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This paper introduces an innovative Electronic Health Record (EHR) foundation model that integrates Polygenic Risk Scores (PRS) as a foundational data modality, moving beyond traditional EHR-only approaches to build more holistic health…

Electronic Health Records (EHR) have been heavily used in modern healthcare systems for recording patients' admission information to hospitals. Many data-driven approaches employ temporal features in EHR for predicting specific diseases,…

Machine Learning · Computer Science 2021-12-07 Chang Lu , Chandan K. Reddy , Yue Ning

Understanding patterns of diagnoses, medications, procedures, and laboratory tests from electronic health records (EHRs) and health insurer claims is important for understanding disease risk and for efficient clinical development, which…

Machine Learning · Computer Science 2022-11-16 Ying Xu , Romane Gauriau , Anna Decker , Jacob Oppenheim

We develop a prediction-based prescriptive model for learning optimal personalized treatments for patients based on their Electronic Health Records (EHRs). Our approach consists of: (i) predicting future outcomes under each possible therapy…

Machine Learning · Statistics 2018-12-06 Ruidi Chen , Ioannis Paschalidis

Due to patient privacy protection concerns, machine learning research in healthcare has been undeniably slower and limited than in other application domains. High-quality, realistic, synthetic electronic health records (EHRs) can be…

Machine Learning · Computer Science 2023-02-10 Huan He , Shifan Zhao , Yuanzhe Xi , Joyce C Ho

This study proposes a Transformer-based longitudinal modeling method to address challenges in clinical risk classification with heterogeneous Electronic Health Record (EHR) data, including irregular temporal patterns, large modality…

Machine Learning · Computer Science 2025-11-07 Anzhuo Xie , Wei-Chen Chang

Measurement error arises commonly in clinical research settings that rely on data from electronic health records or large observational cohorts. In particular, self-reported outcomes are typical in cohort studies for chronic diseases such…

Methodology · Statistics 2021-02-08 Lillian A. Boe , Lesley F. Tinker , Pamela A. Shaw

With the recent availability of Electronic Health Records (EHR) and great opportunities they offer for advancing medical informatics, there has been growing interest in mining EHR for improving quality of care. Disease diagnosis due to its…

Artificial Intelligence · Computer Science 2018-04-24 Anahita Hosseini , Ting Chen , Wenjun Wu , Yizhou Sun , Majid Sarrafzadeh

Electronic Health Records (EHRs) contain extensive patient information that can inform downstream clinical decisions, such as mortality prediction, disease phenotyping, and disease onset prediction. A key challenge in EHR data analysis is…

Applications · Statistics 2026-01-01 Xin Gai , Shiyi Jiang , Anru R. Zhang

Electronic Health Records (EHR) offer rich real-world data for personalized medicine, providing insights into disease progression, treatment responses, and patient outcomes. However, their sparsity, heterogeneity, and high dimensionality…

Methodology · Statistics 2025-05-28 Linshanshan Wang , Mengyan Li , Zongqi Xia , Molei Liu , Tianxi Cai

Electronic Health Records (EHRs) provide crucial information for clinical decision-making. However, their high-dimensionality, heterogeneity, and sparsity make clinical prediction challenging. Large Language Models (LLMs) allowed progress…

Computation and Language · Computer Science 2026-01-28 Jesus Lovon-Melgarejo , Jose G. Moreno , Christine Damase-Michel , Lynda Tamine

Interval-censoring frequently occurs in studies of chronic diseases where disease status is inferred from intermittently collected biomarkers. Although many methods have been developed to analyze such data, they typically assume perfect…

Methodology · Statistics 2026-05-26 Yuhao Deng , Donglin Zeng , Yuanjia Wang

Although increasingly used as a data resource for assembling cohorts, electronic health records (EHRs) pose many analytic challenges. In particular, a patient's health status influences when and what data are recorded, generating sampling…

Methodology · Statistics 2020-04-28 Yifei Sun , Charles E. McCulloch , Kieren A. Marr , Chiung-Yu Huang

In the healthcare sector, the application of deep learning technologies has revolutionized data analysis and disease forecasting. This is particularly evident in the field of diabetes, where the deep analysis of Electronic Health Records…

Machine Learning · Computer Science 2024-12-06 Huadong Pang , Li Zhou , Yiping Dong , Peiyuan Chen , Dian Gu , Tianyi Lyu , Hansong Zhang

The increased availability of electronic health records (EHRs) have spearheaded the initiative for precision medicine using data driven approaches. Essential to this effort is the ability to identify patients with certain medical conditions…

In the dynamic hospital setting, decision support can be a valuable tool for improving patient outcomes. Data-driven inference of future outcomes is challenging in this dynamic setting, where long sequences such as laboratory tests and…

Quantitative Methods · Quantitative Biology 2024-04-25 Alan D. Kaplan , Priyadip Ray , John D. Greene , Vincent X. Liu

This research presents an examination of categorizing the severity states of patients based on their electronic health records during a certain time range using multiple machine learning and deep learning approaches. The suggested method…

Machine Learning · Computer Science 2022-09-30 A. N. M. Sajedul Alam , Rimi Reza , Asir Abrar , Tanvir Ahmed , Salsabil Ahmed , Shihab Sharar , Annajiat Alim Rasel

Joint modeling has become increasingly popular for characterizing the association between one or more longitudinal biomarkers and competing risks time-to-event outcomes. However, semiparametric multivariate joint modeling for large-scale…

Methodology · Statistics 2025-06-17 Shanpeng Li , Emily Ouyang , Jin Zhou , Xinping Cui , Gang Li

Despite the large progress in supervised learning with neural networks, there are significant challenges in obtaining high-quality, large-scale and accurately labelled datasets. In such a context, how to learn in the presence of noisy…

Computer Vision and Pattern Recognition · Computer Science 2024-09-09 Chen Feng , Georgios Tzimiropoulos , Ioannis Patras

Biobanks with genetics-linked electronic health records (EHR) have opened up opportunities to study associations between genetic, social, or environmental factors and longitudinal lab biomarkers. However, in EHRs, the timing of patient…

Methodology · Statistics 2025-05-23 Jiacong Du , Xu Shi , Bhramar Mukherjee