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The evaluation of the Human Epidermal growth factor Receptor-2 (HER2) expression is an important prognostic biomarker for breast cancer treatment selection. However, HER2 scoring has notoriously high interobserver variability due to stain…

Image and Video Processing · Electrical Eng. & Systems 2022-11-18 Manh Dan Pham , Cyprien Tilmant , Stéphanie Petit , Isabelle Salmon , Saima Ben Hadj , Rutger H. J. Fick

Accurate assessment of human epidermal growth factor receptor 2 (HER2) expression is critical for breast cancer diagnosis, prognosis, and therapy selection; yet, most existing digital HER2 scoring methods rely on bulky and expensive optical…

Medical Physics · Physics 2026-01-27 Che-Yung Shen , Xilin Yang , Yuzhu Li , Leon Lenk , Aydogan Ozcan

Breast cancer is the most common cancer among women worldwide. The human epidermal growth factor receptor 2 (HER2) with immunohistochemical (IHC) is widely used for pathological evaluation to provide the appropriate therapy for patients…

Quantitative Methods · Quantitative Biology 2022-03-08 Zichen Zhang , Lang Wang , Shuhao Wang

The overexpression of human epidermal growth factor receptor 2 (HER2) has been established as a therapeutic target in multiple types of cancers, such as breast and gastric cancers. Immunohistochemistry (IHC) is employed as a basic HER2 test…

Image and Video Processing · Electrical Eng. & Systems 2020-09-16 Jun Zhang , Kuan Tian , Pei Dong , Haocheng Shen , Kezhou Yan , Jianhua Yao , Junzhou Huang , Xiao Han

Evaluating expression of the Human epidermal growth factor receptor 2 (Her2) by visual examination of immunohistochemistry (IHC) on invasive breast cancer (BCa) is a key part of the diagnostic assessment of BCa due to its recognised…

Breast cancer, the most common malignancy among women, requires precise detection and classification for effective treatment. Immunohistochemistry (IHC) biomarkers like HER2, ER, and PR are critical for identifying breast cancer subtypes.…

Computer Vision and Pattern Recognition · Computer Science 2025-03-31 Ekansh Chauhan , Anila Sharma , Amit Sharma , Vikas Nishadham , Asha Ghughtyal , Ankur Kumar , Gurudutt Gupta , Anurag Mehta , C. V. Jawahar , P. K. Vinod

The current standard for detecting human epidermal growth factor receptor 2 (HER2) status in breast cancer patients relies on HER2 amplification, identified through fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC).…

Image and Video Processing · Electrical Eng. & Systems 2024-09-27 Ardhendu Sekhar , Vrinda Goel , Garima Jain , Abhijeet Patil , Ravi Kant Gupta , Tripti Bameta , Swapnil Rane , Amit Sethi

The overexpression of the human epidermal growth factor receptor 2 (HER2) in breast cells is a key driver of HER2-positive breast cancer, a highly aggressive subtype requiring precise diagnosis and targeted therapy. Immunohistochemistry…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Sara Rehmat , Hafeez Ur Rehman , Byeong-Gwon Kang , Sarra Ayouni , Yunyoung Nam

The immunohistochemical (IHC) staining of the human epidermal growth factor receptor 2 (HER2) biomarker is widely practiced in breast tissue analysis, preclinical studies and diagnostic decisions, guiding cancer treatment and investigation…

Breast cancer (BC) is the most common cancer among women world-wide, approximately 20-25% of BCs are HER-2 positive. Analysis of HER-2 is fundamental to defining the appropriate therapy for patients with breast cancer. Inter-pathologist…

Computer Vision and Pattern Recognition · Computer Science 2018-05-16 Caroline Q. Cordeiro , Sergio O. Ioshii , Jeovane H. Alves , Lucas F. Oliveira

Estimating over-amplification of human epidermal growth factor receptor 2 (HER2) on invasive breast cancer (BC) is regarded as a significant predictive and prognostic marker. We propose a novel deep reinforcement learning (DRL) based model…

Computer Vision and Pattern Recognition · Computer Science 2019-03-27 Talha Qaiser , Nasir M. Rajpoot

Generally, human epidermal growth factor 2 (HER2) breast cancer is more aggressive than other kinds of breast cancer. Currently, HER2 breast cancer is detected using expensive medical tests are most expensive. Therefore, the aim of this…

Image and Video Processing · Electrical Eng. & Systems 2022-11-22 M. F. Mridha , Md. Kishor Morol , Md. Asraf Ali , Md Sakib Hossain Shovon

The evaluation of human epidermal growth factor receptor 2 (HER2) expression is essential to formulate a precise treatment for breast cancer. The routine evaluation of HER2 is conducted with immunohistochemical techniques (IHC), which is…

Image and Video Processing · Electrical Eng. & Systems 2022-05-11 Shengjie Liu , Chuang Zhu , Feng Xu , Xinyu Jia , Zhongyue Shi , Mulan Jin

Human epidermal growth factor receptor 2 (HER2) is an important prognostic and predictive factor which is overexpressed in 15-20% of breast cancer (BCa). The determination of its status is a key clinical decision making step for selection…

Computer Vision and Pattern Recognition · Computer Science 2021-10-13 Wenqi Lu , Michael Toss , Emad Rakha , Nasir Rajpoot , Fayyaz Minhas

Immunohistochemistry (IHC) analysis is a well-accepted and widely used method for molecular subtyping, a procedure for prognosis and targeted therapy of breast carcinoma, the most common type of tumor affecting women. There are four…

Image and Video Processing · Electrical Eng. & Systems 2024-06-18 Sumit Kumar Jha , Purnendu Mishra , Shubham Mathur , Gursewak Singh , Rajiv Kumar , Kiran Aatre , Suraj Rengarajan

Expression of human epidermal growth factor receptor 2 (HER2) is an important biomarker in breast cancer patients who can benefit from cost-effective automatic Hematoxylin and Eosin (H\&E) HER2 scoring. However, developing such scoring…

Computer Vision and Pattern Recognition · Computer Science 2024-11-11 Rawan S. Abdulsadig , Bryan M. Williams , Nikolay Burlutskiy

Histo-pathological diagnostics are an inherent part of the everyday work but are particularly laborious and associated with time-consuming manual analysis of image data. In order to cope with the increasing diagnostic case numbers due to…

Gene expression can be used to subtype breast cancer with improved prediction of risk of recurrence and treatment responsiveness over that obtained using routine immunohistochemistry (IHC). However, in the clinic, molecular profiling is…

Computer Vision and Pattern Recognition · Computer Science 2023-05-09 Raktim Kumar Mondol , Ewan K. A. Millar , Peter H Graham , Lois Browne , Arcot Sowmya , Erik Meijering

For invasive breast cancer, immunohistochemical (IHC) techniques are often used to detect the expression level of human epidermal growth factor receptor-2 (HER2) in breast tissue to formulate a precise treatment plan. From the perspective…

The popular use of histopathology images, such as hematoxylin and eosin (H&E), has proven to be useful in detecting tumors. However, moving such cancer cases forward for treatment requires accurate on the amount of the human epidermal…

Computer Vision and Pattern Recognition · Computer Science 2025-12-30 Olaide N. Oyelade , Oliver Hoxey , Yulia Humrye
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