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Deep neural networks for medical image classification often fail to generalize consistently in clinical practice due to violations of the i.i.d. assumption and opaque decision-making. This paper examines interpretability in deep neural…

Computer Vision and Pattern Recognition · Computer Science 2025-04-09 Mohammad Hossein Najafi , Mohammad Morsali , Mohammadreza Pashanejad , Saman Soleimani Roudi , Mohammad Norouzi , Saeed Bagheri Shouraki

Interpretability is a pressing issue for machine learning. Common approaches to interpretable machine learning constrain interactions between features of the input, rendering the effects of those features on a model's output comprehensible…

Machine Learning · Computer Science 2023-05-11 Kieran A. Murphy , Dani S. Bassett

Background: Effective allocation of limited donor lungs in cystic fibrosis (CF) requires accurate survival predictions, so that high-risk patients may be prioritized for transplantation. In practice, decisions about allocation are made…

Applications · Statistics 2017-06-30 Aasthaa Bansal , Nicole Mayer-Hamblett , Christopher H. Goss , Patrick J. Heagerty

The forecasting of the credit default risk has been an important research field for several decades. Traditionally, logistic regression has been widely recognized as a solution due to its accuracy and interpretability. As a recent trend,…

Computational Finance · Quantitative Finance 2022-09-22 Dangxing Chen , Weicheng Ye , Jiahui Ye

Feature selection is a critical component in predictive analytics that significantly affects the prediction accuracy and interpretability of models. Intrinsic methods for feature selection are built directly into model learning, providing a…

Machine Learning · Computer Science 2024-03-19 Theodor Stoecker , Nico Hambauer , Patrick Zschech , Mathias Kraus

Many medical decisions involve the use of dynamic information collected on individual patients toward predicting likely transitions in their future health status. If accurate predictions are developed, then a prognostic mode can identify…

Methodology · Statistics 2018-02-22 Aasthaa Bansal , Patrick J. Heagerty

In many applications, it is important to identify subpopulations that survive longer or shorter than the rest of the population. In medicine, for example, it allows determining which patients benefit from treatment, and in predictive…

Machine Learning · Computer Science 2026-02-26 Mhd Jawad Al Rahwanji , Sascha Xu , Nils Philipp Walter , Jilles Vreeken

Interpretability plays a vital role in aligning and deploying deep learning models in critical care, especially in constantly evolving conditions that influence patient survival. However, common interpretability algorithms face unique…

Machine Learning · Computer Science 2025-06-25 Shashank Yadav , Vignesh Subbian

Interpretability of machine learning models is critical for data-driven precision medicine efforts. However, highly predictive models are generally complex and are difficult to interpret. Here using Model-Agnostic Explanations algorithm, we…

Quantitative Methods · Quantitative Biology 2016-10-31 Gajendra Jung Katuwal , Robert Chen

A salient approach to interpretable machine learning is to restrict modeling to simple models. In the Bayesian framework, this can be pursued by restricting the model structure and prior to favor interpretable models. Fundamentally,…

Machine Learning · Computer Science 2020-09-08 Homayun Afrabandpey , Tomi Peltola , Juho Piironen , Aki Vehtari , Samuel Kaski

While multimodal survival prediction models are increasingly more accurate, their complexity often reduces interpretability, limiting insight into how different data sources influence predictions. To address this, we introduce DIMAFx, an…

Computer Vision and Pattern Recognition · Computer Science 2026-03-03 Aniek Eijpe , Soufyan Lakbir , Melis Erdal Cesur , Sara P. Oliveira , Angelos Chatzimparmpas , Sanne Abeln , Wilson Silva

Deep Neural Networks use thousands of mostly incomprehensible features to identify a single class, a decision no human can follow. We propose an interpretable sparse and low dimensional final decision layer in a deep neural network with…

Computer Vision and Pattern Recognition · Computer Science 2023-08-08 Thomas Norrenbrock , Marco Rudolph , Bodo Rosenhahn

The rapid accumulation of Electronic Health Records (EHRs) has transformed healthcare by providing valuable data that enhance clinical predictions and diagnoses. While conventional machine learning models have proven effective, they often…

Interpretable machine learning has emerged as central in leveraging artificial intelligence within high-stakes domains such as healthcare, where understanding the rationale behind model predictions is as critical as achieving high…

Machine Learning · Computer Science 2024-04-30 Christel Sirocchi , Martin Urschler , Bastian Pfeifer

A survival dataset describes a set of instances (e.g. patients) and provides, for each, either the time until an event (e.g. death), or the censoring time (e.g. when lost to follow-up - which is a lower bound on the time until the event).…

Machine Learning · Computer Science 2023-06-22 Ali Hossein Gharari Foomani , Michael Cooper , Russell Greiner , Rahul G. Krishnan

Model interpretability is an increasingly important component of practical machine learning. Some of the most common forms of interpretability systems are example-based, local, and global explanations. One of the main challenges in…

Machine Learning · Computer Science 2019-01-08 Gregory Plumb , Denali Molitor , Ameet Talwalkar

Social Networking Sites (SNS) are one of the most important ways of communication. In particular, microblogging sites are being used as analysis avenues due to their peculiarities (promptness, short texts...). There are countless researches…

Social and Information Networks · Computer Science 2022-06-28 Manuel Francisco , Juan Luis Castro

Understanding why a model made a certain prediction is crucial in many data science fields. Interpretable predictions engender appropriate trust and provide insight into how the model may be improved. However, with large modern datasets the…

Artificial Intelligence · Computer Science 2016-12-09 Scott Lundberg , Su-In Lee

Machine learning applications for longitudinal electronic health records often forecast the risk of events at fixed time points, whereas survival analysis achieves dynamic risk prediction by estimating time-to-event distributions. Here, we…

Machine Learning · Computer Science 2024-11-26 Munib Mesinovic , Peter Watkinson , Tingting Zhu

Survival analysis is a challenging variation of regression modeling because of the presence of censoring, where the outcome measurement is only partially known, due to, for example, loss to follow up. Such problems come up frequently in…

Machine Learning · Computer Science 2022-06-28 Chirag Nagpal , Steve Yadlowsky , Negar Rostamzadeh , Katherine Heller
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