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Natural language processing (NLP) models trained on people-generated data can be unreliable because, without any constraints, they can learn from spurious correlations that are not relevant to the task. We hypothesize that enriching models…
Cognitive decline is a natural part of aging. However, under some circumstances, this decline is more pronounced than expected, typically due to disorders such as Alzheimer's disease. Early detection of an anomalous decline is crucial, as…
Advances in variational inference enable parameterisation of probabilistic models by deep neural networks. This combines the statistical transparency of the probabilistic modelling framework with the representational power of deep learning.…
Automated discourse analysis tools based on Natural Language Processing (NLP) aiming at the diagnosis of language-impairing dementias generally extract several textual metrics of narrative transcripts. However, the absence of sentence…
The validity of medical studies based on real-world clinical data, such as observational studies, depends on critical assumptions necessary for drawing causal conclusions about medical interventions. Many published studies are flawed…
The increasing capture and analysis of large-scale longitudinal health data offer opportunities to improve healthcare and advance medical understanding. However, a critical gap exists between (a) -- the observation of patterns and…
When people interpret text, they rely on inferences that go beyond the observed language itself. Inspired by this observation, we introduce a method for the analysis of text that takes implicitly communicated content explicitly into…
Explaining deep learning models is essential for clinical integration of medical image analysis systems. A good explanation highlights if a model depends on spurious features that undermines generalization and harms a subset of patients or,…
Follow-up conversations with virtual assistants (VAs) enable a user to seamlessly interact with a VA without the need to repeatedly invoke it using a keyword (after the first query). Therefore, accurate Device-directed Speech Detection…
Patient-generated text such as secure messages, surveys, and interviews contains rich expressions of the patient voice (PV), reflecting communicative behaviors and social determinants of health (SDoH). Traditional qualitative coding…
Experimental methods for estimating the impacts of text on human evaluation have been widely used in the social sciences. However, researchers in experimental settings are usually limited to testing a small number of pre-specified text…
Clinical reasoning in medicine is a hypothesis-driven process where physicians refine diagnoses from limited information through targeted history, physical examination, and diagnostic investigations. In contrast, current medical benchmarks…
Natural Language Processing (NLP) systems often make use of machine learning techniques that are unfamiliar to end-users who are interested in analyzing clinical records. Although NLP has been widely used in extracting information from…
Systematic use of the published results of randomized clinical trials is increasingly important in evidence-based medicine. In order to collate and analyze the results from potentially numerous trials, evidence tables are used to represent…
We present PPI++: a computationally lightweight methodology for estimation and inference based on a small labeled dataset and a typically much larger dataset of machine-learning predictions. The methods automatically adapt to the quality of…
Instrumental variable methods provide useful tools for inferring causal effects in the presence of unmeasured confounding. To apply these methods with large-scale data sets, a major challenge is to find valid instruments from a possibly…
We develop methodology for valid inference after variable selection in logistic regression when the responses are partially observed, that is, when one observes a set of error-prone testing outcomes instead of the true values of the…
Passively collected behavioral health data from ubiquitous sensors holds significant promise to provide mental health professionals insights from patient's daily lives; however, developing analysis tools to use this data in clinical…
Background: Before being used to inform patient care, a risk prediction model needs to be validated in a representative sample from the target population. The finite size of the validation sample entails that there is uncertainty with…
Research Replication Prediction (RRP) is the task of predicting whether a published research result can be replicated or not. Building an interpretable neural text classifier for RRP promotes the understanding of why a research paper is…