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In electronic health records (EHRs), clustering patients and distinguishing disease subtypes are key tasks to elucidate pathophysiology and aid clinical decision-making. However, clustering in healthcare informatics is still based on…

Machine Learning · Computer Science 2026-04-09 Manar D. Samad , Yina Hou , Shrabani Ghosh

Electronic health records (EHRs) and other real-world clinical data are essential for clinical research, medical artificial intelligence, and life science, but their sharing is severely limited by privacy, governance, and interoperability…

Cryptography and Security · Computer Science 2026-03-25 Maolin Wang , Beining Bao , Gan Yuan , Hongyu Chen , Bingkun Zhao , Baoshuo Kan , Jiming Xu , Qi Shi , Yinggong Zhao , Yao Wang , Wei Ying Ma , Jun Yan

The development of robust clinical decision support systems is frequently impeded by the scarcity of high-fidelity, privacy-preserving biomedical data. While Generative Large Language Models (LLMs) offer a promising avenue for synthetic…

Machine Learning · Computer Science 2026-04-03 Arshia Ilaty , Hossein Shirazi , Amir Rahmani , Hajar Homayouni

The recent availability of electronic health records (EHRs) have provided enormous opportunities to develop artificial intelligence (AI) algorithms. However, patient privacy has become a major concern that limits data sharing across…

Machine Learning · Computer Science 2023-02-01 Jin Li , Benjamin J. Cairns , Jingsong Li , Tingting Zhu

Despite continued advancement in recent years, deep neural networks still rely on large amounts of training data to avoid overfitting. However, labeled training data for real-world applications such as healthcare is limited and difficult to…

The presence of detailed clinical information in electronic health record (EHR) systems presents promising prospects for enhancing patient care through automated retrieval techniques. Nevertheless, it is widely acknowledged that accessing…

Information Retrieval · Computer Science 2024-09-13 Abderrahim Oussama Batouche , Eugen Czeizler , Miika Koskinen , Tuomas Mirtti , Antti Sakari Rannikko

Diffusion models have been widely used in the generative domain due to their convincing performance in modeling complex data distributions. Moreover, they have shown competitive results on discriminative tasks, such as image segmentation.…

Sound · Computer Science 2025-01-14 Hounsu Kim , Taegyun Kwon , Juhan Nam

Electronic Health Records (EHRs) contain extensive patient information that can inform downstream clinical decisions, such as mortality prediction, disease phenotyping, and disease onset prediction. A key challenge in EHR data analysis is…

Applications · Statistics 2026-01-01 Xin Gai , Shiyi Jiang , Anru R. Zhang

Generative AI presents chemists with novel ideas for drug design and facilitates the exploration of vast chemical spaces. Diffusion models (DMs), an emerging tool, have recently attracted great attention in drug R\&D. This paper…

Biomolecules · Quantitative Biology 2025-07-14 Peining Zhang , Daniel Baker , Minghu Song , Jinbo Bi

Diffusion models are a powerful tool for probabilistic forecasting, yet most applications in high-dimensional complex systems predict future states individually. This approach struggles to model complex temporal dependencies and fails to…

Machine Learning · Computer Science 2025-12-10 Salva Rühling Cachay , Miika Aittala , Karsten Kreis , Noah Brenowitz , Arash Vahdat , Morteza Mardani , Rose Yu

Generating synthetic ECG data has numerous applications in healthcare, from educational purposes to simulating scenarios and forecasting trends. While recent diffusion models excel at generating short ECG segments, they struggle with longer…

Signal Processing · Electrical Eng. & Systems 2025-05-27 Paul Pöhl , Viktor Schlegel , Hao Li , Anil Bharath

Generative models play an important role in missing data imputation in that they aim to learn the joint distribution of full data. However, applying advanced deep generative models (such as Diffusion models) to missing data imputation is…

Machine Learning · Computer Science 2025-05-27 Hengrui Zhang , Liancheng Fang , Qitian Wu , Philip S. Yu

Synthesizing high-quality tabular data is an important topic in many data science tasks, ranging from dataset augmentation to privacy protection. However, developing expressive generative models for tabular data is challenging due to its…

Machine Learning · Computer Science 2025-02-18 Juntong Shi , Minkai Xu , Harper Hua , Hengrui Zhang , Stefano Ermon , Jure Leskovec

The scarcity of publicly available medical imaging data limits the development of effective AI models. This work proposes a memory-efficient patch-wise denoising diffusion probabilistic model (DDPM) for generating synthetic medical images,…

Image and Video Processing · Electrical Eng. & Systems 2024-10-17 Kathrin Khadra , Utku Türkbey

Diffusion Probabilistic Models (DPMs) are generative models showing competitive performance in various domains, including image synthesis and 3D point cloud generation. Sampling from pre-trained DPMs involves multiple neural function…

Machine Learning · Computer Science 2025-05-21 Vinh Tong , Hoang Trung-Dung , Anji Liu , Guy Van den Broeck , Mathias Niepert

Despite the ever-increasing interest in applying deep learning (DL) models to medical imaging, the typical scarcity and imbalance of medical datasets can severely impact the performance of DL models. The generation of synthetic data that…

Image and Video Processing · Electrical Eng. & Systems 2023-04-03 Pouria Rouzrokh , Bardia Khosravi , Shahriar Faghani , Mana Moassefi , Sanaz Vahdati , Bradley J. Erickson

The broad adoption of Electronic Health Records (EHR) has led to vast amounts of data being accumulated on a patient's history, diagnosis, prescriptions, and lab tests. Advances in recommender technologies have the potential to utilize this…

Information Retrieval · Computer Science 2020-09-01 Suman Bhoi , Lee Mong Li , Wynne Hsu

While the volume of electronic health records (EHR) data continues to grow, it remains rare for hospital systems to capture dense physiological data streams, even in the data-rich intensive care unit setting. Instead, typical EHR records…

Machine Learning · Computer Science 2018-12-04 Satya Narayan Shukla , Benjamin M. Marlin

Diffusion models have become a standard approach for generative modeling in continuous domains, yet their application to discrete data remains challenging. We investigate why Gaussian diffusion models with the DDPM solver struggle to sample…

Computation and Language · Computer Science 2026-05-28 Alexander Shabalin , Simon Elistratov , Viacheslav Meshchaninov , Ildus Sadrtdinov , Dmitry Vetrov

Generative modeling of 3D LiDAR data is an emerging task with promising applications for autonomous mobile robots, such as scalable simulation, scene manipulation, and sparse-to-dense completion of LiDAR point clouds. While existing…

Computer Vision and Pattern Recognition · Computer Science 2024-03-05 Kazuto Nakashima , Ryo Kurazume