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Multiple sequence alignment (MSA) is a core operation for comparing genome sequences and is widely used in bio-informatics. MAFFT, a practical MSA tool, repeatedly shifts a pair of sequences and computes a distance. Because the number of…

Quantum Physics · Physics 2026-03-02 Yusuke Kimura , Yutaka Takita

Stochastic-gradient-based optimization has been a core enabling methodology in applications to large-scale problems in machine learning and related areas. Despite the progress, the gap between theory and practice remains significant, with…

Optimization and Control · Mathematics 2021-01-01 Lihua Lei , Michael I. Jordan

Variational (or, parameterized) quantum circuits are quantum circuits that contain real-number parameters, that need to be optimized/"trained" in order to achieve the desired quantum-computational effect. For that training, analytic…

Quantum Physics · Physics 2022-04-19 Dirk Oliver Theis

Stochastic approximation (SA) is a key method used in statistical learning. Recently, its non-asymptotic convergence analysis has been considered in many papers. However, most of the prior analyses are made under restrictive assumptions…

Machine Learning · Statistics 2019-06-18 Belhal Karimi , Blazej Miasojedow , Eric Moulines , Hoi-To Wai

Variational Quantum Algorithms (VQAs) are a class of hybrid quantum-classical algorithms that leverage on classical optimization tools to find the optimal parameters for a parameterized quantum circuit. One relevant application of VQAs is…

Quantum Physics · Physics 2026-01-26 Mirko Legnini , Julian Berberich

We propose an online learning algorithm for a class of machine learning models under a separable stochastic approximation framework. The essence of our idea lies in the observation that certain parameters in the models are easier to…

Machine Learning · Computer Science 2023-05-23 Min Gan , Xiang-xiang Su , Guang-yong Chen , Jing Chen

Stochastic Gradient (SG) is the defacto iterative technique to solve stochastic optimization (SO) problems with a smooth (non-convex) objective $f$ and a stochastic first-order oracle. SG's attractiveness is due in part to its simplicity of…

Optimization and Control · Mathematics 2024-03-08 David Newton , Raghu Bollapragada , Raghu Pasupathy , Nung Kwan Yip

We consider an improper reinforcement learning setting where a learner is given $M$ base controllers for an unknown Markov decision process, and wishes to combine them optimally to produce a potentially new controller that can outperform…

Machine Learning · Computer Science 2021-07-06 Mohammadi Zaki , Avinash Mohan , Aditya Gopalan , Shie Mannor

Partial Bayesian neural networks (pBNNs) have been shown to perform competitively with fully Bayesian neural networks while only having a subset of the parameters be stochastic. Using sequential Monte Carlo (SMC) samplers as the inference…

Machine Learning · Computer Science 2026-01-30 Andrew Millard , Joshua Murphy , Simon Maskell , Zheng Zhao

Spiking neural networks (SNNs) represent a promising approach in machine learning, combining the hierarchical learning capabilities of deep neural networks with the energy efficiency of spike-based computations. Traditional end-to-end…

Neural and Evolutionary Computing · Computer Science 2024-11-12 Ruyin Wan , Qian Zhang , George Em Karniadakis

In the present noisy intermediate scale quantum computing era, there is a critical need to devise methods for the efficient implementation of gate-based variational quantum circuits. This ensures that a range of proposed applications can be…

Quantum Physics · Physics 2024-08-27 Ankit Kulshrestha , Xiaoyuan Liu , Hayato Ushijima-Mwesigwa , Bao Bach , Ilya Safro

We consider in this work a system of two stochastic differential equations named the perturbed compositional gradient flow. By introducing a separation of fast and slow scales of the two equations, we show that the limit of the slow motion…

Probability · Mathematics 2018-07-26 Wenqing Hu , Chris Junchi Li

This paper introduces PROMISE ($\textbf{Pr}$econditioned Stochastic $\textbf{O}$ptimization $\textbf{M}$ethods by $\textbf{I}$ncorporating $\textbf{S}$calable Curvature $\textbf{E}$stimates), a suite of sketching-based preconditioned…

Optimization and Control · Mathematics 2024-03-15 Zachary Frangella , Pratik Rathore , Shipu Zhao , Madeleine Udell

Variational Quantum Algorithm (VQA) is a hybrid algorithm for noisy quantum devices. However, statistical fluctuations and physical noise degrade the solution quality, so it is difficult to maintain applicability for large-scale problems.…

Quantum Physics · Physics 2025-04-18 Hiromichi Matsuyama , Yu Yamashiro

The quantum approximate optimization algorithm (QAOA), as a hybrid quantum/classical algorithm, has received much interest recently. QAOA can also be viewed as a variational ansatz for quantum control. However, its direct application to…

Quantum Physics · Physics 2020-05-19 Jiahao Yao , Marin Bukov , Lin Lin

The variational quantum algorithm (VQA) with a parametrized quantum circuit is widely applicable to near-term quantum computing, but its fundamental issues that limit optimization performance have been reported in the literature. For…

We propose a quantum-assisted framework for solving constrained finite-horizon nonlinear optimal control problems using a barrier Sequential Quadratic Programming (SQP) approach. Within this framework, a quantum subroutine is incorporated…

Quantum Physics · Physics 2025-10-22 Nahid Binandeh Dehaghani , Rafal Wisniewski , A. Pedro Aguiar

Parameterized Quantum Circuits (PQC) have obtained increasing popularity thanks to their great potential for near-term Noisy Intermediate-Scale Quantum (NISQ) computers. Achieving quantum advantages usually requires a large number of qubits…

Considering generating samples with high rewards, we focus on optimizing deep neural networks parameterized stochastic differential equations (SDEs), the advanced generative models with high expressiveness, with policy gradient, the leading…

Machine Learning · Computer Science 2024-06-27 Xiangxin Zhou , Liang Wang , Yichi Zhou

In the noisy intermediate-scale quantum era, emerging classical-quantum hybrid optimization algorithms, such as variational quantum algorithms (VQAs), can leverage the unique characteristics of quantum devices to accelerate computations…