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Accurate prediction of energy and forces for 3D molecular systems is one of fundamental challenges at the core of AI for Science applications. Many powerful and data-efficient neural networks predict molecular energies and forces from…

Chemical Physics · Physics 2026-04-23 Ali Mollahosseini , Mohammed Haroon Dupty , Wee Sun Lee

In this two-part paper, we present a novel framework and methodology to analyze data from certain image-based biochemical assays, e.g., ELISPOT and Fluorospot assays. In this first part, we start by presenting a physical partial…

Signal Processing · Electrical Eng. & Systems 2018-10-19 Pol del Aguila Pla , Joakim Jaldén

Mesoscopic non-equilibrium thermodynamics is used to formulate a model describing non-homogeneous and non-Debye dielectric relaxation. The model is presented in terms of a Fokker-Planck equation for the probability distribution of…

Statistical Mechanics · Physics 2015-05-19 Humberto Hijar , J. G. Mendez-Bermudez , I. Santamaria-Holek

We develop the neural network based "learning from regression uncertainty" approach for automated detection of phases of matter in nonequilibrium active systems. Taking the flocking phase transition of self-propelled active particles…

Disordered Systems and Neural Networks · Physics 2023-11-09 Wei-Chen Guo , Bao-Quan Ai , Liang He

Many important tasks in chemistry revolve around molecules during reactions. This requires predictions far from the equilibrium, while most recent work in machine learning for molecules has been focused on equilibrium or near-equilibrium…

Machine Learning · Computer Science 2022-04-06 Johannes Gasteiger , Shankari Giri , Johannes T. Margraf , Stephan Günnemann

Masked diffusion models (MDMs) have achieved notable progress in modeling discrete data, while their potential in molecular generation remains underexplored. In this work, we explore their potential and introduce the surprising result that…

Machine Learning · Computer Science 2025-09-29 Hyunjin Seo , Taewon Kim , Sihyun Yu , SungSoo Ahn

Data scarcity, bias, and experimental noise are all frequently encountered problems in the application of deep learning to chemical and material science disciplines. Transfer learning has proven effective in compensating for the lack in…

Chemical Physics · Physics 2021-03-16 Florence H. Vermeire , William H. Green

We discuss certain basic features of the equation-free (EF) approach to modeling and computation for complex/multiscale systems. We focus on links between the equation-free approach and tools from systems and control theory (design of…

Cellular Automata and Lattice Gases · Physics 2007-05-23 C. I. Siettos , R. Rico-Martinez , I. G. kevrekidis

Equivariant neural networks exploit underlying task symmetries to improve generalization, but strict equivariance constraints can induce more complex optimization dynamics that can hinder learning. Prior work addresses these limitations by…

Machine Learning · Computer Science 2026-02-24 Stefanos Pertigkiozoglou , Mircea Petrache , Shubhendu Trivedi , Kostas Daniilidis

A central problem in machine learning involves modeling complex data-sets using highly flexible families of probability distributions in which learning, sampling, inference, and evaluation are still analytically or computationally…

Machine Learning · Computer Science 2015-11-20 Jascha Sohl-Dickstein , Eric A. Weiss , Niru Maheswaranathan , Surya Ganguli

We derive and analyze a novel approach for modeling and computing the mechanical relaxation of incommensurate 2D heterostructures. Our approach parametrizes the relaxation pattern by the compact local configuration space rather than real…

Computational Physics · Physics 2019-09-04 Paul Cazeaux , Mitchell Luskin , Daniel Massatt

Cells can utilize chemical communication to exchange information and coordinate their behavior in the presence of noise. Communication can reduce noise to shape a collective response, or amplify noise to generate distinct phenotypic…

Molecular Networks · Quantitative Biology 2019-09-24 David T. Gonzales , T-Y Dora Tang , Christoph Zechner

Viscoelastic properties of polymer melts are particularly challenging to compute due to the intrinsic stress fluctuations in molecular dynamics (MD). We compared equilibrium and non-equilibrium MD approaches for extracting the storage (G')…

Soft Condensed Matter · Physics 2022-05-14 Oluseye Adeyemi , Shiping Zhu , Li Xi

Analysis of reactive-diffusion simulations requires a large number of independent model runs. For each high-fidelity simulation, inputs are varied and the predicted mixing behavior is represented by changes in species concentration. It is…

Computational Engineering, Finance, and Science · Computer Science 2019-07-24 V. V. Vesselinov , M. K. Mudunuru , S. Karra , D. O. Malley , B. S. Alexandrov

Nonlinear conservation laws govern a broad class of important physical systems in science and industry and are central to scientific machine learning (SciML). Large general-purpose models offer speed, but replacing the numerical and…

Machine Learning · Computer Science 2026-05-19 J. Antonio Lara Benitez , Kareem Hegazy , Junyi Guo , Ivan Dokmanić , Michael W. Mahoney , Maarten V. de Hoop

Capturing the structural changes that molecules undergo during chemical reactions in real space and time is a long-standing dream and an essential prerequisite for understanding and ultimately controlling femtochemistry. A key approach to…

Unveiling the underlying governing equations of nonlinear dynamic systems remains a significant challenge. Insufficient prior knowledge hinders the determination of an accurate candidate library, while noisy observations lead to imprecise…

Machine Learning · Computer Science 2024-04-30 Mengge Du , Yuntian Chen , Longfeng Nie , Siyu Lou , Dongxiao Zhang

Generative diffusion models have emerged as powerful tools for sampling high-dimensional distributions, yet they typically rely on white gaussian noise and noise schedules to destroy and reconstruct information. Here, we demonstrate that…

We train an equivariant machine learning model to predict energies and forces for a real-world study of hydrogen combustion under conditions of finite temperature and pressure. This challenging case for reactive chemistry illustrates that…

Chemical Physics · Physics 2023-06-16 Xingyi Guan , Joseph Heindel , Taehee Ko , Chao Yang , Teresa Head-Gordon

Neural Network Potentials (NNPs) have emerged as a powerful tool for modelling atomic interactions with high accuracy and computational efficiency. Recently, denoising diffusion models have shown promise in NNPs by training networks to…

Machine Learning · Computer Science 2025-04-07 Liam Harcombe , Timothy T. Duignan