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Constructing of molecular structural models from Cryo-Electron Microscopy (Cryo-EM) density volumes is the critical last step of structure determination by Cryo-EM technologies. Methods have evolved from manual construction by structural…

We present MIX'EM, a novel solution for unsupervised image classification. MIX'EM generates representations that by themselves are sufficient to drive a general-purpose clustering algorithm to deliver high-quality classification. This is…

Cryo-electron tomography (Cryo-ET) is a 3D imaging technique that enables the systemic study of shape, abundance, and distribution of macromolecular structures in single cells in near-atomic resolution. However, the systematic and efficient…

We consider the problem of recovering the three-dimensional atomic structure of a flexible macromolecule from a heterogeneous cryo-EM dataset. The dataset contains noisy tomographic projections of the electrostatic potential of the…

Cluster analysis faces two problems in high dimensions: first, the `curse of dimensionality' that can lead to overfitting and poor generalization performance; and second, the sheer time taken for conventional algorithms to process large…

Unsupervised classification called clustering is a process of organizing objects into groups whose members are similar in some way. Clustering of uncertain data objects is a challenge in spatial data bases. In this paper we use Probability…

We initiate the study of sparse recovery problems under the Earth-Mover Distance (EMD). Specifically, we design a distribution over m x n matrices A such that for any x, given Ax, we can recover a k-sparse approximation to x under the EMD…

Subspace clustering is the problem of clustering data that lie close to a union of linear subspaces. In the abstract form of the problem, where no noise or other corruptions are present, the data are assumed to lie in general position…

Clustering and estimating cluster means are core problems in statistics and machine learning, with k-means and Expectation Maximization (EM) being two widely used algorithms. In this work, we provide a theoretical explanation for the…

Datasets in high-dimension do not typically form clusters in their original space; the issue is worse when the number of points in the dataset is small. We propose a low-computation method to find statistically significant clustering…

Electron tomography (ET) has become a standard technique for 3D characterization of materials at the nano-scale. Traditional reconstruction algorithms such as weighted back projection suffer from disruptive artifacts with insufficient…

Spectral clustering is one of the most popular clustering methods. However, the high computational cost due to the involved eigen-decomposition procedure can immediately hinder its applications in large-scale tasks. In this paper we use…

Compressed Sensing suggests that the required number of samples for reconstructing a signal can be greatly reduced if it is sparse in a known discrete basis, yet many real-world signals are sparse in a continuous dictionary. One example is…

We outline a new approach for solving optimization problems which enforce triangle inequalities on output variables. We refer to this as metric-constrained optimization, and give several examples where problems of this form arise in machine…

The high dimensionality of hyperspectral images often results in the degradation of clustering performance. Due to the powerful ability of deep feature extraction and non-linear feature representation, the clustering algorithm based on deep…

We aim to improve segmentation through the use of machine learning tools during region agglomeration. We propose an active learning approach for performing hierarchical agglomerative segmentation from superpixels. Our method combines…

A simple, yet general, formalism for the optimized linear combination of astrophysical images is constructed and demonstrated. The formalism allows the user to combine multiple undersampled images to provide oversampled output at high…

Cryo-EM is a vital technique for determining 3D structure of biological molecules such as proteins and viruses. The cryo-EM reconstruction problem is challenging due to the high noise levels, the missing poses of particles, and the…

Clustering high-dimensional data is especially challenging when cluster distributions are heavy tailed and only approximately elliptical. Existing high-dimensional methods are largely built for Gaussian or other light-tailed models, whereas…

In this paper, we propose a regularized mixture probabilistic model to cluster matrix data and apply it to brain signals. The approach is able to capture the sparsity (low rank, small/zero values) of the original signals by introducing…