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The integration of deep learning systems into healthcare has been hindered by the resource-intensive process of data annotation and the inability of these systems to generalize to different data distributions. Foundation models, which are…

Computer Vision and Pattern Recognition · Computer Science 2024-09-17 Mohammed Baharoon , Waseem Qureshi , Jiahong Ouyang , Yanwu Xu , Abdulrhman Aljouie , Wei Peng

The deep learning field is converging towards the use of general foundation models that can be easily adapted for diverse tasks. While this paradigm shift has become common practice within the field of natural language processing, progress…

Computer Vision and Pattern Recognition · Computer Science 2023-11-15 Joana Palés Huix , Adithya Raju Ganeshan , Johan Fredin Haslum , Magnus Söderberg , Christos Matsoukas , Kevin Smith

Vision foundation models like DINOv2 demonstrate remarkable potential in medical imaging despite their origin in natural image domains. However, their design inherently works best for uni-modal image analysis, limiting their effectiveness…

Image and Video Processing · Electrical Eng. & Systems 2025-09-09 Daniel Scholz , Ayhan Can Erdur , Viktoria Ehm , Anke Meyer-Baese , Jan C. Peeken , Daniel Rueckert , Benedikt Wiestler

Peripheral blood smears remain a cornerstone in the diagnosis of hematological neoplasms, offering rapid and valuable insights that inform subsequent diagnostic steps. However, since neoplastic transformations typically arise in the bone…

Diffusion models (DMs) have emerged as powerful foundation models for a variety of tasks, with a large focus in synthetic image generation. However, their requirement of large annotated datasets for training limits their applicability in…

Computer Vision and Pattern Recognition · Computer Science 2024-07-17 Guillermo Jimenez-Perez , Pedro Osorio , Josef Cersovsky , Javier Montalt-Tordera , Jens Hooge , Steffen Vogler , Sadegh Mohammadi

Recent breakthroughs in self-supervised learning have enabled the use of large unlabeled datasets to train visual foundation models that can generalize to a variety of downstream tasks. While this training paradigm is well suited for the…

Microscopic evaluation of white blood cell morphology is central to leukemia diagnosis, yet current deep learning models often act as black boxes, limiting clinical trust and adoption. We introduce HemBLIP, a vision language model designed…

Computer Vision and Pattern Recognition · Computer Science 2026-01-08 Julie van Logtestijn , Petru Manescu

Cytology is essential for cancer diagnostics and screening due to its minimally invasive nature. However, the development of robust deep learning models for digital cytology is challenging due to the heterogeneity in staining and…

Computer Vision and Pattern Recognition · Computer Science 2025-04-21 Vedrana Ivezić , Ashwath Radhachandran , Ekaterina Redekop , Shreeram Athreya , Dongwoo Lee , Vivek Sant , Corey Arnold , William Speier

Digital hematopathology requires cell-level analysis across diverse disease categories, including malignant disorders (e.g., leukemia), infectious conditions (e.g., malaria), and non-malignant red blood cell disorders (e.g., sickle cell…

Computer Vision and Pattern Recognition · Computer Science 2025-11-20 Abdul Rehman , Iqra Rasool , Ayisha Imran , Mohsen Ali , Waqas Sultani

Medical image analysis frequently encounters data scarcity challenges. Transfer learning has been effective in addressing this issue while conserving computational resources. The recent advent of foundational models like the DINOv2, which…

Image and Video Processing · Electrical Eng. & Systems 2024-02-14 Yuning Huang , Jingchen Zou , Lanxi Meng , Xin Yue , Qing Zhao , Jianqiang Li , Changwei Song , Gabriel Jimenez , Shaowu Li , Guanghui Fu

Diagnosing and treating skin diseases require advanced visual skills across domains and the ability to synthesize information from multiple imaging modalities. While current deep learning models excel at specific tasks like skin cancer…

Automating white blood cell classification for diagnosis of leukaemia is a promising alternative to time-consuming and resource-intensive examination of cells by expert pathologists. However, designing robust algorithms for classification…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Siddharth Srivastava , Adam Smith , Scott Brooks , Jack Bacon , Till Bretschneider

The application of machine learning techniques to the medical domain is especially challenging due to the required level of precision and the incurrence of huge risks of minute errors. Employing these techniques to a more complex subdomain…

Computer Vision and Pattern Recognition · Computer Science 2021-10-19 Ekta Gavas , Kaustubh Olpadkar

Bone marrow cell cytomorphology analysis is critical for the diagnosis of hematological malignancies but remains a labor-intensive process subject to significant inter-observer variability. While recent foundation models have shown promise…

Other Quantitative Biology · Quantitative Biology 2025-12-23 Aziz Muminov , Anne Pham

The classification of white blood cells (WBCs) from peripheral blood smears is critical for the diagnosis of leukemia. However, automated approaches still struggle due to challenges including class imbalance, domain shift, and morphological…

Computer Vision and Pattern Recognition · Computer Science 2026-03-24 Antony Gitau , Martin Paulson , Bjørn-Jostein Singstad , Karl Thomas Hjelmervik , Ola Marius Lysaker , Veralia Gabriela Sanchez

Foundation models are reshaping computational pathology by enabling transfer learning, where models pre-trained on vast datasets can be adapted for downstream diagnostic, prognostic, and therapeutic response tasks. Despite these advances,…

Foundation models in artificial intelligence (AI) are transforming medical imaging by enabling general-purpose feature learning from large-scale, unlabeled datasets. In this work, we introduce BrainFound, a self-supervised foundation model…

Computer Vision and Pattern Recognition · Computer Science 2026-01-01 Moona Mazher , Geoff J. M. Parker , Daniel C. Alexander

Timely and accurate lymphoma diagnosis is essential for guiding cancer treatment. Standard diagnostic practice combines hematoxylin and eosin (HE)-stained whole slide images with immunohistochemistry, flow cytometry, and molecular genetic…

The use of artificial intelligence to enable precision medicine and decision support systems through the analysis of pathology images has the potential to revolutionize the diagnosis and treatment of cancer. Such applications will depend on…

Accurate morphological classification of white blood cells (WBCs) is an important step in the diagnosis of leukemia, a disease in which nonfunctional blast cells accumulate in the bone marrow. Recently, deep convolutional neural networks…

Computer Vision and Pattern Recognition · Computer Science 2023-04-19 Rao Muhammad Umer , Armin Gruber , Sayedali Shetab Boushehri , Christian Metak , Carsten Marr
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