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As alternatives to the time-to-first-event analysis of composite endpoints, the {\it net benefit} (NB) and the {\it win ratio} (WR) -- which assess treatment effects using prioritized component outcomes based on clinical importance -- have…

Methodology · Statistics 2020-11-24 Roland A. Matsouaka , Adrian Coles

Evaluating treatment effect heterogeneity widely informs treatment decision making. At the moment, much emphasis is placed on the estimation of the conditional average treatment effect via flexible machine learning algorithms. While these…

Methodology · Statistics 2021-05-07 Lihua Lei , Emmanuel J. Candès

Small sample sizes in clinical studies arises from factors such as reduced costs, limited subject availability, and the rarity of studied conditions. This creates challenges for accurately calculating confidence intervals (CIs) using the…

Methodology · Statistics 2025-11-11 Mulan Wu , Mengyu Xu , Dongyun Kim

Instrumental variable methods are among the most commonly used causal inference approaches to deal with unmeasured confounders in observational studies. The presence of invalid instruments is the primary concern for practical applications,…

Methodology · Statistics 2023-04-18 Zijian Guo

Many inference problems, such as sequential decision problems like A/B testing, adaptive sampling schemes like bandit selection, are often online in nature. The fundamental problem for online inference is to provide a sequence of confidence…

Statistics Theory · Mathematics 2021-06-07 Arun Kumar Kuchibhotla , Qinqing Zheng

We develop new methods for constructing confidence sets and intervals in linear instrumental variables (IV) models based on tests that remain valid under weak identification and under heteroskedastic, autocorrelated, or clustered errors. In…

Econometrics · Economics 2026-04-07 Gustavo Schlemper , Marcelo J. Moreira

Intuitively, unfamiliarity should lead to lack of confidence. In reality, current algorithms often make highly confident yet wrong predictions when faced with relevant but unfamiliar examples. A classifier we trained to recognize gender is…

Computer Vision and Pattern Recognition · Computer Science 2020-09-09 Zhizhong Li , Derek Hoiem

Given a set of aligned sequences of independent noisy observations, we are concerned with detecting intervals where the mean values of the observations change simultaneously in a subset of the sequences. The intervals of changed means are…

Applications · Statistics 2011-08-17 David Siegmund , Benjamin Yakir , Nancy R. Zhang

We study the frequentist properties of confidence intervals computed by the method known to statisticians as the Profile Likelihood. It is seen that the coverage of these intervals is surprisingly good over a wide range of possible…

Data Analysis, Statistics and Probability · Physics 2009-11-10 Wolfgang A. Rolke , Angel M. Lopez , Jan Conrad

In an empirical Bayes analysis, we use data from repeated sampling to imitate inferences made by an oracle Bayesian with extensive knowledge of the data-generating distribution. Existing results provide a comprehensive characterization of…

Methodology · Statistics 2021-09-09 Nikolaos Ignatiadis , Stefan Wager

Confidence interval procedures used in low dimensional settings are often inappropriate for high dimensional applications. When a large number of parameters are estimated, marginal confidence intervals associated with the most significant…

Methodology · Statistics 2017-02-24 Jean Morrison , Noah Simon

AB-testing is a very popular technique in web companies since it makes it possible to accurately predict the impact of a modification with the simplicity of a random split across users. One of the critical aspects of an AB-test is its…

Machine Learning · Statistics 2015-02-02 Cyrille Dubarry

A standard approach to computing expectations with respect to a given target measure is to introduce an overdamped Langevin equation which is reversible with respect to the target distribution, and to approximate the expectation by a…

Numerical Analysis · Mathematics 2016-04-20 A. B. Duncan , T. Lelievre , G. A. Pavliotis

Quantiles can represent key operational and business metrics, but the computational challenges associated with inference has hampered their adoption in online experimentation. One-sample confidence intervals are trivial to construct;…

Methodology · Statistics 2024-08-02 Evan Miller

We propose a method to remedy finite sample coverage problems and improve upon the efficiency of commonly employed procedures for the construction of nonparametric confidence intervals in regression kink designs. The proposed interval is…

Econometrics · Economics 2021-11-23 Majed Dodin

Motivated by the questions of risk assessment in climatology (temperature change in North America) and medicine (impact of statin usage and COVID-19 on hospitalized patients), we address the problem of estimating the set in the domain of a…

Methodology · Statistics 2025-04-29 Junting Ren , Fabian J. E. Telschow , Armin Schwartzman

We consider a general regression model, without a scale parameter. Our aim is to construct a confidence interval for a scalar parameter of interest $\theta$ that utilizes the uncertain prior information that a distinct scalar parameter…

Methodology · Statistics 2020-09-17 Paul Kabaila , Nishika Ranathunga

In this article, we derive an explicit formula for computing confidence interval for the mean of a bounded random variable. Moreover, we have developed multistage point estimation methods for estimating the mean value with prescribed…

Statistics Theory · Mathematics 2010-11-29 Xinjia Chen

We propose a nonparametric parameter estimation of confidence intervals when the underlying has large or infinite variance. We explain the method by a simple numerical example and provide an application to estimate the coupling strength in…

Statistics Theory · Mathematics 2022-04-26 Anirban Das , Manfred Denker , Anna Levina , Lucia Tabacu

We consider the problem of efficient inference of the Average Treatment Effect in a sequential experiment where the policy governing the assignment of subjects to treatment or control can change over time. We first provide a central limit…

Machine Learning · Statistics 2024-03-05 Thomas Cook , Alan Mishler , Aaditya Ramdas
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