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The assessment of imaging biomarkers is critical for advancing precision medicine and improving disease characterization. Despite the availability of methods to derive disease heterogeneity metrics in imaging studies, a robust framework for…

One of the key limitations of Molecular Dynamics simulations is the computational intractability of sampling protein conformational landscapes associated with either large system size or long timescales. To overcome this bottleneck, we…

Biomolecules · Quantitative Biology 2018-07-09 Zahra Shamsi , Kevin J. Cheng , Diwakar Shukla

In this article, we develop fully Bayesian, copula-based, spatial-statistical models for large, noisy, incomplete, and non-Gaussian spatial data. Our approach includes novel constructions of copulas that accommodate a spatial-random-effects…

Methodology · Statistics 2025-11-05 Alan Pearse , David Gunawan , Noel Cressie

Active learning selects informative samples for annotation within budget, which has proven efficient recently on object detection. However, the widely used active detection benchmarks conduct image-level evaluation, which is unrealistic in…

Computer Vision and Pattern Recognition · Computer Science 2023-03-24 Mengyao Lyu , Jundong Zhou , Hui Chen , Yijie Huang , Dongdong Yu , Yaqian Li , Yandong Guo , Yuchen Guo , Liuyu Xiang , Guiguang Ding

Dependence strucuture estimation is one of the important problems in machine learning domain and has many applications in different scientific areas. In this paper, a theoretical framework for such estimation based on copula and copula…

Machine Learning · Computer Science 2019-09-11 Jian Ma , Zengqi Sun

We propose a new highly flexible and tractable Bayesian approach to undertake variable selection in non-Gaussian regression models. It uses a copula decomposition for the joint distribution of observations on the dependent variable. This…

Methodology · Statistics 2020-09-07 Nadja Klein , Michael Stanley Smith

Identifying parameters of computational models from experimental data, or model calibration, is fundamental for assessing and improving the predictability and reliability of computer simulations. In this work, we propose a method for…

Computational Physics · Physics 2023-08-07 Lianghao Cao , Keyi Wu , J. Tinsley Oden , Peng Chen , Omar Ghattas

In recent years dynamical modelling has been provided with a range of breakthrough methods to perform exact Bayesian inference. However it is often computationally unfeasible to apply exact statistical methodologies in the context of large…

Computation · Statistics 2014-12-24 Umberto Picchini , Julie Lyng Forman

We propose a new test for the hypothesis that a bivariate copula is an Archimedean copula. The test statistic is based on a combination of two measures resulting from the characterization of Archimedean copulas by the property of…

Statistics Theory · Mathematics 2011-09-30 Axel Bücher , Holger Dette , Stanislav Volgushev

Adaptive tracking-by-detection approaches are popular for tracking arbitrary objects. They treat the tracking problem as a classification task and use online learning techniques to update the object model. However, these approaches are…

Computer Vision and Pattern Recognition · Computer Science 2017-04-04 Kourosh Meshgi , Maryam Sadat Mirzaei , Shigeyuki Oba , Shin Ishii

This paper presents a fast and modular framework for Multi-Object Tracking (MOT) based on the Markov descision process (MDP) tracking-by-detection paradigm. It is designed to allow its various functional components to be replaced by…

Computer Vision and Pattern Recognition · Computer Science 2023-10-24 Abhineet Singh

Evidence accumulation models (EAMs) are an important class of cognitive models used to analyze both response time and response choice data recorded from decision-making tasks. Developments in estimation procedures have helped EAMs become…

Methodology · Statistics 2023-06-01 Viet Hung Dao , David Gunawan , Robert Kohn , Minh-Ngoc Tran , Guy E. Hawkins , Scott D. Brown

Structured additive distributional copula regression allows to model the joint distribution of multivariate outcomes by relating all distribution parameters to covariates. Estimation via statistical boosting enables accounting for…

Active search is a learning paradigm for actively identifying as many members of a given class as possible. A critical target scenario is high-throughput screening for scientific discovery, such as drug or materials discovery. In this…

Machine Learning · Computer Science 2018-11-27 Shali Jiang , Gustavo Malkomes , Benjamin Moseley , Roman Garnett

Reinforcement learning and data-driven autonomous controllers are commonly evaluated using cumulative reward and empirical success frequency under finite simulation trajectories. However, such empirical metrics do not necessarily provide…

Machine Learning · Computer Science 2026-05-28 Fei Jiang , Lei Yang

Biological systems are often modeled as a system of ordinary differential equations (ODEs) with time-invariant parameters. However, cell signaling events or pharmacological interventions may alter the cellular state and induce multi-mode…

Quantitative Methods · Quantitative Biology 2020-04-28 Bing Liu

Multi-object tracking (MOT) in team sports is particularly challenging due to the fast-paced motion and frequent occlusions resulting in motion blur and identity switches, respectively. Predicting player positions in such scenarios is…

Computer Vision and Pattern Recognition · Computer Science 2025-06-05 Dheeraj Khanna , Jerrin Bright , Yuhao Chen , John S. Zelek

Current causal discovery approaches require restrictive model assumptions in the absence of interventional data to ensure structure identifiability. These assumptions often do not hold in real-world applications leading to a loss of…

Machine Learning · Statistics 2025-06-25 Anish Dhir , Ruby Sedgwick , Avinash Kori , Ben Glocker , Mark van der Wilk

In standardized educational testing, test items are reused in multiple test administrations. To ensure the validity of test scores, the psychometric properties of items should remain unchanged over time. In this paper, we consider the…

Applications · Statistics 2021-10-26 Yunxiao Chen , Yi-Hsuan Lee , Xiaoou Li

The rigorous safety verification of control systems in critical applications is essential, given their increasing complexity and integration into everyday life. Simulation-based falsification approaches play a pivotal role in the safety…

Systems and Control · Electrical Eng. & Systems 2024-03-13 Joshua Yancosek , Ali Baheri
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