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To discover new drugs is to seek and to prove causality. As an emerging approach leveraging human knowledge and creativity, data, and machine intelligence, causal inference holds the promise of reducing cognitive bias and improving decision…

Quantitative Methods · Quantitative Biology 2025-04-09 Tom Michoel , Jitao David Zhang

We derive a set of causal deep neural networks whose architectures are a consequence of tensor (multilinear) factor analysis, a framework that facilitates causal inference. Forward causal questions are addressed with a neural network…

Machine Learning · Computer Science 2025-06-17 M. Alex O. Vasilescu

Deep learning implemented via neural networks, has revolutionized machine learning by providing methods for complex tasks such as object detection/classification and prediction. However, architectures based on deep neural networks have…

Machine Learning · Computer Science 2025-02-11 Nanjangud C. Narendra , Nithin Nagaraj

We consider learning ancestral causal relationships in high dimensions. Our approach is driven by a supervised learning perspective, with discrete indicators of causal relationships treated as labels to be learned from available data. We…

Machine Learning · Statistics 2019-05-29 Umberto Noè , Bernd Taschler , Joachim Täger , Peter Heutink , Sach Mukherjee

Causal inference is a fundamental research topic for discovering the cause-effect relationships in many disciplines. However, not all algorithms are equally well-suited for a given dataset. For instance, some approaches may only be able to…

Machine Learning · Computer Science 2024-03-11 Zhipeng Ma , Marco Kemmerling , Daniel Buschmann , Chrismarie Enslin , Daniel Lütticke , Robert H. Schmitt

Going beyond correlations, the understanding and identification of causal relationships in observational time series, an important subfield of Causal Discovery, poses a major challenge. The lack of access to a well-defined ground truth for…

Machine Learning · Statistics 2021-04-19 Andrew R. Lawrence , Marcus Kaiser , Rui Sampaio , Maksim Sipos

Causal structure learning refers to a process of identifying causal structures from observational data, and it can have multiple applications in biomedicine and health care. This paper provides a practical review and tutorial on scalable…

Machine Learning · Computer Science 2023-01-20 Pulakesh Upadhyaya , Kai Zhang , Can Li , Xiaoqian Jiang , Yejin Kim

We address the problem of counterfactual regression using causal inference (CI) in observational studies consisting of high dimensional covariates and high cardinality treatments. Confounding bias, which leads to inaccurate treatment effect…

Methodology · Statistics 2021-04-12 Ankit Sharma , Garima Gupta , Ranjitha Prasad , Arnab Chatterjee , Lovekesh Vig , Gautam Shroff

It has long been noticed that high dimension data exhibits strange patterns. This has been variously interpreted as either a "blessing" or a "curse", causing uncomfortable inconsistencies in the literature. We propose that these patterns…

Computer Vision and Pattern Recognition · Computer Science 2020-03-18 Wen-Yan Lin

The fundamental challenge of drawing causal inference is that counterfactual outcomes are not fully observed for any unit. Furthermore, in observational studies, treatment assignment is likely to be confounded. Many statistical methods have…

Methodology · Statistics 2022-08-01 Harsh Parikh , Carlos Varjao , Louise Xu , Eric Tchetgen Tchetgen

Causal discovery in time-series is a fundamental problem in the machine learning community, enabling causal reasoning and decision-making in complex scenarios. Recently, researchers successfully discover causality by combining neural…

Machine Learning · Computer Science 2023-08-17 Yuxiao Cheng , Lianglong Li , Tingxiong Xiao , Zongren Li , Qin Zhong , Jinli Suo , Kunlun He

Massive data collection holds the promise of a better understanding of complex phenomena and, ultimately, better decisions. Representation learning has become a key driver of deep learning applications, as it allows learning latent spaces…

Machine Learning · Computer Science 2025-11-10 Caroline Uhler , Jiaqi Zhang

Causal inference from observation data is a core problem in many scientific fields. Here we present a general supervised deep learning framework that infers causal interactions by transforming the input vectors to an image-like…

Machine Learning · Computer Science 2020-11-26 Ye Yuan , Xueying Ding , Ziv Bar-Joseph

Causal inference has been a pivotal challenge across diverse domains such as medicine and economics, demanding a complicated integration of human knowledge, mathematical reasoning, and data mining capabilities. Recent advancements in…

Computation and Language · Computer Science 2025-02-11 Jing Ma

Causal inference is capable of estimating the treatment effect (i.e., the causal effect of treatment on the outcome) to benefit the decision making in various domains. One fundamental challenge in this research is that the treatment…

Machine Learning · Computer Science 2021-12-28 Qian Li , Zhichao Wang , Shaowu Liu , Gang Li , Guandong Xu

Accurate estimation of counterfactual outcomes in high-dimensional data is crucial for decision-making and understanding causal relationships and intervention outcomes in various domains, including healthcare, economics, and social…

Machine Learning · Computer Science 2024-07-31 Jiageng Zhu , Hanchen Xie , Jiazhi Li , Wael Abd-Almageed

Discovering the underlying dynamics of complex systems from data is an important practical topic. Constrained optimization algorithms are widely utilized and lead to many successes. Yet, such purely data-driven methods may bring about…

Dynamical Systems · Mathematics 2023-05-17 Nan Chen , Yinling Zhang

The paper reviews methods that seek to draw causal inference from observational data and demonstrates how they can be applied to empirical problems in engineering research. It presents a framework for causal identification based on the…

Applications · Statistics 2022-11-28 Daniel J Graham

Survey scientists increasingly face the problem of high-dimensionality in their research as digitization makes it much easier to construct high-dimensional (or "big") data sets through tools such as online surveys and mobile applications.…

Methodology · Statistics 2021-02-19 Barbara Felderer , Jannis Kueck , Martin Spindler

Understanding causality helps to structure interventions to achieve specific goals and enables predictions under interventions. With the growing importance of learning causal relationships, causal discovery tasks have transitioned from…

Machine Learning · Computer Science 2022-09-15 Hang Chen , Keqing Du , Xinyu Yang , Chenguang Li