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Understanding biological processes, drug development, and biotechnological advancements requires a detailed analysis of protein structures and functions, a task that is inherently complex and time-consuming in traditional protein research.…

With the continuous growth in the number of parameters of transformer-based pretrained language models (PLMs), particularly the emergence of large language models (LLMs) with billions of parameters, many natural language processing (NLP)…

Metadata attributes (e.g., user and product IDs from reviews) can be incorporated as additional inputs to neural-based NLP models, by modifying the architecture of the models, in order to improve their performance. Recent models however…

Background: The inception of next generations sequencing technologies have exponentially increased the volume of biological sequence data. Protein sequences, being quoted as the `language of life', has been analyzed for a multitude of…

Large Language Models (LLMs) demonstrate exceptional reasoning abilities, enabling strong generalization across diverse tasks such as commonsense reasoning and instruction following. However, as LLMs scale, inference costs become…

Fine-tuning is a popular method for adapting text-to-speech (TTS) models to new speakers. However this approach has some challenges. Usually fine-tuning requires several hours of high quality speech per speaker. There is also that…

Prompting and adapter tuning have emerged as efficient alternatives to fine-tuning (FT) methods. However, existing studies on speech prompting focused on classification tasks and failed on more complex sequence generation tasks. Besides,…

Although deep learning (DL) has achieved notable progress in speech enhancement (SE), further research is still required for a DL-based SE system to adapt effectively and efficiently to particular speakers. In this study, we propose a novel…

Large language models (LLMs) and vision language models (VLMs) demonstrate excellent performance on a wide range of tasks by scaling up parameter counts from O(10^9) to O(10^{12}) levels and further beyond. These large scales make it…

Visual Parameter-Efficient Fine-Tuning (PEFT) has become a powerful alternative for full fine-tuning so as to adapt pre-trained vision models to downstream tasks, which only tunes a small number of parameters while freezing the vast…

This paper introduces diffusion protein language model (DPLM), a versatile protein language model that demonstrates strong generative and predictive capabilities for protein sequences. We first pre-train scalable DPLMs from…

Large Language Models (LLMs) demonstrate impressive ability in handling reasoning tasks. However, unlike humans who can instinctively adapt their problem-solving strategies to the complexity of task, most LLM-based methods adopt a…

Due to the huge amount of parameters, fine-tuning of pretrained language models (PLMs) is prone to overfitting in the low resource scenarios. In this work, we present a novel method that operates on the hidden representations of a PLM to…

This paper introduces an approach that integrates self-adaptive Evolution Strategies (ES) with Large Language Models (LLMs) to enhance the explainability of complex optimization processes. By employing a self-adaptive ES equipped with a…

The parallels between protein sequences and natural language in their sequential structures have inspired the application of large language models (LLMs) to protein understanding. Despite the success of LLMs in NLP, their effectiveness in…

Vision-language models (VLMs) have demonstrated exceptional generalization capabilities for downstream tasks. Due to its efficiency, prompt learning has gradually become a more effective and efficient method for transferring VLMs to…

Parameter-efficient tuning aims to distill knowledge for downstream tasks by optimizing a few introduced parameters while freezing the pretrained language models (PLMs). Continuous prompt tuning which prepends a few trainable vectors to the…

Computational biology and bioinformatics provide vast data gold-mines from protein sequences, ideal for Language Models taken from NLP. These LMs reach for new prediction frontiers at low inference costs. Here, we trained two…

Building agentic systems that can autonomously self-improve from experience is a longstanding goal of AI. Large language models (LLMs) today primarily self-improve via two mechanisms: self-reflection for context updates, and reinforcement…

Recent advances in video captioning are driven by large-scale pretrained models, which follow the standard "pre-training followed by fine-tuning" paradigm, where the full model is fine-tuned for downstream tasks. Although effective, this…