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Brain digital twins aim to provide faithful, individualized computational representations of brains as dynamical systems, enabling mechanistic understanding and supporting prediction of clinical interventions. Yet current approaches remain…

Computational Engineering, Finance, and Science · Computer Science 2026-04-16 Alexandre Muzy

Simulation-based digital twins must provide accurate, robust and reliable digital representations of their physical counterparts. Quantifying the uncertainty in their predictions plays, therefore, a key role in making better-informed…

Computational Engineering, Finance, and Science · Computer Science 2024-10-14 Daniel Andrés Arcones , Martin Weiser , Phaedon-Stelios Koutsourelakis , Jörg F. Unger

The widespread adoption of Electric Vehicles (EVs) is limited by their reliance on batteries with presently low energy and power densities compared to liquid fuels and are subject to aging and performance deterioration over time. For this…

Machine Learning · Computer Science 2022-06-17 Khaled Sidahmed Sidahmed Alamin , Yukai Chen , Enrico Macii , Massimo Poncino , Sara Vinco

Reinforcement Learning (RL) or Deep Reinforcement Learning (DRL) is a powerful approach to solving Markov Decision Processes (MDPs) when the model of the environment is not known a priori. However, RL models are still faced with challenges…

Systems and Control · Electrical Eng. & Systems 2024-06-04 Kabirat Olayemi , Mien Van , Luke Maguire , Sean McLoone

We focus on collaborative activities that engage computer graphics designers and social scientists in systems design processes. Our conceptual symmetrical account of technology design and theory development is elaborated as a mode of mutual…

Computers and Society · Computer Science 2020-06-11 Cornelius Schubert , Andreas Kolb

Digital twins have attracted a great deal of recent attention from a wide range of fields. A basic requirement for digital twins of nonlinear dynamical systems is the ability to generate the system evolution and predict potentially…

Machine Learning · Computer Science 2023-09-21 Ying-Cheng Lai

Digital twins are models of real-world systems that can simulate their dynamics in response to potential actions. In complex settings, the state and action variables, and available data and knowledge relevant to a system can constantly…

Computation and Language · Computer Science 2025-07-23 Harry Amad , Nicolás Astorga , Mihaela van der Schaar

Iterative cycles of theoretical prediction and experimental validation are the cornerstone of the modern scientific method. However, the proverbial "closing of the loop" in experiment-theory cycles in practice are usually ad hoc, often…

Digital Twin technology creates virtual replicas of physical objects, processes, or systems by replicating their properties, data, and behaviors. This advanced technology offers a range of intelligent functionalities, such as modeling,…

Machine Learning · Computer Science 2024-08-26 Sagar Srinivas Sakhinana , Krishna Sai Sudhir Aripirala , Shivam Gupta , Venkataramana Runkana

Insufficient data volume and quality are particularly pressing challenges in the adoption of modern subsymbolic AI. To alleviate these challenges, AI simulation uses virtual training environments in which AI agents can be safely and…

Artificial Intelligence · Computer Science 2025-09-01 Xiaoran Liu , Istvan David

The Design of Experiments (DOEs) is a fundamental scientific methodology that provides researchers with systematic principles and techniques to enhance the validity, reliability, and efficiency of experimental outcomes. In this study, we…

Machine Learning · Statistics 2025-07-22 Miao Huang , Hongqiao Wang , Kunyu Wu

Given that observational and numerical climate data are being produced at ever more prodigious rates, increasingly sophisticated and automated analysis techniques have become essential. Deep learning is quickly becoming a standard approach…

Fluid Dynamics · Physics 2017-09-12 A. Rupe , J. P. Crutchfield , K. Kashinath , Prabhat

This work proposes a mathematical framework to increase the robustness to rare events of digital twins modelled with graphical models. We incorporate probabilistic model-checking and linear programming into a dynamic Bayesian network to…

Numerical Analysis · Mathematics 2024-08-27 Marco Tezzele , Steven Carr , Ufuk Topcu , Karen E. Willcox

This paper presents a proof-of-concept digital twin framework for simulation-driven diabetes modeling using benchmark clinical data, synthetic temporal augmentation, and illustrative continuous glucose monitoring (CGM) analysis. Unlike…

Machine Learning · Computer Science 2026-05-13 Zarrin Monirzadeh

In this manuscript a method for developing novel filtering algorithms through the parallel concatenation of two Bayesian filters is illustrated. Our description of this method, called turbo filtering, is based on a new graphical model; this…

Computation · Statistics 2018-06-14 Giorgio M. Vitetta , Pasquale Di Viesti , Emilio Sirignano , Francesco Montorsi

Experimental design is crucial for inference where limitations in the data collection procedure are present due to cost or other restrictions. Optimal experimental designs determine parameters that in some appropriate sense make the data…

Machine Learning · Statistics 2016-03-11 Panagiotis Tsilifis , Roger G. Ghanem , Paris Hajali

The integration of accurate and reproducible wireless network simulations is a key enabler for research on open, virtualized, and intelligent communication systems. Network Digital Twins (NDTs) provide a scalable alternative to costly and…

Networking and Internet Architecture · Computer Science 2026-04-15 Oscar Stenhammar , Sundeep Rangan , Gábor Fodor , Carlo Fischione

We develop an approach for Bayesian learning of spatiotemporal dynamical mechanistic models. Such learning consists of statistical emulation of the mechanistic system that can efficiently interpolate the output of the system from arbitrary…

Methodology · Statistics 2025-07-11 Sudipto Banerjee , Xiang Chen , Ian Frankenburg , Daniel Zhou

The design of structural & functional materials for specialized applications is being fueled by rapid advancements in materials synthesis, characterization, manufacturing, with sophisticated computational materials modeling frameworks that…

This work demonstrates that neural operator learning provides a powerful and flexible framework for building fast, accurate emulators of moving boundary systems, enabling their integration into digital twin platforms. To this end, a Deep…

Machine Learning · Computer Science 2025-12-24 Marco A. Iglesias , Michael. E. Causon , Mikhail Y. Matveev , Andreas Endruweit , Michael . V. Tretyakov