware requirements (`quantum resources') needed to execute a useful, fault-tolerant quantum computation. Given that quantum computers are intended…

Quantum Physics · Physics 2025-06-06 Alan Robertson , Haowen Gao , Yuval R. Sanders

The simulation of molecules is a widely anticipated application of quantum computers. However, recent studies \cite{WBCH13a,HWBT14a} have cast a shadow on this hope by revealing that the complexity in gate count of such simulations…

Quantum Physics · Physics 2015-10-05 David Poulin , M. B. Hastings , Dave Wecker , Nathan Wiebe , Andrew C. Doherty , Matthias Troyer

Digital quantum computers promise exponential speedups in performing quantum time-evolution, providing an opportunity to simulate quantum dynamics of complex systems in physics and chemistry. However, the task of extracting desired quantum…

Quantum Physics · Physics 2025-03-10 Chong Hian Chee , Daniel Leykam , Adrian M. Mak , Kishor Bharti , Dimitris G. Angelakis

Quantum error detection (QED) offers a promising pathway to fault tolerance in near-term quantum devices by balancing error suppression with minimal resource overhead. However, its practical utility hinges on optimizing design…

Quantum Physics · Physics 2025-04-14 Tom Ginsberg , Vyom Patel

Quantum computing promises disruptive capabilities, yet its energy footprint has received far less attention than its asymptotic speedups. We present a first-order, full-system energy model for quantum computing in an high performance…

Quantum Physics · Physics 2026-05-13 Siyuan Niu , Di Wu , Ozgur Ozan Kilic , Kwangmin Yu

Quantum computers have the potential to be a profoundly transformative technology, particularly in the context of quantum chemistry. However, running a chemistry application that is demonstrably useful currently requires a prohibitive…

Quantum Physics · Physics 2020-04-13 Sam Pallister

We present the first demonstration of an end-to-end pipeline with quantum error correction (QEC) for a quantum computation of the electronic structure of molecular systems. We calculate the ground-state energy of molecular hydrogen, using…

Quantum Chemistry (QC) is one of the most promising applications of Quantum Computing. However, present quantum processing units (QPUs) are still subject to large errors. Therefore, noisy intermediate-scale quantum (NISQ) hardware is…

Quantum Physics · Physics 2025-10-21 Mohammad Haidar , Marko J. Rančić , Thomas Ayral , Yvon Maday , Jean-Philip Piquemal

Quantum computing offers a potential for algorithmic speedups for applications, such as large-scale simulations in chemistry and physics. However, these speedups must yield results that are sufficiently accurate to predict realistic…

Quantum Physics · Physics 2025-01-15 Meenambika Gowrishankar , Daniel Claudino , Jerimiah Wright , Travis Humble

Various benchmarking metrics have been developed to quantify the performance of quantum computing hardware and help evaluate development. However, it is not always necessary to know the metric values precisely. This is especially true for…

Quantum Physics · Physics 2025-02-04 Brandon Rodenburg

Quantum computing offers a new paradigm for advancing high-energy physics research by enabling novel methods for representing and reasoning about fundamental quantum mechanical phenomena. Realizing these ideals will require the development…

Quantum computers theoretically promise computational advantage in many tasks, but it is much less clear how such advantage can be maintained when using existing and near-term hardware that has limitations in the number and quality of its…

Quantum Physics · Physics 2025-03-05 Stuart Ferguson , Petros Wallden

Quantum chemistry simulations that accurately predict the properties of materials are among the most highly anticipated applications of quantum computing. It is widely believed that simulations running on quantum computers will allow for…

Practical challenges in simulating quantum systems on classical computers have been widely recognized in the quantum physics and quantum chemistry communities over the past century. Although many approximation methods have been introduced,…

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