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Ill-posed inverse problems are fundamental in many domains, ranging from astrophysics to medical imaging. Emerging diffusion models provide a powerful prior for solving these problems. Existing maximum-a-posteriori (MAP) or posterior…

Computer Vision and Pattern Recognition · Computer Science 2026-05-15 Minseo Kim , Axel Levy , Gordon Wetzstein

Diffusion models have indeed shown great promise in solving inverse problems in image processing. In this paper, we propose a novel, problem-agnostic diffusion model called the maximum a posteriori (MAP)-based guided term estimation method…

Image and Video Processing · Electrical Eng. & Systems 2026-03-10 Pingping Tao , Haixia Liu , Jing Su

In this paper we consider a mathematical model for photoacoustic imaging which takes into account attenuation due to thermodynamic dissipation. The propagation of acoustic (compressional) waves is governed by a scalar wave equation coupled…

Analysis of PDEs · Mathematics 2016-10-12 Sebastian Acosta , Carlos Montalto

Reconstructing medical images from partial measurements is an important inverse problem in Computed Tomography (CT) and Magnetic Resonance Imaging (MRI). Existing solutions based on machine learning typically train a model to directly map…

Image and Video Processing · Electrical Eng. & Systems 2022-06-17 Yang Song , Liyue Shen , Lei Xing , Stefano Ermon

In photoacoustic tomography (PAT), the computation of the initial pressure distribution within an object from its time-dependent boundary measurements over time is considered. This problem can be approached from two well-established points…

Numerical Analysis · Mathematics 2025-07-04 Jaakko Kultima , Ronny Ramlau , Teemu Sahlström , Tanja Tarvainen

In this paper, we describe the numerical reconstruction method for quantitative photoacoustic tomography (QPAT) based on the radiative transfer equation (RTE), which models light propagation more accurately than diffusion approximation…

Quantitative Methods · Quantitative Biology 2017-10-25 Chao Wang , Tie Zhou

Photoacoustic imaging is an emerging imaging modality that is based upon the photoacoustic effect. In photoacoustic tomography (PAT), the induced acoustic pressure waves are measured by an array of detectors and used to reconstruct an image…

Computer Vision and Pattern Recognition · Computer Science 2019-04-26 Steven Guan , Amir Khan , Siddhartha Sikdar , Parag V. Chitnis

Diffusion models have emerged as the new state-of-the-art generative model with high quality samples, with intriguing properties such as mode coverage and high flexibility. They have also been shown to be effective inverse problem solvers,…

Computer Vision and Pattern Recognition · Computer Science 2025-10-06 Hyungjin Chung , Dohoon Ryu , Michael T. McCann , Marc L. Klasky , Jong Chul Ye

Diffusion models are widely used in applications ranging from image generation to inverse problems. However, training diffusion models typically requires clean ground-truth images, which are unavailable in many applications. We introduce…

Image and Video Processing · Electrical Eng. & Systems 2025-05-20 Chicago Y. Park , Shirin Shoushtari , Hongyu An , Ulugbek S. Kamilov

We introduce Diffusion Active Learning, a novel approach that combines generative diffusion modeling with data-driven sequential experimental design to adaptively acquire data for inverse problems. Although broadly applicable, we focus on…

Machine Learning · Computer Science 2025-04-07 Luis Barba , Johannes Kirschner , Tomas Aidukas , Manuel Guizar-Sicairos , Benjamín Béjar

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is a rapidly emerging hybrid imaging technique that possesses great potential for a wide range of biomedical imaging applications. In OAT, a laser is employed to…

Medical Physics · Physics 2016-12-21 Yang Lou , Kun Wang , Alexander. A. Oraevsky , Mark. A. Anastasio

We investigate the inverse source problem for the wave equation, arising in photo- and thermoacoustic tomography. There exist quite a few theoretically exact inversion formulas explicitly expressing solution of this problem in terms of the…

Analysis of PDEs · Mathematics 2018-08-01 Ngoc Do , Leonid Kunyansky

Recent advances in diffusion models have demonstrated exceptional performance in generative tasks across vari-ous fields. In positron emission tomography (PET), the reduction in tracer dose leads to information loss in sino-grams. Using…

Machine Learning · Computer Science 2024-11-11 Xingyu Ai , Bin Huang , Fang Chen , Liu Shi , Binxuan Li , Shaoyu Wang , Qiegen Liu

Inverse problems arise in a multitude of applications, where the goal is to recover a clean signal from noisy and possibly (non)linear observations. The difficulty of a reconstruction problem depends on multiple factors, such as the ground…

Image and Video Processing · Electrical Eng. & Systems 2024-08-21 Zalan Fabian , Berk Tinaz , Mahdi Soltanolkotabi

Diffusion models have recently achieved success in solving Bayesian inverse problems with learned data priors. Current methods build on top of the diffusion sampling process, where each denoising step makes small modifications to samples…

Machine Learning · Computer Science 2025-08-19 Bingliang Zhang , Wenda Chu , Julius Berner , Chenlin Meng , Anima Anandkumar , Yang Song

Diffusion models have achieved excellent success in solving inverse problems due to their ability to learn strong image priors, but existing approaches require a large training dataset of images that should come from the same distribution…

Computer Vision and Pattern Recognition · Computer Science 2024-10-16 Jason Hu , Bowen Song , Jeffrey A. Fessler , Liyue Shen

Optoacoustic tomography (OAT), also known as photoacoustic tomography, is an emerging computed biomedical imaging modality that exploits optical contrast and ultrasonic detection principles. Iterative image reconstruction algorithms that…

Medical Physics · Physics 2016-11-17 Kun Wang , Robert W Schoonover , Richard Su , Alexander Oraevsky , Mark A Anastasio

Score-based diffusion modeling is a generative machine learning algorithm that can be used to sample from complex distributions. They achieve this by learning a score function, i.e., the gradient of the log-probability density of the data,…

Machine Learning · Computer Science 2025-12-17 Dibyajyoti Chakraborty , Haiwen Guan , Jason Stock , Troy Arcomano , Guido Cervone , Romit Maulik

In this paper, we propose an approach combining diffusion models and inverse problems for the reconstruction of circumstellar disk images. Our method builds upon the Rhapsodie framework for polarimetric imaging, substituting its classical…

Instrumentation and Methods for Astrophysics · Physics 2025-10-17 Quentin Villegas , Laurence Denneulin , Simon Prunet , André Ferrari , Nelly Pustelnik , Éric Thiébaut , Julian Tachella , Maud Langlois

PET suffers from a low signal-to-noise ratio. Meanwhile, the k-space data acquisition process in MRI is time-consuming by PET-MRI systems. We aim to accelerate MRI and improve PET image quality. This paper proposed a novel joint…

Computer Vision and Pattern Recognition · Computer Science 2024-08-23 Taofeng Xie , Zhuoxu Cui , Congcong Liu , Chen Luo , Huayu Wang , Yuanzhi Zhang , Xuemei Wang , Yihang Zhou , Qiyu Jin , Guoqing Chen , Dong Liang , Haifeng Wang