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Critical decision-making issues in science, engineering, and industry are based on combinatorial optimization; however, its application is inherently limited by the NP-hard nature of the problem. A specialized paradigm of analogue quantum…

Quantum Physics · Physics 2026-02-04 Rudraksh Sharma , Ravi Katukam , Arjun Nagulapally

A challenge for scalability of demand-responsive, elastic optical Dense Wavelength Division Multiplexing (DWDM) and Flexgrid networks is the computational complexity of allocating many optical routes on large networks. We demonstrate that…

Networking and Internet Architecture · Computer Science 2024-02-13 Ethan Davies , Darren Banfield , Vlad Carare , Ben Weaver , Catherine White , Nigel Walker

We extend the family of problems that may be implemented on an adiabatic quantum optimizer (AQO). When a quadratic optimization problem has at least one set of discrete controls and the constraints are linear, we call this a quadratic…

Quantum Physics · Physics 2014-07-16 Rishabh Chandra , N. Tobias Jacobson , Jonathan E. Moussa , Steven H. Frankel , Sabre Kais

Quadratic unconstrained binary optimization (QUBO) is the mathematical formalism for phrasing and solving a class of optimization problems that are combinatorial in nature. Due to their natural equivalence with the two dimensional Ising…

Feature selection is a machine learning technique for identifying relevant variables in classification and regression models. In single-cell RNA sequencing (scRNA-seq) data analysis, feature selection is used to identify relevant genes that…

Genomics · Quantitative Biology 2025-12-02 Selim Romero , Shreyan Gupta , Victoria Gatlin , Robert S. Chapkin , James J. Cai

Quantum Approximate Optimization Algorithm (QAOA) and Quantum Annealing are prominent approaches for solving combinatorial optimization problems, such as those formulated as Quadratic Unconstrained Binary Optimization (QUBO). These…

Formulation symmetry in mixed-integer programming (MIP) can hinder solver performance by inducing redundant search, but detecting such symmetries is also a significant computational challenge. This paper explores the potential for quantum…

Optimization and Control · Mathematics 2025-12-18 Alexander While , Chen Chen

Abstraction layers are of paramount importance in software architecture, as they shield the higher-level formulation of payload computations from lower-level details. Since quantum computing (QC) introduces many such details that are often…

Quantum Physics · Physics 2024-09-04 Lukas Schmidbauer , Karen Wintersperger , Elisabeth Lobe , Wolfgang Mauerer

In this paper, we present a new method to solve a certain type of Semidefinite Programming (SDP) problems. These types of SDPs naturally arise in the Quadratic Convex Reformulation (QCR) method and can be used to obtain dual bounds of…

Optimization and Control · Mathematics 2023-12-27 Apostolos Chalkis , Thomas Kleinert , Boro Sofranac

The broad applicability of Quadratic Unconstrained Binary Optimization (QUBO) constitutes a general-purpose modeling framework for combinatorial optimization problems and are a required format for gate array and quantum annealing computers.…

Artificial Intelligence · Computer Science 2021-04-06 Amit Verma , Mark Lewis

Leveraging quantum computers for optimization problems holds promise across various application domains. Nevertheless, utilizing respective quantum computing solvers requires describing the optimization problem according to the Quadratic…

Quantum Physics · Physics 2025-10-15 Deborah Volpe , Nils Quetschlich , Mariagrazia Graziano , Giovanna Turvani , Robert Wille

Today, hardware constraints are an important limitation on quantum adiabatic optimization algorithms. Firstly, computational problems must be formulated as quadratic unconstrained binary optimization (QUBO) in the presence of noisy coupling…

Quantum Physics · Physics 2018-12-06 Andrew Lucas

In finance, assessing the creditworthiness of loan applicants requires lenders to cluster borrowers using rating scales. Financial institutions must define the scales in compliance with strict institutional constraints, resulting in solving…

I present a novel use of quantum annealing to solve the Set Splitting Problem using (QUBO) problem formulation. The contribution of the work is in formulating penalty functions that ensure the ground state of the QUBO Hamiltonian…

Quantum Physics · Physics 2025-08-11 Sean Borneman

Variational quantum circuits for image classification suffer from barren plateaus, while quantum kernel methods scale quadratically with dataset size. We propose an iterative framework based on Quadratic Unconstrained Binary Optimization…

Quantum Physics · Physics 2026-03-04 Mostafa Atallah , Rebekah Herrman

Quantum annealing aims at solving optimization problems of practical relevance using quantum-computing hardware. Problems of interest are typically formulated in terms of quadratic unconstrained binary optimization (QUBO) Hamiltonians.…

Many artificial intelligence (AI) problems naturally map to NP-hard optimization problems. This has the interesting consequence that enabling human-level capability in machines often requires systems that can handle formally intractable…

Quantum Physics · Physics 2009-09-29 Hartmut Neven , Geordie Rose , William G. Macready

In this paper, we develop a way to encode several NP-Complete problems in Abstract Argumentation to Quadratic Unconstrained Binary Optimization (QUBO) problems. In this form, a solution for a QUBO problem involves minimizing a quadratic…

Quantum Physics · Physics 2024-09-10 Marco Baioletti , Francesco Santini

Training machine learning models on classical computers is usually a time and compute intensive process. With Moore's law coming to an end and ever increasing demand for large-scale data analysis using machine learning, we must leverage…

Machine Learning · Computer Science 2021-11-16 Prasanna Date , Davis Arthur , Lauren Pusey-Nazzaro

Quantum annealers offer a promising hardware platform for solving combinatorial optimization problems, especially those formulated as Quadratic Unconstrained Binary Optimization (QUBO). In this work, we propose PDQUBO (Performance-Driven…

Information Retrieval · Computer Science 2026-05-01 Jiayang Niu , Jie Li , Ke Deng , Mark Sanderson , Nicola Ferro , Yongli Ren