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Flow cytometry is a technology that rapidly measures antigen-based markers associated to cells in a cell population. Although analysis of flow cytometry data has traditionally considered one or two markers at a time, there has been…

Applications · Statistics 2010-03-30 Gyemin Lee , William Finn , Clayton Scott

Flow cytometry mainly used for detecting the characteristics of a number of biochemical substances based on the expression of specific markers in cells. It is particularly useful for detecting membrane surface receptors, antigens, ions, or…

Machine Learning · Computer Science 2023-03-17 Yanhua Xu

We present a Bayesian approach for the Contamination Source Detection problem in Water Distribution Networks. Given an observation of contaminants in one or more nodes in the network, we try to give probable explanation for it assuming that…

Data Analysis, Statistics and Probability · Physics 2018-09-28 Ernesto Ortega , Alfredo Braunstein , Alejandro Lage-Castellanos

We consider the use of the Joint Clustering and Matching (JCM) procedure for the supervised classification of a flow cytometric sample with respect to a number of predefined classes of such samples. The JCM procedure has been proposed as a…

Quantitative Methods · Quantitative Biology 2014-11-12 Sharon X. Lee , Geoffrey J. McLachlan , Saumyadipta Pyne

We consider the problem of testing whether two samples of contaminated data, possibly paired, are from the same distribution. Is is assumed that the contaminations are additive noises with known moments of all orders. The test statistic is…

Statistics Theory · Mathematics 2011-05-11 Denys Pommeret

Anomaly detection methods identify examples that do not follow the expected behaviour, typically in an unsupervised fashion, by assigning real-valued anomaly scores to the examples based on various heuristics. These scores need to be…

Machine Learning · Computer Science 2023-10-19 Lorenzo Perini , Paul Buerkner , Arto Klami

We study the inference of the origin and the pattern of contamination in water distribution networks. We assume a simplified model for the dyanmics of the contamination spread inside a water distribution network, and assume that at some…

Physics and Society · Physics 2017-12-07 Alfredo Braunstein , Alejandro Lage-Castellanos , Ernesto Ortega

Background: Trace quantities of contaminating DNA are widespread in the laboratory environment, but their presence has received little attention in the context of high throughput sequencing. This issue is highlighted by recent works that…

Genomics · Quantitative Biology 2015-06-18 Richard W Lusk

CDD, or Contamination Detection via output Distribution, identifies data contamination by measuring the peakedness of a model's sampled outputs. We study the conditions under which this approach succeeds and fails on small language models…

Artificial Intelligence · Computer Science 2026-03-12 Omer Sela

Flow cytometry is a powerful quantitative assay supporting high-throughput collection of single-cell data with a high dynamic range. For flow cytometry to yield reproducible data with a quantitative relationship to the underlying biology,…

Quantitative Methods · Quantitative Biology 2023-05-16 Jacob Beal

Flow cytometry is a technique that measures multiple fluorescence and light scatter-associated parameters from individual cells as they flow a single file through an excitation light source. These cells are labeled with antibodies to detect…

Conformal prediction is a flexible framework for calibrating machine learning predictions, providing distribution-free statistical guarantees. In outlier detection, this calibration relies on a reference set of labeled inlier data to…

Machine Learning · Statistics 2025-06-17 Meshi Bashari , Matteo Sesia , Yaniv Romano

Specimens are collected from $N$ different sources. Each specimen has probability $p$ of being contaminated (e.g., in the case of an infectious disease, $p$ is the prevalence rate), independently of the other specimens. In many cases group…

Probability · Mathematics 2024-01-31 Vassilis G. Papanicolaou

Circulating blood cell clusters (CCCs) containing red blood cells (RBCs), white blood cells(WBCs), and platelets are significant biomarkers linked to conditions like thrombosis, infection, and inflammation. Flow cytometry, paired with…

Computer Vision and Pattern Recognition · Computer Science 2025-10-21 Suqiang Ma , Subhadeep Sengupta , Yao Lee , Beikang Gu , Xianyan Chen , Xianqiao Wang , Yang Liu , Mengjia Xu , Galit H. Frydman , He Li

While previous distribution shift detection approaches can identify if a shift has occurred, these approaches cannot localize which specific features have caused a distribution shift -- a critical step in diagnosing or fixing any underlying…

Machine Learning · Computer Science 2021-07-16 Sean Kulinski , Saurabh Bagchi , David I. Inouye

In data analysis, contamination caused by outliers is inevitable, and robust statistical methods are strongly demanded. In this paper, our concern is to develop a new approach for robust data analysis based on scoring rules. The scoring…

Statistics Theory · Mathematics 2013-11-22 Takafumi Kanamori , Hironori Fujisawa

The ocean is filled with phytoplankton that contribute as much photosynthesis as all land plants combined, making them vital to the carbon cycle and climate system. Recent advances in flow cytometry allow oceanographers to measure the…

Methodology · Statistics 2026-03-09 Yik Lun Kei , Qi Wang , Paul Parker , Francois Ribalet , Sangwon Hyun

With the rise of machine learning and deep learning based applications in practice, monitoring, i.e. verifying that these operate within specification, has become an important practical problem. An important aspect of this monitoring is to…

Machine Learning · Computer Science 2021-06-29 Thomas Viehmann

Large language models (LLMs) are widely used, but concerns about data contamination challenge the reliability of LLM evaluations. Existing contamination detection methods are often task-specific or require extra prerequisites, limiting…

Computation and Language · Computer Science 2024-10-22 Yi Zhao , Jing Li , Linyi Yang

In this paper, we advocate a novel measure for the purpose of checking the quality of a cluster partition for a sample into several distinct classes, and thus, determine the unknown value for the true number of clusters prevailing the…

Applications · Statistics 2024-04-12 Soumita Modak
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