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Molecular fingerprints are significant cheminformatics tools to map molecules into vectorial space according to their characteristics in diverse functional groups, atom sequences, and other topological structures. In this paper, we set out…

Applications · Statistics 2023-01-05 Xue Liu , Qian Cheng , Dan Sun , Xing Li , Wei Wei , Zhiming Zheng

HYPERTILING is a high-performance Python library for the generation and visualization of regular hyperbolic lattices embedded in the Poincar\'e disk model. Using highly optimized, efficient algorithms, hyperbolic tilings with millions of…

Computational Physics · Physics 2024-06-27 Manuel Schrauth , Yanick Thurn , Florian Goth , Jefferson S. E. Portela , Dietmar Herdt , Felix Dusel

Discovering materials with desirable properties in an efficient way remains a significant problem in materials science. Many studies have tackled this problem by using different sets of information available about the materials. Among them,…

Materials Science · Physics 2025-03-04 Onur Boyar , Indra Priyadarsini , Seiji Takeda , Lisa Hamada

In this paper, we present resolvent4py, a parallel Python package for the analysis, model reduction and control of large-scale linear systems with millions or billions of degrees of freedom. This package provides the user with a friendly…

The growing demand for machine learning in healthcare requires processing increasingly large electronic health record (EHR) datasets, but existing pipelines are not computationally efficient or scalable. In this paper, we introduce…

Machine Learning · Computer Science 2024-11-18 Ethan Steinberg , Michael Wornow , Suhana Bedi , Jason Alan Fries , Matthew B. A. McDermott , Nigam H. Shah

The rapidly evolving landscape of AI and machine learning workloads has widened the gap between high-level domain operations and efficient hardware utilization. Achieving near-peak performance still demands deep hardware expertise-experts…

Machine Learning · Computer Science 2025-11-19 Arun Thangamani , Md Asghar Ahmad Shahid , Adam Siemieniuk , Rolf Morel , Renato Golin , Alexander Heinecke

To execute scientific computing programs such as deep learning at high speed, GPU acceleration is a powerful option. With the recent advancements in web technologies, interfaces like WebGL and WebGPU, which utilize GPUs on the client side…

Distributed, Parallel, and Cluster Computing · Computer Science 2025-03-04 Masatoshi Hidaka , Tatsuya Harada

Correct performance assessment is crucial for evaluating modern artificial intelligence algorithms in medicine like deep-learning based medical image segmentation models. However, there is no universal metric library in Python for…

Computer Vision and Pattern Recognition · Computer Science 2022-01-25 Dominik Müller , Dennis Hartmann , Philip Meyer , Florian Auer , Iñaki Soto-Rey , Frank Kramer

As data are generated more and more from multiple disparate sources, multiview data sets, where each sample has features in distinct views, have ballooned in recent years. However, no comprehensive package exists that enables…

Protein language models (PLMs) have shown promise in improving the understanding of protein sequences, contributing to advances in areas such as function prediction and protein engineering. However, training these models from scratch…

Machine Learning · Computer Science 2024-12-19 Shivasankaran Vanaja Pandi , Bharath Ramsundar

Computing has revolutionized the biological sciences over the past several decades, such that virtually all contemporary research in the biosciences utilizes computer programs. The computational advances have come on many fronts, spurred by…

Other Quantitative Biology · Quantitative Biology 2021-08-23 Berk Ekmekci , Charles E. McAnany , Cameron Mura

We introduce the first formal large-scale assessment of the utility of traditional chemical functional groups as used in chemical explanations. Our assessment employs a fundamental principle from computational learning theory: a good…

Machine Learning · Computer Science 2025-11-11 Ruben Sharma , Ross D. King

With recent advancements in machine learning for interatomic potentials, Python has become the go-to programming language for exploring new ideas. While machine-learning potentials are often developed in Python-based frameworks, existing…

The theory of divide-and-conquer parallelization has been well-studied in the past, providing a solid basis upon which to explore different approaches to the parallelization of merge sort in Python. Python's simplicity and extensive…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-11-30 Alexandra Yang

ParaMonte::Python (standing for Parallel Monte Carlo in Python) is a serial and MPI-parallelized library of (Markov Chain) Monte Carlo (MCMC) routines for sampling mathematical objective functions, in particular, the posterior distributions…

Mathematical Software · Computer Science 2020-10-05 Amir Shahmoradi , Fatemeh Bagheri , Joshua Alexander Osborne

This research explores the application of quadratic polynomials in Python for advanced data analysis. The study demonstrates how quadratic models can effectively capture nonlinear relationships in complex datasets by leveraging Python…

Methodology · Statistics 2025-09-16 Rostyslav Sipakov , Olena Voloshkina , Anastasiia Kovalova

Molecular fingerprints are the workhorse in ligand-based drug discovery. In recent years, an increasing number of research papers reported fascinating results on using deep neural networks to learn 2D molecular representations as…

Quantitative Methods · Quantitative Biology 2020-06-25 Yanxing Wang , Jianxing Hu , Junyong Lai , Yibo Li , Hongwei Jin , Lihe Zhang , Liangren Zhang , Zhenming Liu

The amazing advances being made in the fields of machine and deep learning are a highlight of the Big Data era for both enterprise and research communities. Modern applications require resources beyond a single node's ability to provide.…

High-throughput approximations of quantum mechanics calculations and combinatorial experiments have been traditionally used to reduce the search space of possible molecules, drugs and materials. However, the interplay of structural and…

Quantum Physics · Physics 2019-10-29 Alain Tchagang , Julio Valdés

Herein we review aspects of leading-edge research and innovation in chemistry which exploits big data and machine learning (ML), two computer science fields that combine to yield machine intelligence. ML can accelerate the solution of…