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We propose a novel molecular fingerprint-based variational autoencoder applied for molecular generation on real-world drug molecules. We define more suitable and pharma-relevant baseline metrics and tests, focusing on the generation of…

Machine Learning · Computer Science 2022-11-17 Ruslan N. Tazhigulov , Joshua Schiller , Jacob Oppenheim , Max Winston

The fast-paced development of machine learning (ML) methods coupled with its increasing adoption in research poses challenges for researchers without extensive training in ML. In neuroscience, for example, ML can help understand…

Machine Learning · Computer Science 2023-10-20 Sami Hamdan , Shammi More , Leonard Sasse , Vera Komeyer , Kaustubh R. Patil , Federico Raimondo

mlpy is a Python Open Source Machine Learning library built on top of NumPy/SciPy and the GNU Scientific Libraries. mlpy provides a wide range of state-of-the-art machine learning methods for supervised and unsupervised problems and it is…

Mathematical Software · Computer Science 2012-03-02 Davide Albanese , Roberto Visintainer , Stefano Merler , Samantha Riccadonna , Giuseppe Jurman , Cesare Furlanello

sQUlearn introduces a user-friendly, NISQ-ready Python library for quantum machine learning (QML), designed for seamless integration with classical machine learning tools like scikit-learn. The library's dual-layer architecture serves both…

There are many ways to represent a molecule as input to a machine learning model and each is associated with loss and retention of certain kinds of information. In the interest of preserving three-dimensional spatial information, including…

Machine Learning · Computer Science 2019-12-11 Jocelyn Sunseri , David Ryan Koes

We describe how Python can be leveraged to streamline the curation, modelling and dissemination of drug discovery data as well as the development of innovative, freely available tools for the related scientific community. We look at various…

Other Computer Science · Computer Science 2016-07-05 Michał Nowotka , George Papadatos , Mark Davies , Nathan Dedman , Anne Hersey

Deep metric learning algorithms have a wide variety of applications, but implementing these algorithms can be tedious and time consuming. PyTorch Metric Learning is an open source library that aims to remove this barrier for both…

Computer Vision and Pattern Recognition · Computer Science 2020-08-24 Kevin Musgrave , Serge Belongie , Ser-Nam Lim

Wavelets and Multiwavelets have lately been adopted in Quantum Chemistry to overcome challenges presented by the two main families of basis sets: Gaussian atomic orbitals and plane waves. In addition to their numerical advantages (high…

Polymer informatics tools have been recently gaining ground to efficiently and effectively develop, design, and discover new polymers that meet specific application needs. So far, however, these data-driven efforts have largely focused on…

Materials Science · Physics 2021-07-05 Christopher Künneth , William Schertzer , Rampi Ramprasad

A large amount of data is produced every second from modern information systems such as mobile devices, the world wide web, Internet of Things, social media, etc. Analysis and mining of this massive data requires a lot of advanced tools and…

Machine Learning · Computer Science 2020-01-13 Rising Odegua , Festus Ikpotokin

With the increased availability of rich tactile sensors, there is an equally proportional need for open-source and integrated software capable of efficiently and effectively processing raw touch measurements into high-level signals that can…

Robotics · Computer Science 2021-05-28 Mike Lambeta , Huazhe Xu , Jingwei Xu , Po-Wei Chou , Shaoxiong Wang , Trevor Darrell , Roberto Calandra

Python has become the prime language for application development in the Data Science and Machine Learning domains. However, data scientists are not necessarily experienced programmers. While Python lets them quickly implement their…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-08-24 Oscar Castro , Pierrick Bruneau , Jean-Sébastien Sottet , Dario Torregrossa

In recent years, deep learning revolutionized machine learning and its applications, producing results comparable to human experts in several domains, including neuroscience. Each year, hundreds of scientific publications present…

Quantitative Methods · Quantitative Biology 2023-01-13 Louis Fabrice Tshimanga , Manfredo Atzori , Federico Del Pup , Maurizio Corbetta

Polymers are a vital part of everyday life. Their chemical universe is so large that it presents unprecedented opportunities as well as significant challenges to identify suitable application-specific candidates. We present a complete…

Materials Science · Physics 2023-07-20 Christopher Kuenneth , Rampi Ramprasad

Molecular dynamics simulations play an increasingly important role in the rational design of (nano)-materials and in the study of biomacromolecules. However, generating input files and realistic starting coordinates for these simulations is…

Recent advances in computational methods for designing biological sequences have sparked the development of metrics to evaluate these methods performance in terms of the fidelity of the designed sequences to a target distribution and their…

In this work, we present the ChemNLP library that can be used for 1) curating open access datasets for materials and chemistry literature, developing and comparing traditional machine learning, transformers and graph neural network models…

Materials Science · Physics 2024-02-19 Kamal Choudhary , Mathew L. Kelley

The democratization of Data Mining has been widely successful thanks in part to powerful and easy-to-use Machine Learning libraries. These libraries have been particularly tailored to tackle Supervised Learning. However, strong supervision…

Machine Learning · Computer Science 2023-08-21 Pierre Nodet , Vincent Lemaire , Alexis Bondu , Antoine Cornuéjols

DeeProb-kit is a unified library written in Python consisting of a collection of deep probabilistic models (DPMs) that are tractable and exact representations for the modelled probability distributions. The availability of a representative…

Machine Learning · Computer Science 2022-12-09 Lorenzo Loconte , Gennaro Gala

Deep learning has enabled major advances in the fields of computer vision, natural language processing, and multimedia among many others. Developing a deep learning system is arduous and complex, as it involves constructing neural network…

Machine Learning · Computer Science 2017-08-04 Hao Dong , Akara Supratak , Luo Mai , Fangde Liu , Axel Oehmichen , Simiao Yu , Yike Guo