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The activity and dynamics of excitable cells are fundamentally regulated and moderated by extracellular and intracellular ion concentrations and their electric potentials. The increasing availability of dense reconstructions of excitable…

Numerical Analysis · Mathematics 2024-03-08 Pietro Benedusi , Ada J. Ellingsrud , Halvor Herlyng , Marie E. Rognes

Mathematical models for excitable cells are commonly based on cable theory, which considers a homogenized domain and spatially constant ionic concentrations. Although such models provide valuable insight, the effect of altered ion…

Computational Engineering, Finance, and Science · Computer Science 2019-11-11 A. J. Ellingsrud , A. Solbrå , G. T. Einevoll , G. Halnes , M. E. Rognes

In the present study, we consider the Extra-Membrane-Intra model (EMI) for the simulation of excitable tissues at the cellular level. We provide the (possibly large) system of partial differential equations (PDEs), equipped with ad hoc…

Numerical Analysis · Mathematics 2024-09-23 Pietro Benedusi , Paola Ferrari , Marius Causemann , Stefano Serra-Capizzano

We formulate and analyze interior penalty discontinuous Galerkin methods for coupled elliptic PDEs modeling excitable tissue, represented by intracellular and extracellular domains sharing a common interface. The PDEs are coupled through a…

Numerical Analysis · Mathematics 2024-11-06 Rami Masri , Keegan L. A. Kirk , Eirill Hauge , Miroslav Kuchta

In this work, we are interested in solving large linear systems stemming from the Extra-Membrane-Intra (EMI) model, which is employed for simulating excitable tissues at a cellular scale. After setting the related systems of partial…

Numerical Analysis · Mathematics 2023-08-24 Pietro Benedusi , Paola Ferrari , Marie Rognes , Stefano Serra-Capizzano

This work concerns the numerical solution of a coupled system of self-consistent reaction-drift-diffusion-Poisson equations that describes the macroscopic dynamics of charge transport in photoelectrochemical (PEC) solar cells with reactive…

Numerical Analysis · Mathematics 2017-03-16 Michael Harmon , Irene M. Gamba , Kui Ren

The robust, scalable simulation of flowing electrochemical systems is increasingly important due to the synergy between intermittent renewable energy and electrochemical technologies such as energy storage and chemical manufacturing. The…

Numerical Analysis · Mathematics 2022-12-21 Thomas Roy , Julian Andrej , Victor A. Beck

A high-order accurate implicit-mesh discontinuous Galerkin framework for wave propagation in single-phase and bi-phase solids is presented. The framework belongs to the embedded-boundary techniques and its novelty regards the spatial…

Numerical Analysis · Mathematics 2022-05-11 Vincenzo Gulizzi , Robert Saye

Matrix-free geometric multigrid solvers for elliptic PDEs that have been discretised with Higher-order Discontinuous Galerkin (DG) methods are ideally suited to exploit state-of-the-art computer architectures. Higher polynomial degrees…

Numerical Analysis · Mathematics 2025-10-02 Sean Baccas , Alexander A. Belozerov , Eike H. Müller , Tobias Weinzierl

A dispersive wave hydro-morphodynamic model coupling the Green-Naghdi equations (the hydrodynamic part) with the sediment continuity Exner equation (the morphodynamic part) is presented. Numerical solution algorithms based on discontinuous…

Numerical Analysis · Mathematics 2021-02-03 Kazbek Kazhyken , Juha Videman , Clint Dawson

A dispersive wave hydro-sediment-morphodynamic model developed by complementing the shallow water hydro-sediment-morphodynamic (SHSM) equations with the dispersive term from the Green-Naghdi equations is presented. A numerical solution…

Numerical Analysis · Mathematics 2021-02-24 Kazbek Kazhyken , Juha Videman , Clint Dawson

We present and analyze a high-order discontinuous Galerkin method for the space discretization of the wave propagation model in thermo-poroelastic media. The proposed scheme supports general polytopal grids. Stability analysis and…

Numerical Analysis · Mathematics 2023-06-28 Stefano Bonetti , Michele Botti , Ilario Mazzieri , Paola F. Antonietti

We develop a high order accurate numerical method for solving the elastic wave equation in second-order form. We hybridize the computationally efficient Cartesian grid formulation of finite differences with geometrically flexible…

Numerical Analysis · Mathematics 2025-02-04 Andreas Granath , Siyang Wang

The propagation of electromagnetic waves in general media is modeled by the time-dependent Maxwell's partial differential equations (PDEs), coupled with constitutive laws that describe the response of the media. In this work, we focus on…

Numerical Analysis · Mathematics 2017-10-11 Vrushali A. Bokil , Yingda Cheng , Yan Jiang , Fengyan Li

The EMI (Extracellular-Membrane-Intracellular) model describes electrical activity in excitable tissue, where the extracellular and intracellular spaces and cellular membrane are explicitly represented. The model couples a system of partial…

Numerical Analysis · Mathematics 2023-07-06 Nanna Berre , Marie E. Rognes , Andre Massing

In this work, we investigate the propagation of electromagnetic waves in the Cole-Cole dispersive medium by using the discontinuous Galerkin (DG) method to solve the coupled time-domain Maxwell's equations and polarization equation. We…

Numerical Analysis · Mathematics 2022-08-25 Jiangming Xie , Maojun Li , Miao-Jung Yvonne Ou

The Poisson-Nernst-Planck (PNP) system is a standard model for describing ion transport. In many applications, e.g., ions in biological tissues, the presence of thin boundary layers poses both modelling and computational challenges. In a…

Biological Physics · Physics 2018-06-22 Zilong Song , Xiulei Cao , Huaxiong Huang

In recent years, deep learning methods, exemplified by Physics-Informed Neural Networks (PINNs), have been widely applied to the numerical solution of differential equations. However, these methods may suffer from limited accuracy, high…

Numerical Analysis · Mathematics 2026-03-17 Tao Tang , Jiang Yang , Yuxiang Zhao , Quanhui Zhu

In this work, we propose an accurate, robust, and stable discretization of the gamma-based compressible multicomponent model by Shyue [J. Comput. Phys., 142 (1998), 208-242] where each component follows a stiffened gas equation of state…

Numerical Analysis · Mathematics 2025-10-10 Rémi Abgrall , Pratik Rai , Florent Renac

The discontinuous Galerkin (DG) method is an established method for computing approximate solutions of partial differential equations in many applications. Unlike continuous finite elements, in DG methods, numerical fluxes are used to…

Numerical Analysis · Mathematics 2019-12-02 Kenneth Duru , Leonhard Rannabauer , Alice-Agnes Gabriel , Heiner Igel
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