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The size and quality of chemical libraries to the drug discovery pipeline are crucial for developing new drugs or repurposing existing drugs. Existing techniques such as combinatorial organic synthesis and High-Throughput Screening usually…

Biomolecules · Quantitative Biology 2020-10-02 Brighter Agyemang , Wei-Ping Wu , Daniel Addo , Michael Y. Kpiebaareh , Ebenezer Nanor , Charles Roland Haruna

We consider the problem of learning deep generative models from data. We formulate a method that generates an independent sample via a single feedforward pass through a multilayer perceptron, as in the recently proposed generative…

Machine Learning · Computer Science 2015-02-11 Yujia Li , Kevin Swersky , Richard Zemel

This work introduces a novel system for the generation of images that contain multiple classes of objects. Recent work in Generative Adversarial Networks have produced high quality images, but many focus on generating images of a single…

Machine Learning · Computer Science 2019-11-11 Elijah D. Bolluyt , Cristina Comaniciu

In recent years, reinforcement learning (RL) has emerged as a valuable tool in drug design, offering the potential to propose and optimize molecules with desired properties. However, striking a balance between capabilities, flexibility,…

Generative adversarial networks (GANs) can implicitly learn rich distributions over images, audio, and data which are hard to model with an explicit likelihood. We present a practical Bayesian formulation for unsupervised and…

Machine Learning · Statistics 2017-11-09 Yunus Saatchi , Andrew Gordon Wilson

This paper introduces MarketGAN, a factor-based generative framework for high-dimensional asset return generation under severe data scarcity. We embed an explicit asset-pricing factor structure as an economic inductive bias and generate…

Statistical Finance · Quantitative Finance 2026-01-27 Jeonggyu Huh , Seungwon Jeong , Hyun-Gyoon Kim , Hyeng Keun Koo , Byung Hwa Lim

Magnetic Resonance Angiography (MRA) has become an essential MR contrast for imaging and evaluation of vascular anatomy and related diseases. MRA acquisitions are typically ordered for vascular interventions, whereas in typical scenarios,…

Computer Vision and Pattern Recognition · Computer Science 2018-04-13 Sahin Olut , Yusuf Huseyin Sahin , Ugur Demir , Gozde Unal

Automatic modulation classification (AMC) using the Deep Neural Network (DNN) approach outperforms the traditional classification techniques, even in the presence of challenging wireless channel environments. However, the adversarial…

Machine Learning · Computer Science 2022-06-01 Eyad Shtaiwi , Ahmed El Ouadrhiri , Majid Moradikia , Salma Sultana , Ahmed Abdelhadi , Zhu Han

Compressed sensing (CS) leverages the sparsity prior to provide the foundation for fast magnetic resonance imaging (fastMRI). However, iterative solvers for ill-posed problems hinder their adaption to time-critical applications. Moreover,…

Image and Video Processing · Electrical Eng. & Systems 2021-03-16 Jingshuai Liu , Mehrdad Yaghoobi

Generative Adversarial Networks (GANs) have shown great promise recently in image generation. Training GANs for language generation has proven to be more difficult, because of the non-differentiable nature of generating text with recurrent…

Computation and Language · Computer Science 2017-12-22 Ofir Press , Amir Bar , Ben Bogin , Jonathan Berant , Lior Wolf

We study the problem of multimodal generative modelling of images based on generative adversarial networks (GANs). Despite the success of existing methods, they often ignore the underlying structure of vision data or its multimodal…

Machine Learning · Computer Science 2019-11-07 Lili Pan , Shen Cheng , Jian Liu , Yazhou Ren , Zenglin Xu

Geostatistical modeling of petrophysical properties is a key step in modern integrated oil and gas reservoir studies. Recently, generative adversarial networks (GAN) have been shown to be a successful method for generating unconditional…

Machine Learning · Statistics 2018-02-16 Lukas Mosser , Olivier Dubrule , Martin J. Blunt

A myriad of recent literary works has leveraged generative adversarial networks (GANs) to generate unseen evasion samples. The purpose is to annex the generated data with the original train set for adversarial training to improve the…

Cryptography and Security · Computer Science 2022-08-09 Rizwan Hamid Randhawa , Nauman Aslam , Mohammad Alauthman , Husnain Rafiq

The de novo design of molecular structures using deep learning generative models introduces an encouraging solution to drug discovery in the face of the continuously increased cost of new drug development. From the generation of original…

Biomolecules · Quantitative Biology 2021-02-08 Yuemin Bian , Xiang-Qun Xie

The inverse mapping of GANs'(Generative Adversarial Nets) generator has a great potential value.Hence, some works have been developed to construct the inverse function of generator by directly learning or adversarial learning.While the…

Machine Learning · Computer Science 2017-09-13 Junyu Luo , Yong Xu , Chenwei Tang , Jiancheng Lv

We propose a novel technique to make neural network robust to adversarial examples using a generative adversarial network. We alternately train both classifier and generator networks. The generator network generates an adversarial…

Machine Learning · Computer Science 2023-07-06 Hyeungill Lee , Sungyeob Han , Jungwoo Lee

Despite the successes in capturing continuous distributions, the application of generative adversarial networks (GANs) to discrete settings, like natural language tasks, is rather restricted. The fundamental reason is the difficulty of…

Artificial Intelligence · Computer Science 2017-02-28 Tong Che , Yanran Li , Ruixiang Zhang , R Devon Hjelm , Wenjie Li , Yangqiu Song , Yoshua Bengio

Malware detectors based on machine learning (ML) have been shown to be susceptible to adversarial malware examples. However, current methods to generate adversarial malware examples still have their limits. They either rely on detailed…

Cryptography and Security · Computer Science 2023-08-22 Daniel Gibert , Jordi Planes , Quan Le , Giulio Zizzo

Generative Adversarial Networks (GANs) can successfully approximate a probability distribution and produce realistic samples. However, open questions such as sufficient convergence conditions and mode collapse still persist. In this paper,…

Machine Learning · Computer Science 2019-03-13 Thang Doan , Joao Monteiro , Isabela Albuquerque , Bogdan Mazoure , Audrey Durand , Joelle Pineau , R Devon Hjelm

Existing drug discovery pipelines take 5-10 years and cost billions of dollars. Computational approaches aim to sample from regions of the whole molecular and solid-state compounds called chemical space which could be on the order of 1060 .…

Emerging Technologies · Computer Science 2021-01-12 Junde Li , Rasit Topaloglu , Swaroop Ghosh