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Lead optimization in drug discovery requires efficiently navigating vast chemical space through iterative cycles to enhance molecular properties while preserving structural similarity to the original lead compound. Despite recent advances,…

Machine Learning · Computer Science 2025-09-29 Ziqing Wang , Yibo Wen , William Pattie , Xiao Luo , Weimin Wu , Jerry Yao-Chieh Hu , Abhishek Pandey , Han Liu , Kaize Ding

Neural metrics for machine translation (MT) evaluation have become increasingly prominent due to their superior correlation with human judgments compared to traditional lexical metrics. Researchers have therefore utilized neural metrics…

Computation and Language · Computer Science 2025-11-21 Hippolyte Gisserot-Boukhlef , Ricardo Rei , Emmanuel Malherbe , Céline Hudelot , Pierre Colombo , Nuno M. Guerreiro

Model fusion combines multiple Large Language Models (LLMs) with different strengths into a more powerful, integrated model through lightweight training methods. Existing works on model fusion focus primarily on supervised fine-tuning…

Machine Learning · Computer Science 2026-05-26 Yanggan Gu , Yuanyi Wang , Zhaoyi Yan , Yiming Zhang , Qi Zhou , Fei Wu , Hongxia Yang

Generative recommendation has recently emerged as a promising paradigm for sequential recommendation. It formulates the task as an autoregressive generation process, predicting tokens of the next item conditioned on user interaction…

Information Retrieval · Computer Science 2026-05-29 Yuanqing Yu , Yifan Wang , Weizhi Ma , Zhiqiang Guo , Min Zhang

This study addresses the challenge of noise in training datasets for Direct Preference Optimization (DPO), a method for aligning Large Language Models (LLMs) with human preferences. We categorize noise into pointwise noise, which includes…

Machine Learning · Computer Science 2025-04-21 Junkang Wu , Yuexiang Xie , Zhengyi Yang , Jiancan Wu , Jiawei Chen , Jinyang Gao , Bolin Ding , Xiang Wang , Xiangnan He

Direct Preference Optimization (DPO) has emerged as a powerful approach to align text-to-image (T2I) models with human feedback. Unfortunately, successful application of DPO to T2I models requires a huge amount of resources to collect and…

Computer Vision and Pattern Recognition · Computer Science 2024-10-31 Shyamgopal Karthik , Huseyin Coskun , Zeynep Akata , Sergey Tulyakov , Jian Ren , Anil Kag

Direct Preference Optimization (DPO) has emerged as an important approach for learning from human preferences in aligning large language models (LLMs). However, collecting human preference data is costly and inefficient, motivating methods…

Computation and Language · Computer Science 2025-12-01 Jiacheng Guo , Zihao Li , Jiahao Qiu , Yue Wu , Mengdi Wang

Generative AI can now synthesize strikingly realistic images from text, yet output quality remains highly sensitive to how prompts are phrased. Direct Preference Optimization (DPO) offers a lightweight, off-policy alternative to RL for…

Computation and Language · Computer Science 2025-07-30 Anas Mohamed , Azal Ahmad Khan , Xinran Wang , Ahmad Faraz Khan , Shuwen Ge , Saman Bahzad Khan , Ayaan Ahmad , Ali Anwar

The emergence of Retrieval-augmented generation (RAG) has alleviated the issues of outdated and hallucinatory content in the generation of large language models (LLMs), yet it still reveals numerous limitations. When a general-purpose LLM…

Computation and Language · Computer Science 2024-12-20 Jiayi Wu , Hengyi Cai , Lingyong Yan , Hao Sun , Xiang Li , Shuaiqiang Wang , Dawei Yin , Ming Gao

Reinforcement learning (RL) has emerged as an effective approach for enhancing the reasoning capabilities of large language models (LLMs), especially in scenarios where supervised fine-tuning (SFT) falls short due to limited…

Machine Learning · Computer Science 2026-04-15 Jian Xiong , Jingbo Zhou , Jingyong Ye , Qiang Huang , Dejing Dou

Recent advancements in generative models, particularly large language models (LLMs) and diffusion models, have been driven by extensive pretraining on large datasets followed by post-training. However, current post-training methods such as…

Large language models (LLMs) have shown promising abilities as cost-effective and reference-free evaluators for assessing language generation quality. In particular, pairwise LLM evaluators, which compare two generated texts and determine…

Computation and Language · Computer Science 2024-10-15 Han Zhou , Xingchen Wan , Yinhong Liu , Nigel Collier , Ivan Vulić , Anna Korhonen

Recently, Large Language Models (LLMs) have rapidly evolved, approaching Artificial General Intelligence (AGI) while benefiting from large-scale reinforcement learning to enhance Human Alignment (HA) and Reasoning. Recent reward-based…

Machine Learning · Computer Science 2025-06-19 Xuerui Su , Shufang Xie , Guoqing Liu , Yingce Xia , Renqian Luo , Peiran Jin , Zhiming Ma , Yue Wang , Zun Wang , Yuting Liu

Automatic Prompt Optimization (APO) is a powerful approach for extracting performance from large language models without modifying their weights. Many existing methods rely on trial-and-error, testing different prompts or in-context…

Artificial Intelligence · Computer Science 2026-02-03 Mayank Singh , Vikas Yadav , Eduardo Blanco

Direct Preference Optimization is an offline post-SFT method for aligning language models from preference pairs, with strong results in instruction following and summarization. However, DPO's sequence-level implicit reward can be brittle…

Computation and Language · Computer Science 2026-03-03 Samah Fodeh , Linhai Ma , Ganesh Puthiaraju , Srivani Talakokkul , Afshan Khan , Ashley Hagaman , Sarah R. Lowe , Aimee Kendall Roundtree

Offline preference alignment for language models such as Direct Preference Optimization (DPO) is favored for its effectiveness and simplicity, eliminating the need for costly reinforcement learning. Various offline algorithms have been…

Machine Learning · Computer Science 2025-07-28 Junbo Li , Zhangyang Wang , Qiang Liu

Text-to-3D generation automates 3D content creation from textual descriptions, which offers transformative potential across various fields. However, existing methods often struggle to align generated content with human preferences, limiting…

Computation and Language · Computer Science 2025-02-10 Zhenglin Zhou , Xiaobo Xia , Fan Ma , Hehe Fan , Yi Yang , Tat-Seng Chua

We study the potential of large language models (LLMs) as proxies for humans to simplify preference elicitation (PE) in combinatorial assignment. While traditional PE methods rely on iterative queries to capture preferences, LLMs offer a…

Artificial Intelligence · Computer Science 2025-02-17 Ermis Soumalias , Yanchen Jiang , Kehang Zhu , Michael Curry , Sven Seuken , David C. Parkes

Direct Preference Optimization (DPO) is a widely used reinforcement learning from human feedback (RLHF) method across various domains. Recent research has increasingly focused on the role of token importance in improving DPO effectiveness.…

Computation and Language · Computer Science 2025-12-01 Jian Li , Shenglin Yin , Yujia Zhang , Alan Zhao , Xi Chen , Xiaohui Zhou , Pengfei Xu

Aligning Large Language Models (LLMs) with human feedback is crucial for their development. Existing preference optimization methods such as DPO and KTO, while improved based on Reinforcement Learning from Human Feedback (RLHF), are…

Computation and Language · Computer Science 2024-12-23 Shuo Xie , Fangzhi Zhu , Jiahui Wang , Lulu Wen , Wei Dai , Xiaowei Chen , Junxiong Zhu , Kai Zhou , Bo Zheng