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Classifying samples in incomplete datasets is a common aim for machine learning practitioners, but is non-trivial. Missing data is found in most real-world datasets and these missing values are typically imputed using established methods,…

Healthcare professionals have long envisioned using the enormous processing powers of computers to discover new facts and medical knowledge locked inside electronic health records. These vast medical archives contain time-resolved…

Machine Learning · Computer Science 2020-05-15 Ahmed Allam , Matthias Dittberner , Anna Sintsova , Dominique Brodbeck , Michael Krauthammer

Multilevel compositional data are data that are repeatedly measured or clustered within groups and are non-negative and sum to a constant value. These data arise in various settings, such as intensive, longitudinal studies using ecological…

Methodology · Statistics 2025-02-21 Flora Le , Tyman E. Stanford , Dorothea Dumuid , Joshua F. Wiley

Missing data are ubiquitous in empirical databases, yet statistical analyses typically require complete data matrices. Multiple imputation offers a principled solution for filling these gaps. This study evaluates the performance of several…

Computation · Statistics 2026-02-05 Enzo Porto Brasil

Electronic health records (EHRs) are increasingly used for clinical and comparative effectiveness research, but suffer from missing data. Motivated by health services research on diabetes care, we seek to increase the quality of EHRs by…

Methodology · Statistics 2020-07-14 Yajuan Si , Mari Palta , Maureen Smith

Joint models of longitudinal and event-time data have been extensively studied and applied in many different fields. Estimation of joint models is challenging, most present procedures are computational expensive and have a strict…

Methodology · Statistics 2018-09-05 Yanqiao Zheng , Xiaobing Zhao , Xiaoqi Zhang

In pharmacoepidemiology, safety and effectiveness are frequently evaluated using readily available administrative and electronic health records data. In these settings, detailed confounder data are often not available in all data sources…

Methods for addressing missing data have become much more accessible to applied researchers. However, little guidance exists to help researchers systematically identify plausible missing data mechanisms in order to ensure that these methods…

Applications · Statistics 2020-07-29 Adam Davey , Ting Dai

Multiple imputation (MI) has been widely applied to missing value problems in biomedical, social and econometric research, in order to avoid improper inference in the downstream data analysis. In the presence of high-dimensional data,…

Methodology · Statistics 2023-05-04 Zhiqi Bu , Zongyu Dai , Yiliang Zhang , Qi Long

Understanding whether and how treatment effects vary across subgroups is crucial to inform clinical practice and recommendations. Accordingly, the assessment of heterogeneous treatment effects (HTE) based on pre-specified potential effect…

Methodology · Statistics 2023-12-04 Bryan S. Blette , Scott D. Halpern , Fan Li , Michael O. Harhay

Clinical trials that investigate interventions on physical activity often use accelerometers to measure step count at a very granular level, often in 5-second epochs. Participants typically wear the accelerometer for a week-long period at…

Missing values are largely inevitable in gene expression microarray studies. Data sets often have significant omissions due to individuals dropping out of experiments, errors in data collection, image corruptions, and so on. Missing data…

Quantitative Methods · Quantitative Biology 2018-09-18 Marie Li

In epidemiological and clinical studies, identifying patients' phenotypes based on longitudinal profiles is critical to understanding the disease's developmental patterns. The current study was motivated by data from a Canadian birth cohort…

Methodology · Statistics 2023-03-22 Zhiwen Tan , Chang Shen , Padmaja Subbarao , Wendy Lou , Zihang Lu

Finite mixture models have become a popular tool for clustering. Amongst other uses, they have been applied for clustering longitudinal data and clustering high-dimensional data. In the latter case, a latent Gaussian mixture model is…

Methodology · Statistics 2018-04-17 Vanessa S. E. Bierling , Paul D. McNicholas

Personalizing interventions and treatments is a necessity for optimal medical care. Recent advances in computing, such as personal electronic devices, have made it easier than ever to collect and utilize vast amounts of personal data on…

Computers and Society · Computer Science 2017-11-16 Orianna DeMasi , Benjamin Recht

This paper proposes an analysis methodology for the case where there is longitudinal data with destructive sampling of observational units, which come from experimental units that are measured at all times of the analysis. A mixed linear…

Methodology · Statistics 2024-11-26 C. A. Avellaneda , O. O. Melo , N. A. Cruz

Multiple imputation is widely used for handling missing data in real-world applications. For variable selection on multiply-imputed datasets, however, if selection is performed on each imputed dataset separately, it can result in different…

Methodology · Statistics 2025-08-07 Jungang Zou , Sijian Wang , Qixuan Chen

Physics education researchers (PER) commonly use complete-case analysis to address missing data. For complete-case analysis, researchers discard all data from any student who is missing any data. Despite its frequent use, no PER article we…

Physics Education · Physics 2019-02-20 Jayson Nissen , Robin Donatello , Ben Van Dusen

Missing values are ubiquitous in multivariate time series (MTS) data, posing significant challenges for accurate analysis and downstream applications. In recent years, deep learning-based methods have successfully handled missing data by…

Machine Learning · Computer Science 2025-05-21 Jun Wang , Wenjie Du , Yiyuan Yang , Linglong Qian , Wei Cao , Keli Zhang , Wenjia Wang , Yuxuan Liang , Qingsong Wen

When the distribution of treatment effect modifiers differs between the trial sample and target population, inverse probability weighting (IPSW) can be applied to achieve an unbiased estimate of the population average treatment effect in…

Applications · Statistics 2022-03-04 Albee Y. Ling , Maria E. Montez-Rath , Kris Kapphahn , Manisha Desai