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Interpretability of deep learning is widely used to evaluate the reliability of medical imaging models and reduce the risks of inaccurate patient recommendations. For models exceeding human performance, e.g. predicting RNA structure from…

Quantitative Methods · Quantitative Biology 2022-08-31 Mara Graziani , Niccolò Marini , Nicolas Deutschmann , Nikita Janakarajan , Henning Müller , María Rodríguez Martínez

Continual learning aims to update models under distribution shift without forgetting, yet many high-stakes deployments, such as healthcare, also require interpretability. In practice, models that adapt well (e.g., deep networks) are often…

Machine Learning · Computer Science 2026-04-21 Dongkyu Cho , Xiyue Li , Samrachana Adhikari , Rumi Chunara

Skin cancer is a frequently occurring cancer in the human population, and it is very important to be able to diagnose malignant tumors in the body early. Lesion segmentation is crucial for monitoring the morphological changes of skin…

Image and Video Processing · Electrical Eng. & Systems 2023-09-06 Changlu Guo , Jiangyan Dai , Marton Szemenyei , Yugen Yi

Recent advancements in artificial intelligence (AI) have facilitated its widespread adoption in primary medical services, addressing the demand-supply imbalance in healthcare. Vision Transformers (ViT) have emerged as state-of-the-art…

Computer Vision and Pattern Recognition · Computer Science 2023-09-04 Tin Lai

Deep neural networks have achieved remarkable success in computer vision; however, their black-box nature in decision-making limits interpretability and trust, particularly in safety-critical applications. Interpretability is crucial in…

Computer Vision and Pattern Recognition · Computer Science 2025-10-07 Ran Eisenberg , Amit Rozner , Ethan Fetaya , Ofir Lindenbaum

Nearly one in five adolescents currently live with a diagnosed mental or behavioral health condition, such as anxiety, depression, or conduct disorder, underscoring the urgency of developing accurate and interpretable diagnostic tools.…

Machine Learning · Computer Science 2025-10-07 Song Wang , Zhenyu Lei , Zhen Tan , Jundong Li , Javier Rasero , Aiying Zhang , Chirag Agarwal

Convolutional Neural Networks (CNNs) have shown remarkable progress in medical image segmentation. However, lesion segmentation remains a challenge to state-of-the-art CNN-based algorithms due to the variance in scales and shapes. On the…

Image and Video Processing · Electrical Eng. & Systems 2023-05-31 Yanwen Li , Luyang Luo , Huangjing Lin , Pheng-Ann Heng , Hao Chen

As an emerging interpretable technique, Generalized Additive Models (GAMs) adopt neural networks to individually learn non-linear functions for each feature, which are then combined through a linear model for final predictions. Although…

Machine Learning · Computer Science 2024-08-01 Viet Duong , Qiong Wu , Zhengyi Zhou , Hongjue Zhao , Chenxiang Luo , Eric Zavesky , Huaxiu Yao , Huajie Shao

Deep learning models show significant potential for advancing AI-assisted medical diagnostics, particularly in detecting lung cancer through medical image modalities such as chest X-rays. However, the black-box nature of these models poses…

Machine Learning · Computer Science 2025-03-31 Amy Rafferty , Rishi Ramaesh , Ajitha Rajan

Machine learning models that first learn a representation of a domain in terms of human-understandable concepts, then use it to make predictions, have been proposed to facilitate interpretation and interaction with models trained on…

Machine Learning · Computer Science 2020-12-08 Isaac Lage , Finale Doshi-Velez

Deep Neural Networks have often been called the black box because of the complex, deep architecture and non-transparency presented by the inner layers. There is a lack of trust to use Artificial Intelligence in critical and high-precision…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Frincy Clement , Ji Yang , Irene Cheng

Artificial Intelligence has emerged as a useful aid in numerous clinical applications for diagnosis and treatment decisions. Deep neural networks have shown same or better performance than clinicians in many tasks owing to the rapid…

Image and Video Processing · Electrical Eng. & Systems 2021-11-05 Zohaib Salahuddin , Henry C Woodruff , Avishek Chatterjee , Philippe Lambin

As interpretability has been pointed out as the obstacle to the adoption of Deep Neural Networks (DNNs), there is an increasing interest in solving a transparency issue to guarantee the impressive performance. In this paper, we demonstrate…

Image and Video Processing · Electrical Eng. & Systems 2021-07-20 Woo-Jeoung Nam , Seong-Whan Lee

Explaining the decisions of Deep Neural Networks (DNNs) for medical images has become increasingly important. Existing attribution methods have difficulty explaining the meaning of pixels while existing concept-based methods are limited by…

Artificial Intelligence · Computer Science 2024-08-20 Weiji Kong , Xun Gong , Juan Wang

Convolutional Neural Networks (CNNs) have seen significant performance improvements in recent years. However, due to their size and complexity, they function as black-boxes, leading to transparency concerns. State-of-the-art saliency…

Computer Vision and Pattern Recognition · Computer Science 2025-06-04 Antonio De Santis , Riccardo Campi , Matteo Bianchi , Marco Brambilla

Trustworthy artificial intelligence (AI) is essential in healthcare, particularly for high-stakes tasks like medical image segmentation. Explainable AI and uncertainty quantification significantly enhance AI reliability by addressing key…

In recent years, the incidence of vision-threatening eye diseases has risen dramatically, necessitating scalable and accurate screening solutions. This paper presents a comprehensive study on deep learning architectures for the automated…

Computer Vision and Pattern Recognition · Computer Science 2025-12-12 Mohammad Sadegh Gholizadeh , Amir Arsalan Rezapour

Melanoma is amongst most aggressive types of cancer. However, it is highly curable if detected in its early stages. Prescreening of suspicious moles and lesions for malignancy is of great importance. Detection can be done by images captured…

Computer Vision and Pattern Recognition · Computer Science 2017-03-29 Mohammad H. Jafari , Ebrahim Nasr-Esfahani , Nader Karimi , S. M. Reza Soroushmehr , Shadrokh Samavi , Kayvan Najarian

Deep neural networks have been widely adopted in numerous domains due to their high performance and accessibility to developers and application-specific end-users. Fundamental to image-based applications is the development of Convolutional…

Computer Vision and Pattern Recognition · Computer Science 2023-12-20 Emily Kaczmarek , Olivier X. Miguel , Alexa C. Bowie , Robin Ducharme , Alysha L. J. Dingwall-Harvey , Steven Hawken , Christine M. Armour , Mark C. Walker , Kevin Dick

Deep learning has played a major role in the interpretation of dermoscopic images for detecting skin defects and abnormalities. However, current deep learning solutions for dermatological lesion analysis are typically limited in providing…

Computer Vision and Pattern Recognition · Computer Science 2021-07-20 Gun-Hee Lee , Han-Bin Ko , Seong-Whan Lee