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Testing effect size homogeneity is an essential part when conducting a meta-analysis. Comparative studies of effect size homogeneity tests in case of binary outcomes are found in the literature, but no test has come out as an absolute…

Methodology · Statistics 2022-03-11 Osama Almalik

When evaluating the efficacy of social programs and medical treatments using randomized experiments, the estimated overall average causal effect alone is often of limited value and the researchers must investigate when the treatments do and…

Applications · Statistics 2013-05-27 Kosuke Imai , Marc Ratkovic

Estimating treatment effects conditional on observed covariates can improve the ability to tailor treatments to particular individuals. Doing so effectively requires dealing with potential confounding, and also enough data to adequately…

Extensions of linear models are very commonly used in the analysis of biological data. Whereas goodness of fit measures such as the coefficient of determination (R2) or the adjusted R2 are well established for linear models, it is not…

Methodology · Statistics 2018-05-04 Hans-Peter Piepho

Meta-analytic methods may be used to combine evidence from different sources of information. Quite commonly, the normal-normal hierarchical model (NNHM) including a random-effect to account for between-study heterogeneity is utilized for…

Methodology · Statistics 2020-02-25 Christian Röver , Tim Friede

A new meta-algorithm for estimating the conditional average treatment effects is proposed in the paper. The main idea underlying the algorithm is to consider a new dataset consisting of feature vectors produced by means of concatenation of…

Machine Learning · Statistics 2019-09-10 Lev V. Utkin , Mikhail V. Kots , Viacheslav S. Chukanov

Determining the strength of non-linear statistical dependencies between two variables is a crucial matter in many research fields. The established measure for quantifying such relations is the mutual information. However, estimating mutual…

Data Analysis, Statistics and Probability · Physics 2019-07-24 Damián G. Hernández , Inés Samengo

Evidence syntheses and meta-analyses are used to inform clinical practice guidelines and health economic evaluations. However, heterogeneity of treatment effects poses a significant challenge. Conventional meta-analysis addresses…

Meta-analysis is a powerful tool to synthesize findings from multiple studies. The normal-normal random-effects model is widely used to account for between-study heterogeneity. However, meta-analysis of sparse data, which may arise when the…

Methodology · Statistics 2024-06-10 Taojun Hu , Yi Zhou , Satoshi Hattori

Meta-analysis involves combining summary information for related but independent studies. It uses different relationship to combine position measure as well as dispersion measures. The objective of this study is to discuss a relationship…

Methodology · Statistics 2012-02-07 Jose Fausto de Morais

In meta-analysis with continuous outcomes, the use of effect sizes based on the means is the most common. It is often found, however, that only the quantile summary measures are reported in some studies, and in certain scenarios, a…

Methodology · Statistics 2024-11-19 Alysha M De Livera , Luke Prendergast , Udara Kumaranathunga

Many applications of causal inference require using treatment effects estimated on a study population to make decisions in a separate target population. We consider the challenging setting where there are covariates that are observed in the…

Machine Learning · Computer Science 2024-10-22 Khurram Yamin , Vibhhu Sharma , Ed Kennedy , Bryan Wilder

Having a sufficient quantity of quality data is a critical enabler of training effective machine learning models. Being able to effectively determine the adequacy of a dataset prior to training and evaluating a model's performance would be…

Machine Learning · Computer Science 2026-04-28 Arya Hatamian , Lionel Levine , Haniyeh Ehsani Oskouie , Majid Sarrafzadeh

Meta-analysis is a well-established tool used to combine data from several independent studies, each of which usually compares the effect of an experimental treatment with a control group. While meta-analyses are often performed using…

Methodology · Statistics 2025-06-02 Phuc Thien Tran , Long-Hao Xu , Christian Röver , Tim Friede

Mendelian randomization is a powerful tool for causal inference in observational studies. The two-sample summary-data design, which estimates genetic associations with exposures and outcomes in separate cohorts, is the most widely used…

Methodology · Statistics 2026-04-29 Dingke Tang , Xuming He , Shu Yang

Meta-analysis is commonly used to combine results from multiple clinical trials, but traditional meta-analysis methods do not refer explicitly to a population of individuals to whom the results apply and it is not clear how to use their…

Network meta-analysis is an evidence synthesis method for comparing the effectiveness of multiple available treatments. To justify evidence synthesis, consistency is an important assumption; however, existing methods founded on statistical…

Methodology · Statistics 2025-04-29 Kotaro Sasaki , Hisashi Noma

Effect size indices are useful tools in study design and reporting because they are unitless measures of association strength that do not depend on sample size. Existing effect size indices are developed for particular parametric models or…

Methodology · Statistics 2025-01-08 Simon Vandekar , Ran Tao , Jeffrey Blume

We consider the problem of meta-analyzing two-group studies that report the median of the outcome. Often, these studies are excluded from meta-analysis because there are no well-established statistical methods to pool the difference of…

Methodology · Statistics 2022-06-22 Sean McGrath , Hojoon Sohn , Russell Steele , Andrea Benedetti

Cochran's $Q$ statistic is routinely used for testing heterogeneity in meta-analysis. Its expected value (under an incorrect null distribution) is part of several popular estimators of the between-study variance, $\tau^2$. Those…

Methodology · Statistics 2023-04-11 Elena Kulinskaya , David C. Hoaglin
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