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Being able to learn on weakly labeled data, and provide interpretability, are two of the main reasons why attention-based deep multiple instance learning (ABMIL) methods have become particularly popular for classification of…

Computer Vision and Pattern Recognition · Computer Science 2022-03-09 Axel Andersson , Nadezhda Koriakina , Nataša Sladoje , Joakim Lindblad

Weakly-supervised video anomaly detection (WS-VAD) using Multiple Instance Learning (MIL) suffers from label ambiguity, hindering discriminative feature learning. We propose ProDisc-VAD, an efficient framework tackling this via two…

Computer Vision and Pattern Recognition · Computer Science 2025-07-18 Tao Zhu , Qi Yu , Xinru Dong , Shiyu Li , Yue Liu , Jinlong Jiang , Lei Shu

Alzheimer's Disease (AD) is the most common neurodegenerative disorder with one of the most complex pathogeneses, making effective and clinically actionable decision support difficult. The objective of this study was to develop a novel…

Machine Learning · Computer Science 2022-09-27 Michal Golovanevsky , Carsten Eickhoff , Ritambhara Singh

Developing self-supervised learning (SSL) models that can learn universal and transferable representations of H&E gigapixel whole-slide images (WSIs) is becoming increasingly valuable in computational pathology. These models hold the…

Image and Video Processing · Electrical Eng. & Systems 2024-08-07 Guillaume Jaume , Anurag Vaidya , Andrew Zhang , Andrew H. Song , Richard J. Chen , Sharifa Sahai , Dandan Mo , Emilio Madrigal , Long Phi Le , Faisal Mahmood

Supervised learning tasks such as cancer survival prediction from gigapixel whole slide images (WSIs) are a critical challenge in computational pathology that requires modeling complex features of the tumor microenvironment. These learning…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 Iain Carmichael , Andrew H. Song , Richard J. Chen , Drew F. K. Williamson , Tiffany Y. Chen , Faisal Mahmood

Multiple Instance Learning (MIL) has emerged as a dominant paradigm to extract discriminative feature representations within Whole Slide Images (WSIs) in computational pathology. Despite driving notable progress, existing MIL approaches…

Computer Vision and Pattern Recognition · Computer Science 2024-03-12 Shu Yang , Yihui Wang , Hao Chen

Multiple instance learning (MIL) has enabled substantial progress in computational histopathology, where a large amount of patches from gigapixel whole slide images are aggregated into slide-level predictions. Heatmaps are widely used to…

Multiple instance learning (MIL) is the preferred approach for whole slide image classification. However, most MIL approaches do not exploit the interdependencies of tiles extracted from a whole slide image, which could provide valuable…

Computer Vision and Pattern Recognition · Computer Science 2021-08-26 Marvin Lerousseau , Maria Vakalopoulou , Eric Deutsch , Nikos Paragios

Computer-aided pathology diagnosis based on the classification of Whole Slide Image (WSI) plays an important role in clinical practice, and it is often formulated as a weakly-supervised Multiple Instance Learning (MIL) problem. Existing…

Computer Vision and Pattern Recognition · Computer Science 2022-10-11 Linhao Qu , Xiaoyuan Luo , Manning Wang , Zhijian Song

The visual examination of tissue biopsy sections is fundamental for cancer diagnosis, with pathologists analyzing sections at multiple magnifications to discern tumor cells and their subtypes. However, existing attention-based multiple…

Computer Vision and Pattern Recognition · Computer Science 2024-10-11 Olga Fourkioti , Matt De Vries , Chen Jin , Daniel C. Alexander , Chris Bakal

Pathological image analysis is an important process for detecting abnormalities such as cancer from cell images. However, since the image size is generally very large, the cost of providing detailed annotations is high, which makes it…

Computer Vision and Pattern Recognition · Computer Science 2023-04-10 Shusuke Takahama , Yusuke Kurose , Yusuke Mukuta , Hiroyuki Abe , Akihiko Yoshizawa , Tetsuo Ushiku , Masashi Fukayama , Masanobu Kitagawa , Masaru Kitsuregawa , Tatsuya Harada

Multiple Instance Learning (MIL) has been widely used in weakly supervised whole slide image (WSI) classification. Typical MIL methods include a feature embedding part, which embeds the instances into features via a pre-trained feature…

Computer Vision and Pattern Recognition · Computer Science 2024-08-02 Peijie Qiu , Pan Xiao , Wenhui Zhu , Yalin Wang , Aristeidis Sotiras

Multiple instance learning (MIL) is a framework for weakly supervised classification, where labels are assigned to sets of instances, i.e., bags, rather than to individual data points. This paradigm has proven effective in tasks where…

Machine Learning · Computer Science 2026-03-03 Salome Kazeminia , Carsten Marr , Bastian Rieck

The classification of gigapixel histopathology images with deep multiple instance learning models has become a critical task in digital pathology and precision medicine. In this work, we propose a Transformer-based multiple instance…

Computer Vision and Pattern Recognition · Computer Science 2023-11-21 Josef Cersovsky , Sadegh Mohammadi , Dagmar Kainmueller , Johannes Hoehne

Whole body magnetic resonance imaging (WB-MRI) is the recommended modality for diagnosis of multiple myeloma (MM). WB-MRI is used to detect sites of disease across the entire skeletal system, but it requires significant expertise and is…

Multiple Instance Learning (MIL) effectively analyzes whole slide images but faces overfitting due to attention over-concentration. While existing solutions rely on complex architectural modifications or additional processing steps, we…

Computer Vision and Pattern Recognition · Computer Science 2025-07-01 Yunlong Zhang , Honglin Li , Yunxuan Sun , Zhongyi Shui , Jingxiong Li , Chenglu Zhu , Lin Yang

Though multiple instance learning (MIL) has been a foundational strategy in computational pathology for processing whole slide images (WSIs), current approaches are designed for traditional hematoxylin and eosin (H&E) slides rather than…

Image and Video Processing · Electrical Eng. & Systems 2024-11-15 Marc Harary , Eliezer M. Van Allen , William Lotter

Objective: We develop a computer-aided diagnosis (CAD) system using deep learning approaches for lesion detection and classification on whole-slide images (WSIs) with breast cancer. The deep features being distinguishing in classification…

Image and Video Processing · Electrical Eng. & Systems 2021-08-29 Wei-Wen Hsu , Yongfang Wu , Chang Hao , Yu-Ling Hou , Xiang Gao , Yun Shao , Xueli Zhang , Tao He , Yanhong Tai

Cancer survival prediction is a challenging task that involves analyzing of the tumor microenvironment within Whole Slide Image (WSI). Previous methods cannot effectively capture the intricate interaction features among instances within the…

Computer Vision and Pattern Recognition · Computer Science 2024-10-23 Zekang Yang , Hong Liu , Xiangdong Wang

Whole Slide Imaging (WSI), which involves high-resolution digital scans of pathology slides, has become the gold standard for cancer diagnosis, but its gigapixel resolution and the scarcity of annotated datasets present challenges for deep…

Image and Video Processing · Electrical Eng. & Systems 2025-02-03 Rita Pereira , M. Rita Verdelho , Catarina Barata , Carlos Santiago