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For toxicology studies, the validation of the concurrent control group by historical control data (HCD) has become requirements. This validation is usually done by historical control limits (HCL), which should cover the observations of the…

Applications · Statistics 2025-07-18 Max Menssen , Jonathan Rathjens

In pharmaceutical and toxicological research, historical control data are increasingly used to validate concurrent control groups, typically via the construction of historical control limits. While methods have been described for continuous…

Methodology · Statistics 2026-03-24 Sören Budig , Frank Schaarschmidt , Max Menssen

A prediction interval is a statistical interval that should encompass one (or more) future observation(s) with a given coverage probability and is usually computed based on historical control data. The application of prediction intervals is…

Applications · Statistics 2022-09-08 Max Menssen

In assessing prediction accuracy of multivariable prediction models, optimism corrections are essential for preventing biased results. However, in most published papers of clinical prediction models, the point estimates of the prediction…

Overdispersed count data are modelled with likelihood and non-likelihood approaches. Likelihood approaches include the Poisson mixtures with three distributions, the gamma, the lognormal, and the inverse Gaussian distributions.…

Methodology · Statistics 2008-09-08 Stanley Xu , Gary Grunwald , Richard Jones

We propose and analyze a model-based bootstrap for transition kernels in finite controlled Markov chains (CMCs) with possibly nonstationary or history-dependent control policies, a setting that arises naturally in offline reinforcement…

Machine Learning · Statistics 2026-05-13 Ziwei Su , Imon Banerjee , Diego Klabjan

The premise of independence among subjects in the same cluster/group often fails in practice, and models that rely on such untenable assumption can produce misleading results. To overcome this severe deficiency, we introduce a new…

Methodology · Statistics 2022-02-22 Jussiane Nader Gonçalves , Wagner Barreto-Souza , Hernando Ombao

The Bell regression model (BRM) is a statistical model that is often used in the analysis of count data that exhibits overdispersion. In this study, we propose a Bayesian analysis of the BRM and offer a new perspective on its application.…

Computation · Statistics 2024-03-13 Ameer Musa Imran Alhseeni , Hossein Bevrani

We develop and implement a novel fast bootstrap for dependent data. Our scheme is based on the i.i.d. resampling of the smoothed moment indicators. We characterize the class of parametric and semi-parametric estimation problems for which…

Methodology · Statistics 2022-01-19 Davide La Vecchia , Alban Moor , Olivier Scaillet

In a regression model, prediction is typically performed after model selection. The large variability in the model selection makes the prediction unstable. Thus, it is essential to reduce the variability in model selection and improve…

Computation · Statistics 2024-04-11 Wataru Yoshida , Kei Hirose

This paper presents a new method to estimate systematic errors in the maximum-likelihood regression of count data. The method is applicable in particular to X-ray spectra in situations where the Poisson log-likelihood, or the Cash…

Instrumentation and Methods for Astrophysics · Physics 2023-05-03 M. Bonamente

Multiple systems estimation using a Poisson loglinear model is a standard approach to quantifying hidden populations where data sources are based on lists of known cases. Information criteria are often used for selecting between the large…

Methodology · Statistics 2023-11-23 Bernard W. Silverman , Lax Chan , Kyle Vincent

Prediction intervals are commonly used in meta-analysis with random-effects models. One widely used method, the Higgins-Thompson-Spiegelhalter prediction interval, replaces the heterogeneity parameter with its point estimate, but its…

Methodology · Statistics 2025-11-14 Kengo Nagashima , Hisashi Noma , Toshi A. Furukawa

This study introduces a predictive maintenance strategy for high pressure industrial compressors using sensor data and features derived from unsupervised clustering integrated into classification models. The goal is to enhance model…

Machine Learning · Computer Science 2024-11-22 Alessandro Costa , Emilio Mastriani , Federico Incardona , Kevin Munari , Sebastiano Spinello

We introduce a class of concurrent learning (CL) algorithms designed to solve parameter estimation problems with convergence rates ranging from hyperexponential to prescribed-time while utilizing alternating datasets during the learning…

Optimization and Control · Mathematics 2025-02-28 Daniel E. Ochoa , Jorge I. Poveda

Clustered data arise naturally in many scientific and applied research settings where units are grouped within clusters. They are commonly analyzed using linear mixed models to account for within-cluster correlations. This article focuses…

Methodology · Statistics 2025-10-10 Zhi Yang Tho , Raymond Chambers , A. H. Welsh

This paper deals with phase II, univariate, statistical process control when a set of in-control data is available, and when both the in-control and out-of-control distributions of the process are unknown. Existing process control…

Applications · Statistics 2009-06-09 Snigdhansu Chatterjee , Peihua Qiu

A software tool, computing observed and expected upper limits on Poissonian process rates using a hybrid frequentist-Bayesian CLs method, is presented. This tool can be used for simple counting experiments where only signal, background and…

High Energy Physics - Experiment · Physics 2018-03-26 Emmanuel Busato , David Calvet , Timothée Theveneaux-Pelzer

Blinded sample size re-estimation and information monitoring based on blinded data has been suggested to mitigate risks due to planning uncertainties regarding nuisance parameters. Motivated by a randomized controlled trial in pediatric…

Applications · Statistics 2019-03-07 Tobias Mütze , Susanna Salem , Norbert Benda , Heinz Schmidli , Tim Friede

A prediction interval covers a future observation from a random process in repeated sampling, and is typically constructed by identifying a pivotal quantity that is also an ancillary statistic. Analogously, a tolerance interval covers a…

Methodology · Statistics 2022-01-19 Geoffrey S Johnson
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