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Motivation: High throughput DNA sequencing (HTS) technologies generate an excessive number of small DNA segments -- called short reads -- that cause significant computational burden. To analyze the entire genome, each of the billions of…

Genomics · Quantitative Biology 2020-09-29 Mohammed Alser , Hasan Hassan , Hongyi Xin , Oğuz Ergin , Onur Mutlu , Can Alkan

In the past decade, we have witnessed a dramatically increasing volume of data collected from varied sources. The explosion of data has transformed the world as more information is available for collection and analysis than ever before. To…

Distributed, Parallel, and Cluster Computing · Computer Science 2022-01-04 Ying Mao , Yuqi Fu , Wenjia Zheng , Long Cheng , Qingzhi Liu , Dingwen Tao

Heart failure (HF) affects at least 26 million people worldwide, so predicting adverse events in HF patients represents a major target of clinical data science. However, achieving large sample sizes sometimes represents a challenge due to…

Cassandra is one of the most widely used distributed data stores these days. Cassandra supports flexible consistency guarantees over a wide-column data access model and provides almost linear scale-out performance. This enables application…

Distributed, Parallel, and Cluster Computing · Computer Science 2016-10-11 Roy Friedman , Roni Licher

Computing has a huge memory problem. The memory system, consisting of multiple technologies at different levels, is responsible for most of the energy consumption, performance bottlenecks, robustness problems, monetary cost, and hardware…

Hardware Architecture · Computer Science 2025-09-05 Onur Mutlu , Ataberk Olgun , Ismail Emir Yuksel

This paper investigates whether hybrid quantum-classical machine learning can deliver practical improvements in financial fraud detection performance for card-based and other payment transactions. Building on a Guided Quantum Compressor…

Quantum Physics · Physics 2026-05-05 Rodrigo Chaves , Kunal Kumar , Bruno Chagas , Rory Linerud , Brannen Sorem , Javier Mancilla , Bryn Bell

Edge computing has emerged as a pivotal technology, offering significant advantages such as low latency, enhanced data security, and reduced reliance on centralized cloud infrastructure. These benefits are crucial for applications requiring…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-24 Tomasz Szydlo , Viacheslav Horbanov , Devki Nandan Jha , Shashikant Ilager , Aleksander Slominski , Rajiv Ranjan

With the success of deep learning techniques in a broad range of application domains, many deep learning software frameworks have been developed and are being updated frequently to adapt to new hardware features and software libraries,…

Distributed, Parallel, and Cluster Computing · Computer Science 2017-11-10 Pengfei Xu , Shaohuai Shi , Xiaowen Chu

SQL queries, with the AND, OR, and NOT operators, constitute a broad class of highly used queries. Thus, their cardinality estimation is important for query optimization. In addition, a query planner requires the set-theoretic cardinality…

Databases · Computer Science 2020-04-16 Rojeh Hayek , Oded Shmueli

Edge computing addresses critical limitations of cloud computing such as high latency and network congestion by decentralizing processing from cloud to the edge. However, the need for software replication across heterogeneous edge devices…

Performance · Computer Science 2025-05-09 Ragini Gupta , Klara Nahrstedt

Modern cloud data warehouses store data in micro-partitions and rely on metadata (e.g., zonemaps) for efficient data pruning during query processing. Maintaining data clustering in a large-scale table is crucial for effective data pruning.…

Databases · Computer Science 2026-03-18 Yipeng Liu , Renfei Zhou , Jiaqi Yan , Huanchen Zhang

Hashing is at the heart of large-scale image similarity search, and recent methods have been substantially improved through deep learning techniques. Such algorithms typically learn continuous embeddings of the data. To avoid a subsequent…

Computer Vision and Pattern Recognition · Computer Science 2024-01-17 Lucas R. Schwengber , Lucas Resende , Paulo Orenstein , Roberto I. Oliveira

Metagenomics has led to significant advancements in many fields. Metagenomic analysis commonly involves the key tasks of determining the species present in a sample and their relative abundances. These tasks require searching large…

We present a detailed study of cardinality-aware top-$k$ classification, a novel approach that aims to learn an accurate top-$k$ set predictor while maintaining a low cardinality. We introduce a new target loss function tailored to this…

Machine Learning · Computer Science 2024-07-12 Corinna Cortes , Anqi Mao , Christopher Mohri , Mehryar Mohri , Yutao Zhong

Computing is bottlenecked by data. Large amounts of application data overwhelm storage capability, communication capability, and computation capability of the modern machines we design today. As a result, many key applications' performance,…

Hardware Architecture · Computer Science 2020-08-17 Onur Mutlu

Modern multi-tenant, hardware-heterogeneous computing environments pose significant challenges for effective workload orchestration. Simple heuristics for assessing workload performance, such as CPU utilization or application-level metrics,…

Distributed, Parallel, and Cluster Computing · Computer Science 2026-02-27 Oliver Larsson , Thijs Metsch , Cristian Klein , Erik Elmroth

Predicting future resource demand in Cloud Computing is essential for optimizing the trade-off between serving customers' requests efficiently and minimizing the provisioning cost. Modelling prediction uncertainty is also desirable to…

Distributed, Parallel, and Cluster Computing · Computer Science 2023-11-14 Andrea Rossi , Andrea Visentin , Diego Carraro , Steven Prestwich , Kenneth N. Brown

By supporting the access of multiple memory words at the same time, Bit-line Computing (BC) architectures allow the parallel execution of bit-wise operations in-memory. At the array periphery, arithmetic operations are then derived with…

Hardware Architecture · Computer Science 2022-09-14 Marco Rios , Flavio Ponzina , Alexandre Levisse , Giovanni Ansaloni , David Atienza

Modern applications process massive data volumes that overwhelm the storage and retrieval capabilities of memory systems, making memory the primary performance and energy-efficiency bottleneck of computing systems. Although many…

Hardware Architecture · Computer Science 2026-03-10 Rahul Bera

Graph partitioning plays a pivotal role in various distributed graph processing applications, including graph analytics, graph neural network training, and distributed graph databases. Graphs that require distributed settings are often too…

Databases · Computer Science 2024-12-11 Milad Rezaei Hajidehi , Sraavan Sridhar , Margo Seltzer