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Inferring causal effects from an observational study is challenging because participants are not randomized to treatment. Observational studies in infectious disease research present the additional challenge that one participant's treatment…

Methodology · Statistics 2020-12-25 Brian G. Barkley , Michael G. Hudgens , John D. Clemens , Mohammad Ali , Michael E. Emch

Coronary Heart Disease affects millions of people worldwide and is a well-studied area of healthcare. There are many viable and accurate methods for the diagnosis and prediction of heart disease, but they have limiting points such as…

Artificial Intelligence · Computer Science 2024-09-24 Jamal Al-Karaki , Philip Ilono , Sanchit Baweja , Jalal Naghiyev , Raja Singh Yadav , Muhammad Al-Zafar Khan

In this expository paper, we consider the problem of causal inference and efficient estimation for the counterfactual survivor function. This problem has previously been considered in the literature in several papers, each relying on the…

Methodology · Statistics 2025-10-02 Benjamin R. Baer , Ashkan Ertefaie , Robert L. Strawderman

We propose a new model for comprehensively monitoring the health status of individuals by calculating a personal health index. The central framework of the model is the International Classification of Functioning, Disability and Health…

Computers and Society · Computer Science 2023-04-14 Ilkka Rautiainen , Lauri Parviainen , Veera Jakoaho , Sami Äyrämö , Jukka-Pekka Kauppi

Estimating causal effects in a target population with unmeasured confounders is challenging, especially when instrumental variables (IVs) are unavailable. However, IVs from auxiliary populations with similar problems can help infer causal…

Methodology · Statistics 2025-08-06 Wei Li , Jiapeng Liu , Peng Ding , Zhi Geng

Consider informative selection of a sample from a finite population. Responses are realized as independent and identically distributed (i.i.d.) random variables with a probability density function (p.d.f.) f, referred to as the…

Statistics Theory · Mathematics 2012-11-26 Daniel Bonnéry , F. Jay Breidt , François Coquet

Data analysis based on information from several sources is common in economic and biomedical studies. This setting is often referred to as the data fusion problem, which differs from traditional missing data problems since no complete data…

Methodology · Statistics 2022-04-07 Wei Li , Shanshan Luo , Wangli Xu

Human face aging is irreversible process causing changes in human face characteristics such us hair whitening, muscles drop and wrinkles. Due to the importance of human face aging in biometrics systems, age estimation became an attractive…

Computer Vision and Pattern Recognition · Computer Science 2016-01-11 Salah Eddine Bekhouche , Abdelkrim Ouafi , Abdelmalik Taleb-Ahmed , Abdenour Hadid , Azeddine Benlamoudi

This paper introduces aggregate Bayesian Causal Forests (aBCF), a new Bayesian model for causal inference using aggregated data. Aggregated data are common in policy evaluations where we observe individuals such as students, but…

Federated or multi-site studies have distinct advantages over single-site studies, including increased generalizability, the ability to study underrepresented populations, and the opportunity to study rare exposures and outcomes. However,…

Machine Learning · Statistics 2023-09-25 Larry Han , Zhu Shen , Jose Zubizarreta

The population-attributable fraction (PAF) is a popular epidemiological measure for the burden of a harmful exposure within a population. It is often interpreted causally as proportion of preventable cases after an elimination of exposure.…

Methodology · Statistics 2019-08-22 Maja von Cube , Martin Schumacher , Martin Wolkewitz

We propose and study a fully efficient method to estimate associations of an exposure with disease incidence when both, incident cases and prevalent cases, i.e. individuals who were diagnosed with the disease at some prior time point and…

Methodology · Statistics 2018-03-20 Marlena Maziarz , Yukun Liu , Jing Qin , Ruth Pfeiffer

We consider time to treatment initiation. This can commonly occur in preventive medicine, such as disease screening and vaccination; it can also occur with non-fatal health conditions such as HIV infection without the onset of AIDS. While…

Methodology · Statistics 2026-05-29 Zhichen Zhao , Andrew Ying , Ronghui Xu

Causal inference methods are widely applied in various decision-making domains such as precision medicine, optimal policy and economics. Central to causal inference is the treatment effect estimation of intervention strategies, such as…

Artificial Intelligence · Computer Science 2021-05-31 Tri Dung Duong , Qian Li , Guandong Xu

Clinical predictive algorithms are increasingly being used to form the basis for optimal treatment policies--that is, to enable interventions to be targeted to the patients who will presumably benefit most. Despite taking advantage of…

Applications · Statistics 2020-07-21 Ben J. Marafino , Alejandro Schuler , Vincent X. Liu , Gabriel J. Escobar , Mike Baiocchi

Coronary microvascular dysfunction (CMD), characterized by impaired regulation of blood flow in the coronary microcirculation, plays a key role in the pathogenesis of ischemic heart disease and is increasingly recognized as a contributor to…

Computational Engineering, Finance, and Science · Computer Science 2025-12-25 Haizhou Yang , Jiyang Zhang , Brahmajee K. Nallamothu , Krishna Garikipati , C. Alberto Figueroa

The use of cumulative incidence functions for characterizing the risk of one type of event in the presence of others has become increasingly popular over the past decade. The problems of modeling, estimation and inference have been treated…

Methodology · Statistics 2020-11-16 Youngjoo Cho , Annette M. Molinaro , Chen Hu , Robert L. Strawderman

The solution here proposed can be used to conduct economic analysis in randomized clinical trials. It is based on a statistical approach and aims at calculating a revised version of the incremental costeffective ratio (ICER) in order to…

Applications · Statistics 2013-06-19 C. D'Urso

To better understand mortality change with age capturing the variability in individuals' rates of aging, we performed comprehensive analysis of statistical properties of a cumulative index of age-associated disorders (deficits), called a…

Populations and Evolution · Quantitative Biology 2007-05-23 A. Kulminski , A. Yashin , I. Akushevich , S. Ukraintseva , K. Land , K. Arbeev , K. Manton

As standards of care advance, patients are living longer and once-fatal diseases are becoming manageable. Clinical trials increasingly focus on reducing disease burden, which can be quantified by the timing and occurrence of multiple…