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The structural identifiability and the observability of a model determine the possibility of inferring its parameters and states by observing its outputs. These properties should be analysed before attempting to calibrate a model.…

Systems and Control · Electrical Eng. & Systems 2022-10-18 Xabier Rey Barreiro , Alejandro F. Villaverde

Medical imaging papers often focus on methodology, but the quality of the algorithms and the validity of the conclusions are highly dependent on the datasets used. As creating datasets requires a lot of effort, researchers often use…

The number of scientific publications continues to rise exponentially, especially in Computer Science (CS). However, current solutions to analyze those publications restrict access behind a paywall, offer no features for visual analysis,…

Digital Libraries · Computer Science 2022-12-02 Lennart Küll

Developing software to undertake complex, compute-intensive scientific processes requires a challenging combination of both specialist domain knowledge and software development skills to convert this knowledge into efficient code. As…

Distributed, Parallel, and Cluster Computing · Computer Science 2013-09-05 Jeremy Cohen , Chris Cantwell , Neil Chue Hong , David Moxey , Malcolm Illingworth , Andrew Turner , John Darlington , Spencer Sherwin

Innovation is slowing greatly in the pharmaceutical sector. It is considered here how part of the problem is due to overly limiting intellectual property relations in the sector. On the other hand, computing and software in particular are…

Computers and Society · Computer Science 2011-06-14 Fionn Murtagh

Software plays a central role in scientific discovery. Improving how we develop and use software for research can have both broad and deep impacts on a spectrum of challenges and opportunities society faces today. The emergence of Research…

Software Engineering · Computer Science 2022-11-17 Michael A. Heroux

The development of scientific software is often a partnership between domain scientists and scientific software engineers. It is especially important to embrace these collaborations when developing advanced scientific software, where…

Software Engineering · Computer Science 2014-07-23 Marcus D. Hanwell , Patrick O'Leary , Bob O'Bara

The rise of software as a research object is mirrored in the increasing interests towards quantitative studies of scientific software. However, due to the inconsistent practice of citing software, most of the existing studies analyzing the…

Digital Libraries · Computer Science 2019-03-01 Kai Li , Pei-Ying Chen , Erjia Yan

Considerable scientific work involves locating, analyzing, systematizing, and synthesizing other publications. Its results end up in a paper's "background" section or in standalone articles, which include meta-analyses and systematic…

Digital Libraries · Computer Science 2023-12-05 Diomidis Spinellis

High-quality research software is a cornerstone of modern scientific progress, enabling researchers to analyze complex data, simulate phenomena, and share reproducible results. However, creating such software requires adherence to best…

Software Engineering · Computer Science 2025-07-23 Nasir U. Eisty , David E. Bernholdt , Alex Koufos , David J. Luet , Miranda Mundt

In the evolving landscape of clinical informatics, the integration and utilization of software tools developed through governmental funding represent a pivotal advancement in research and application. However, the dispersion of these tools…

Digital Libraries · Computer Science 2024-03-28 Jeremy R. Harper

Developers rely on open-source packages and must review dependencies to safeguard against vulnerable or malicious upstream code. A careful review of all dependencies changes often does not occur in practice. Therefore, developers need…

Software Engineering · Computer Science 2025-07-24 Sivana Hamer , Nasif Imtiaz , Mahzabin Tamanna , Preya Shabrina , Laurie Williams

User studies are paramount for advancing science. However, researchers face several barriers when performing them despite the existence of supporting tools. In this work, we study how existing tools and their features cope with previously…

Software Engineering · Computer Science 2025-04-14 Lázaro Costa , Susana Barbosa , Jácome Cunha

Artificial intelligence (AI) techniques are widely applied in the life sciences. However, applying innovative AI techniques to understand and deconvolute biological complexity is hindered by the learning curve for life science scientists to…

Artificial Intelligence · Computer Science 2024-03-28 Nisha Pillai , Athish Ram Das , Moses Ayoola , Ganga Gireesan , Bindu Nanduri , Mahalingam Ramkumar

Critical goals of scientific computing are to increase scientific rigor, reproducibility, and transparency while keeping up with ever-increasing computational demands. This work presents an integrated framework well-suited for data…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-10-13 Paul Nuyujukian

Broad efforts are underway to capture metadata about research software and retain it across services; notable in this regard is the CodeMeta project. What metadata are important to have about (research) software? What metadata are useful…

Instrumentation and Methods for Astrophysics · Physics 2017-12-08 Alice Allen , Peter Teuben , G. Bruce Berriman , Kimberly DuPrie , Keith Shortridge , Rein Warmels

Sustainable software ecosystems are difficult to build, and require concerted effort, community norms and collaborations. In science it is especially important to establish communities in which faculty, staff, students and open-source…

Software Engineering · Computer Science 2013-09-13 Marcus D. Hanwell , Amitha Perera , Wes Turner , Patrick O'Leary , Katie Osterdahl , Bill Hoffman , Will Schroeder

In this chapter we first outline some of the popular computing environments used for analysing neural data, followed by a brief discussion of 'software carpentry', basic tools and skills from software engineering that can be of great use to…

Neurons and Cognition · Quantitative Biology 2012-07-26 Robin A. A. Ince

We provide an overview of the software engineering efforts and their impact in QMCPACK, a production-level ab-initio Quantum Monte Carlo open-source code targeting high-performance computing (HPC) systems. Aspects included are: (i)…

Omics software tools have reshaped the landscape of modern biology and become an essential component of biomedical research. The increasing dependence of biomedical scientists on these powerful tools creates a need for easier installation…

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